The Novel DA–CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APPSWE/PS1ΔE9 Mouse Model

DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

(2018) Yue Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease

(2018) Peng Feng et al.   NEUROPHARMACOLOGY

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

(2018) Christian Hölscher   NEUROPHARMACOLOGY

Enhanced Expression of the Voltage-Dependent Anion Channel 1 (VDAC1) in Alzheimer's Disease Transgenic Mice: An Insight into the Pathogenic Effects of Amyloid-β

(2018) Mar Cuadrado-Tejedor et al.   JOURNAL OF ALZHEIMERS DISEASE

Caspase-12 Activation is Involved in Amyloid-β Protein-Induced Synaptic Toxicity

(2018) Ricardo Quiroz-Baez et al.   JOURNAL OF ALZHEIMERS DISEASE

A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease

(2017) Ziyue Yuan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury

(2017) Ian A. Tamargo et al.   EXPERIMENTAL NEUROLOGY

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of BDNF in Alzheimer's disease

(2017) Heikki Tanila   NEUROBIOLOGY OF DISEASE

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?

(2017) Raymond T. Bartus et al.   NEUROBIOLOGY OF DISEASE

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?

(2017) Raymond T. Bartus et al.   NEUROBIOLOGY OF DISEASE

A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease

(2017) Jaishree Jalewa et al.   NEUROPHARMACOLOGY

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells

(2017) Theodora Panagaki et al.   Scientific Reports

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

(2016) Yu Cai et al.   Autophagy

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

(2016) Chenhui Ji et al.   BRAIN RESEARCH

Endoplasmic Reticulum Stress Induces the Early Appearance of Pro-apoptotic and Anti-apoptotic Proteins in Neurons of Five Familial Alzheimer′s Disease Mice

(2016) Xiao-Chun Chen et al.   CHINESE MEDICAL JOURNAL

Tolerable Levels of Nonclinical Vehicles and Formulations Used in Studies by Multiple Routes in Multiple Species With Notes on Methods to Improve Utility

(2016) Shayne Cox Gad et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

(2016) Jaishree Jalewa et al.   JOURNAL OF NEUROCHEMISTRY

A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

(2016) Lijun Cao et al.   NEUROREPORT

Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4

(2016) Grazyna Lietzau et al.   Oncotarget

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

(2015) Paula L. McClean et al.   BEHAVIOURAL BRAIN RESEARCH

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking

(2014) Elisabet Barbero-Camps et al.   AMERICAN JOURNAL OF PATHOLOGY

Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation

(2014) Wafa B'chir et al.   CELLULAR SIGNALLING

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

(2014) Paula L. McClean et al.   NEUROPHARMACOLOGY

The Evolving Biology of Microglia in Alzheimer’s Disease

(2014) Tarja M. Malm et al.   Neurotherapeutics

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model

(2013) Sherry A. Ferguson et al.   BEHAVIOURAL BRAIN RESEARCH

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

(2013) Mohit K. Sharma et al.   JOURNAL OF NEUROCHEMISTRY

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation

(2013) Diana A.T. Nijholt et al.   NEUROBIOLOGY OF AGING

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model

(2013) Emilie Faivre et al.   Alzheimers Research & Therapy

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

(2013) Lauren D Stutzbach et al.   Acta Neuropathologica Communications

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice

(2012) J H Ledo et al.   MOLECULAR PSYCHIATRY

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease

(2012) Jeroen J.M. Hoozemans et al.   Neurodegenerative Diseases

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

(2012) A.M. Duffy et al.   NEUROSCIENCE

Incretin therapy and its effect on body weight in patients with diabetes

(2012) Marcus Lind   Primary Care Diabetes

Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

(2011) Emilie Faivre et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells

(2011) Gordon P. Meares et al.   EXPERIMENTAL CELL RESEARCH

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2  Phosphorylation Pathway

(2011) Z. Mounir et al.   Science Signaling

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Current therapeutic targets for the treatment of Alzheimer’s disease

(2010) Joshua D Grill et al.   Expert Review of Neurotherapeutics

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

(2010) Simon Gengler et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice

(2010) Latha Devi et al.   PLoS One

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimers Disease

(2009) Lingfei Ruan et al.   Current Alzheimer Research

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON