标题
Current therapeutic targets for the treatment of Alzheimer’s disease
作者
关键词
-
出版物
Expert Review of Neurotherapeutics
Volume 10, Issue 5, Pages 711-728
出版商
Informa UK Limited
发表日期
2010-04-26
DOI
10.1586/ern.10.29
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The ADCS valproate neuroprotection trial: Primary efficacy and safety results
- (2009) Pierre N. Tariot et al. Alzheimers & Dementia
- Effects of rosiglitazone as monotherapy in APOE4-stratified subjects with mild-to-moderate Alzheimer's disease
- (2009) Michael Gold et al. Alzheimers & Dementia
- Drug development for Alzheimer's disease: Where are we now and where are we headed?
- (2009) Marwan N. Sabbagh American Journal Geriatric Pharmacotherapy
- Autoantibodies against β-amyloid are common in Alzheimer's disease and help control plaque burden
- (2009) Alexander Kellner et al. ANNALS OF NEUROLOGY
- A γ-secretase inhibitor decreases amyloid-β production in the central nervous system
- (2009) Randall J. Bateman et al. ANNALS OF NEUROLOGY
- Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening
- (2009) Alex Crowe et al. BIOCHEMISTRY
- Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E
- (2009) Jianjia Fan et al. BIOFACTORS
- SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist
- (2009) Simon N. Haydar et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition
- (2009) M. S. J. Elliott et al. BRAIN
- Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects
- (2009) Alain Patat et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice
- (2009) AD Medhurst et al. BRITISH JOURNAL OF PHARMACOLOGY
- Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders
- (2009) Bruno Vellas et al. Current Alzheimer Research
- Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise
- (2009) Antonello Mai et al. CURRENT PHARMACEUTICAL DESIGN
- Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial
- (2009) Robert C. Green JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Can Lithium or Valproate Untie Tangles in Alzheimer's Disease?
- (2009) Pierre N. Tariot et al. JOURNAL OF CLINICAL PSYCHIATRY
- Lithium Trial in Alzheimer's Disease
- (2009) Harald Hampel et al. JOURNAL OF CLINICAL PSYCHIATRY
- The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal
- (2009) John Hardy JOURNAL OF NEUROCHEMISTRY
- Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
- (2009) O L Lopez et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Amyloid Reduction by Amyloid- Vaccination Also Reduces Mouse Tau Pathology and Protects from Neuron Loss in Two Mouse Models of Alzheimer's Disease
- (2009) D. M. Wilcock et al. JOURNAL OF NEUROSCIENCE
- Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice
- (2009) W. J. Meilandt et al. JOURNAL OF NEUROSCIENCE
- Role of Amyloid- Glycine 33 in Oligomerization, Toxicity, and Neuronal Plasticity
- (2009) A. Harmeier et al. JOURNAL OF NEUROSCIENCE
- Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid- Load in an Alzheimer's Disease Mouse Model
- (2009) D. Puzzo et al. JOURNAL OF NEUROSCIENCE
- -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin
- (2009) Q.-L. Ma et al. JOURNAL OF NEUROSCIENCE
- Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice
- (2009) P. Yan et al. JOURNAL OF NEUROSCIENCE
- What we have learned from the myriad trials
- (2009) S. B. Hendrix et al. Journal of Nutrition Health & Aging
- Challenges in the conduct of disease-modifying trials in ad: Practical experience from a phase 2 trial of TAU-aggregation inhibitor therapy
- (2009) C. Wischik et al. Journal of Nutrition Health & Aging
- Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies
- (2009) Rocio G Urdinguio et al. LANCET NEUROLOGY
- HDAC2 negatively regulates memory formation and synaptic plasticity
- (2009) Ji-Song Guan et al. NATURE
- The curious case of clioquinol
- (2009) Lauren Cahoon NATURE MEDICINE
- Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
- (2009) Alan H Nagahara et al. NATURE MEDICINE
- Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
- (2009) Jessica B.S. Langbaum et al. NEUROIMAGE
- Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
- (2009) Samuel T Henderson et al. Nutrition & Metabolism
- Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening
- (2009) Christelle Cabrol et al. PLoS One
- Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory
- (2009) M. Xia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fibrillar amyloid- burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
- (2009) E. M. Reiman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel therapeutic strategies for neurodegenerative disease
- (2009) Hitoshi TANIMUKAI et al. Psychogeriatrics
- Avoiding Unintended Toxicity
- (2009) T. E. Golde et al. SCIENCE
- Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease
- (2008) Alireza Atri et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- The Atorvastatin/Donepezil in Alzheimer’s Disease Study (LEADe): Design and baseline characteristics
- (2008) Roy W. Jones et al. Alzheimers & Dementia
- Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab
- (2008) Maria del Pilar Martin ARCHIVES OF NEUROLOGY
- Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease
- (2008) Adam S. Fleisher et al. ARCHIVES OF NEUROLOGY
- Therapeutic potential of resveratrol in Alzheimer's disease
- (2008) Valérie Vingtdeux et al. BMC NEUROSCIENCE
- Hypometabolism as a therapeutic target in Alzheimer's disease
- (2008) Lauren C Costantini et al. BMC NEUROSCIENCE
- The histamine H3receptor: an attractive target for the treatment of cognitive disorders
- (2008) T A Esbenshade et al. BRITISH JOURNAL OF PHARMACOLOGY
- Neurotrophic Factors in Neurodegenerative Disorders
- (2008) Fabio Fumagalli et al. CNS DRUGS
- Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease
- (2008) Natalia Nalivaeva et al. Current Alzheimer Research
- Therapeutic Potential of γ -Secretase Inhibitors and Modulators
- (2008) Bruno Imbimbo CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons
- (2008) Kathie M. Bishop et al. EXPERIMENTAL NEUROLOGY
- Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
- (2008) Alan H. Nagahara et al. EXPERIMENTAL NEUROLOGY
- The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1
- (2008) Ying Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity
- (2008) Kenjiro Ono et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Notch: from neural development to neurological disorders
- (2008) Justin D. Lathia et al. JOURNAL OF NEUROCHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
- (2008) K. N. Green et al. JOURNAL OF NEUROSCIENCE
- Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3 Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing
- (2008) Y. Wen et al. JOURNAL OF NEUROSCIENCE
- A Two-Year Study with Fibrillar -Amyloid (A ) Immunization in Aged Canines: Effects on Cognitive Function and Brain A
- (2008) E. Head et al. JOURNAL OF NEUROSCIENCE
- Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease
- (2008) J. Wang et al. JOURNAL OF NEUROSCIENCE
- Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-A Antibody Administration in PDAPP Mice
- (2008) J. Koenigsknecht-Talboo et al. JOURNAL OF NEUROSCIENCE
- A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease
- (2008) Y. Matsuoka et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Will anti-amyloid therapies work for Alzheimer's disease?
- (2008) Peter H St George-Hyslop et al. LANCET
- Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
- (2008) Clive Holmes et al. LANCET
- Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
- (2008) Rachelle S Doody et al. LANCET
- Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
- (2008) Lars Lannfelt et al. LANCET NEUROLOGY
- Substrate-targeting γ-secretase modulators
- (2008) Thomas L. Kukar et al. NATURE
- Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
- (2008) Ganesh M Shankar et al. NATURE MEDICINE
- 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
- (2008) Norman R. Relkin et al. NEUROBIOLOGY OF AGING
- Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
- (2008) Z. Arvanitakis et al. NEUROLOGY
- Selective 5-HT6 Receptor Blockade Improves Spatial Recognition Memory and Reverses Age-Related Deficits in Spatial Recognition Memory in the Mouse
- (2008) Virginie Da Silva Costa et al. NEUROPSYCHOPHARMACOLOGY
- 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease
- (2008) Neil Upton et al. Neurotherapeutics
- Tau-based treatment strategies in neurodegenerative diseases
- (2008) Anja Schneider et al. Neurotherapeutics
- β-Secretase as a therapeutic target for Alzheimer’s disease
- (2008) Arun K. Ghosh et al. Neurotherapeutics
- Therapeutics for Alzheimer’s disease based on the metal hypothesis
- (2008) Ashley I. Bush et al. Neurotherapeutics
- Inhibition and modulation of γ-secretase for Alzheimer’s disease
- (2008) Michael S. Wolfe Neurotherapeutics
- Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice
- (2008) A. Marighetto et al. PSYCHOPHARMACOLOGY
- A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory
- (2008) M KING et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Chronic disease long-term drug prevention trials: Lessons from the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT)
- (2007) Curtis L. Meinert et al. Alzheimers & Dementia
- Reduced 5-HT2A receptor binding in patients with mild cognitive impairment
- (2007) S.G. Hasselbalch et al. NEUROBIOLOGY OF AGING
- Muscarinic acetylcholine receptors as CNS drug targets
- (2007) Christopher J. Langmead et al. PHARMACOLOGY & THERAPEUTICS
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