Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Emilija Zivkovic, Milos Diklic, Dragoslava Dikic, Milica Tosic, Bojana Beleslin-Cokic, Teodora Dragojevic, Mirjana Gotic, Juan F. Santibanez, Vladan Cokic
Summary: Chronic inflammation plays a crucial role in neoplastic disorders like myeloproliferative neoplasm, regulating angiogenesis. This study found that VEGF and IL-6 have different impacts on the expression of angiogenic factors in patients with MPN and HEL cells. VEGF was shown to regulate angiogenic factors in PMF while increasing their expression in PV through inflammation-related signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Anuradha S. Tripathy, Siddhesh Vishwakarma, Diptee Trimbake, Yogesh K. Gurav, Varsha A. Potdar, Nitin D. Mokashi, Sudhir D. Patsute, Himanshu Kaushal, Manohar L. Choudhary, Bipin N. Tilekar, Prakash Sarje, Varsha S. Dange, Priya Abraham
Summary: The study found that patients infected with SARS-CoV-2 have higher levels of inflammatory cytokines and lower levels of antiviral cytokines compared to uninfected individuals. All key analytes were significantly lower in recovered individuals than in patients, but the level of CXCL10 was significantly higher in recovered patients than in controls, suggesting that the immune system of SARS-CoV-2 patients may take a longer time to normalize.
ARCHIVES OF VIROLOGY
(2021)
Article
Plant Sciences
Isadora de Fatima Braga Magalhaes, Ana Leticia Marinho Figueiredo, Elizeu Mendes da Silva, Adryan Adam Batalha de Miranda, Claudia Quintino da Rocha, Katia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva
Summary: A study focuses on the anti-inflammatory potential of Passovia ovata extract, which contains high levels of flavonoids. The results demonstrate significant reduction in inflammatory markers both in cell experiments and animal models. This study indicates the potential of Passovia ovata extract as a new agent for suppressing inflammatory responses.
Article
Biochemistry & Molecular Biology
Stefan Bidula
Summary: G4s are non-canonical secondary structures in DNA and RNA that play roles in transcription and translation regulation. They are being studied as potential drug targets in cancer due to their ability to regulate gene expression and inhibit cancer cell growth. A computational analysis revealed high frequencies of G4-forming sequences in the promoters of various cytokines and chemokines, similar to those observed in proto-oncogenes. Additionally, many gene promoters contain sequences with high propensity to form G4s, mainly located in binding sites for transcription factors involved in inflammation and immunity.
Article
Biochemistry & Molecular Biology
Aakanksha Jha, Joseph Larkin III, Erika Moore
Summary: This study introduces a PEGDA hydrogel platform to investigate the utilization of SOCS1-KIR as a macrophage phenotype manipulating peptide. Results from immunocytochemistry, cytokine secretion assays, and gene expression analysis demonstrate a reduction in M1 activation due to SOCS1-KIR treatment. The retention of SOCS1-KIR in the hydrogel and the unaffected swelling ratio of the hydrogel are also demonstrated.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Camila M. L. Machado, Magdalena Skubal, Katja Haedicke, Fabio P. Silva, Evan P. Stater, Thais L. A. de O. Silva, Erico T. Costa, Cibele Masotti, Andreia H. Otake, Luciana N. S. Andrade, Mara de S. Junqueira, Hsiao-Ting Hsu, Sudeep Das, Benedict Mc Larney, Edwin C. Pratt, Yevgeniy Romin, Ning Fan, Katia Manova-Todorova, Martin Pomper, Jan Grimm
Summary: Cell membrane-derived particles (Mp) shed from tumor cells have the potential to be used as drug delivery vehicles for targeted and immunotherapeutic treatments. Prostate-specific membrane antigen (PSMA) is highly expressed in Mp and extracellular vesicles (EV) from prostate cancer. It has been discovered that PSMA can be transferred to the tumor microenvironment through Mp and alter cellular characteristics, resulting in increased secretion of angiogenic factors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Aikaterini Gatsiou, Kateryna Sopova, Alexandros Tselepis, Konstantinos Stellos
Summary: Platelets are immune cells known for their haemostatic properties and play a key role in vascular regeneration and angiogenesis by releasing growth factors. The IL-17A/IL-17RA axis selectively induces the release of pro-angiogenic factors from platelets, affecting endothelial cells and driving them towards a pro-angiogenic state.
Review
Biochemistry & Molecular Biology
Tinsley Claire Douglas, Sari S. Hannila
Summary: SLPI is a small but powerful member of the serine protease inhibitor family with both anti-protease and anti-inflammatory functions. It can inhibit the production of pro-inflammatory cytokines, prevent neutrophil infiltration, and regulate the activity of the transcription factor NF-KB.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Oncology
Xinyi Lou, Shixin Duan, Mengkai Li, Yao Yuan, Shiyi Chen, Zhiming Wang, Zishu Wang, Lei Sun, Feng Qian
Summary: IL-36 alpha activates NF-kappa B and MAPK signaling pathways in macrophages, leading to the expression of inflammatory factors. Additionally, IL-36 alpha has significant anti-tumor effects by altering the tumor microenvironment and promoting the infiltration of immune cells while decreasing suppressor cells and regulatory T cells.IL-36 alpha also synergizes with PD-L1 antibody to enhance its anti-tumor effect on melanoma. This study reveals a new role for IL-36 alpha in promoting anti-tumor immune responses and suggests its potential for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Robert A. Saxton, Naotaka Tsutsumi, Leon L. Su, Gita C. Abhiraman, Kritika Mohan, Lukas T. Henneberg, Nanda G. Aduri, Cornelius Gati, K. Christopher Garcia
Summary: By determining the structure of the IL-10 receptor complex and uncovering differences in IL-10 response thresholds across immune cell populations, this study provides a mechanistic blueprint for manipulating the pleiotropic actions of IL-10. Some IL-10 variants displayed myeloid-biased activity, suppressing macrophage activation without stimulating inflammatory CD8(+) T cells, thus uncoupling the major opposing functions of IL-10.
Article
Medicine, Research & Experimental
David Cabrerizo-Granados, Raul Pena, Laura Palacios, Laura Carrillo-Bosch, Josep Lloreta-Trull, Laura Comerma, Mar Iglesias, Antonio Garcia de Herreros
Summary: This study revealed a novel role for Snail1 in endothelial cell activation, demonstrating that these cells impact not only on angiogenesis, but also on tumor onset and phenotype. Specific depletion of Snail1 in endothelial cells in mice delayed the formation of mammary gland tumors and resulted in tumors with a papillary phenotype. Human breast papillary carcinomas also showed lower angiogenesis and staining of Snail1 compared to other breast neoplasms. High expression of Snail1 in human breast tumors was strongly correlated with high angiogenesis.
Review
Toxicology
Adelaide Sousa, Tracey D. Bradshaw, Daniela Ribeiro, Eduarda Fernandes, Marisa Freitas
Summary: Nanotechnology is a promising technology of the twenty-first century, with silver nanoparticles (AgNP) being the most widely commercialized nanosystems. However, concerns have been raised about the potential pro-inflammatory effects of AgNP on the intestinal system after human oral exposure.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiuhua Yang, Yingying Tian, Linlin Zheng, Thanh Luu, Joanne Kwak-Kim
Summary: Recurrent pregnancy losses (RPL) is a common reproductive disorder with various underlying etiologies. Recent research has shown that the immune response, particularly the imbalance of cytokines in the maternal-fetal interface, plays a crucial role in RPL. The increased NK1/NK2 ratio in decidual NK (dNK) cells of RPL patients contributes to a pro-inflammatory cytokine milieu and increased NK cell cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Multidisciplinary Sciences
Hamsa Thayele Purayil, Yehia Daaka
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Jude Masannat, Hamsa Thayele Purayil, Yushan Zhang, Michelle Russin, Iqbal Mahmud, Wanju Kim, Daiqing Liao, Yehia Daaka
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Yu Qin, Anindya Dey, Hamsa Thayele Purayil, Yehia Daaka
Article
Chemistry, Multidisciplinary
Thayele Purayil Hamsa, Punathil Thejass, Girija Kuttan
DRUG AND CHEMICAL TOXICOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Xiaojie Ma, Laura Espana-Serrano, Wan-ju Kim, Hamsa Thayele Purayil, Zhongzhen Nie, Yehia Daaka
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
H. T. Purayil, Y. Zhang, A. Dey, Z. Gersey, L. Espana-Serrano, Y. Daaka
Article
Integrative & Complementary Medicine
Thayele Purayil Hamsa, Girija Kuttan
Article
Biochemistry & Molecular Biology
Hamsa Thayele Purayil, Yushan Zhang, Joseph B. Black, Raad Gharaibeh, Yehia Daaka
Summary: This study identified beta Arrestin 1 (beta Arr1) as a regulator of androgen receptor (AR) function in castration-resistant prostate cancer (CRPC). Beta Arr1 forms a complex with AR and beta Catenin in the nucleus, enhancing AR transcriptional function in CRPC. Depletion of beta Arr1 attenuates PC cell and tumor growth, while restoring nuclear beta Arr1 expression restores these processes. Targeting beta Arr1-regulated AR transcriptional function may lead to the development of new drugs for lethal CRPC.
Article
Oncology
Archana Mukhopadhyay, Laura E. Hanold, Hamsa Thayele Purayil, Solomon A. Gisemba, Sanjeewa N. Senadheera, Jane V. Aldrich
CANCER BIOLOGY & THERAPY
(2017)
Article
Oncology
Yushan Zhang, Hamsa Thayele Purayil, Joseph B. Black, Francis Fetto, Lauren D. Lynch, Jude N. Masannat, Yehia Daaka