Article
Food Science & Technology
Ting Gu, Wei Yuan, Chen Li, Zhilong Chen, Yuting Wen, Qiyi Zheng, Qing Yang, Xingyao Xiong, Anwen Yuan
Summary: alpha-Solanine exhibits inhibitory effects on human choriocarcinoma cells, reducing colony formation, increasing cell apoptosis, and decreasing migration and invasion abilities. The mechanism may involve the downregulation of matrix metalloproteinases. Its suppressive effects were further confirmed in vivo, with smaller tumor volumes and promoted apoptosis in xenograft tumors.
Article
Biochemistry & Molecular Biology
Fateme Eidizade, Mohammad Soukhtanloo, Rahele Zhiani, Jamshid Mehrzad, Farshad Mirzavi
Summary: This research investigates the effects of urolithin-B on glioblastoma multiforme (GBM) U87 cells. The results suggest that urolithin-B can decrease cell viability, induce necrosis and cell cycle arrest, increase reactive oxygen species production, and reduce cell migration in U87 cells. These findings indicate that urolithin-B may be a promising compound for GBM treatment.
Article
Pharmacology & Pharmacy
Sanu K. Shaji, G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, Bipin G. Nair
Summary: Less-studied flavonoid Tamarixetin demonstrated significant dose-dependent inhibition of MMP-9 expression and cancer cell migration and invasion potential, indicating its potential as an anti-cancer agent. The compound also inhibits crucial functions necessary for MMP-9 activation and modulates endogenous regulators of MMP-9 activity, suggesting it could be a template for novel therapeutic applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Microbiology
Dorota Soltys-Kalina, Anna Grupa-Urbanska, Renata Lebecka, Maud Tallant, Isabelle Kellenberger, Brice Dupuis
Summary: This article explores the possibility of using glycoalkaloids (GAs) produced by potato tubers after the greening process as a control method for blackleg disease caused by Dickeya and Pectobacterium species. The study found that GAs extracted from four potato cultivars exhibited bacteriostatic and bactericidal effects against both bacteria strains in growth media. Field experiments showed that plants grown from green seed tubers had lower incidence of blackleg, except for one-year trial. However, the control effect was marginal, possibly due to low production of GAs by cv. Agria tubers after greening.
Article
Chemistry, Analytical
Xintong Lu, Luoyu Ding, Haohan Song, Wenxin Yu, Chaoqing Dong, Jicun Ren
Summary: A novel in situ single molecule spectroscopy method based on fluorescent correlation spectroscopy (FCS) technique was proposed for measuring MMP-9 activity in single living cells. The method utilizes a fluorescent specific peptide and a reference dye as dual probes, and ratiometric translational diffusion time as the measurement parameter.
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Bing Yu, Jinghua Pang, Jiawen You
Summary: Overexpression of miR-133a can reduce the invasion, proliferation, migration, and matrix metalloproteinase expression of NSCLC cells and promote cell apoptosis. This may be correlated to targeted down-regulation of LASP1 expression.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Kaushik Pal, Yuanchang Zhao, Yongliang Wang, Xuefeng Wang
Summary: This study demonstrated the recruitment of DNase in invadosomes, presenting a novel mechanism that is ubiquitous in various cell types and acts in synergy with proteases. The findings suggest a richer arsenal of degradative enzymes in invadosomes, providing evidence for a new immune and degradation mechanism.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Oncology
Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Han
Summary: The study found that the expression level of EMMPRIN in osteosarcoma is associated with metastasis-free survival, and EMMPRIN plays an important role in osteosarcoma metastasis by regulating the production of MMP and VEGF.
Article
Biochemistry & Molecular Biology
Matthew Thomas Ferreira, Juliano Andreoli Miyake, Renata Nascimento Gomes, Fabio Feitoza, Pollyana Bulgarelli Stevannato, Andrew Silva da Cunha, Fernanda de Oliveira Serachi, Alexandros Theodoros Panagopoulos, Alison Colquhoun
Summary: The study demonstrated the importance of PGE(2) signaling through the EP2 and EP4 receptors in controlling GBM cell biology, as well as a relationship between COX1 and MMP2 in these cells. These findings suggest a potential novel therapeutic target for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wen-Yueh Hung, Wei-Jiunn Lee, Guo-Zhou Cheng, Ching-Han Tsai, Yi-Chieh Yang, Tsung-Ching Lai, Ji-Qing Chen, Chi-Li Chung, Jer-Hwa Chang, Ming-Hsien Chien
Summary: Our study showed that penfluridol can reduce the migration, invasion, and adhesion of LADC cells, potentially by inhibiting MMP-12 expression and reversing MMP-12-induced EMT. MMP-12 may serve as a useful biomarker for predicting LADC progression and as a promising penfluridol target for treating metastatic LADC.
Article
Multidisciplinary Sciences
Ewa Mrowczynska, Ewa Mazurkiewicz, Antonina Joanna Mazur
Summary: This paper introduces a gelatin zymography assay for analyzing the gelatinase activity of melanoma cells, and describes the experimental procedure in detail. The method is simple, sensitive, and cost-effective, allowing for the detection of both active and inactive forms of metalloproteases.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Ji Young Kim, Tae-Min Cho, Jung Min Park, Soeun Park, Minsu Park, Kee Dal Nam, Dongmi Ko, Juyeon Seo, Seongjae Kim, Eunsun Jung, Lee Farrand, Cong-Truong Nguyen, Van-Hai Hoang, Minh Thanh La, Jihyae Ann, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Yoon-Jae Kim, Jae Hong Seo
Summary: SL-145 is a novel HSP90 inhibitor that induces apoptosis in TNBC cells by suppressing different oncogenic signaling pathways and does not trigger the heat shock response. It shows promising potential in inhibiting tumor growth and metastasis in animal models.
Article
Food Science & Technology
Xuehui Cui, Yitong Gong, Jun Ge, Xiaofei Feng, Xuemei Xiong, Zhen Shi, Qiusheng Zheng, Defang Li, Sixue Bi
Summary: Study found that a-solanine, a natural compound derived from potato, has anti-tumor and anti-inflammatory effects. The research revealed that a-solanine can induce ferroptosis in nasopharyngeal carcinoma cells by directly targeting HSP90a, inhibiting the expression of SLC7A11 and GPX4. The findings suggest the potential application of a-solanine in the treatment of nasopharyngeal carcinoma through ferroptosis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, Research & Experimental
Suwen Ou, Haipeng Chen, Hufei Wang, Jinhua Ye, Huidi Liu, Yangbao Tao, Songlin Ran, Xiaoqin Mu, Fangzhou Liu, Shuang Zhu, Kangjia Luo, Zilong Guan, Yinghu Jin, Rui Huang, Yanni Song, Shu-lin Liu
Summary: The study found that Fusobacterium nucleatum (F. nucleatum) can promote migration and metastasis of colorectal cancer (CRC) cells by upregulating Matrix metalloproteinase 7 (MMP7), and F. nucleatum and MMP7 may serve as potential therapeutic targets for suppressing CRC progression and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)