Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

(2016) Chenhui Ji et al.   BRAIN RESEARCH

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

(2016) Yanwei Li et al.   NEUROPHARMACOLOGY

A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

(2016) Lijun Cao et al.   NEUROREPORT

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

ATG12–ATG3 connects basal autophagy and late endosome function

(2015) Lyndsay Murrow et al.   Autophagy

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

(2015) Emma Robinson et al.   BASIC RESEARCH IN CARDIOLOGY

Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson’s disease mouse model

(2015) YanFang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

(2015) WeiZhen Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondria: A Therapeutic Target for Parkinson’s Disease?

(2015) Yu Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucagon-like peptide 1 protects INS-1E mitochondria against palmitate-mediated beta-cell dysfunction: a proteomic study

(2015) Federica Ciregia et al.   Molecular BioSystems

Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2015) W. Liu et al.   NEUROSCIENCE

Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells

(2015) Min Joo Kim et al.   Islets

Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease

(2015) Iciar Aviles-Olmos et al.   Journal of Parkinsons Disease

GLP-1-related proteins attenuate the effects of mitochondrial membrane damage in pancreatic β cells

(2014) Makiko Ogata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GLP-1 Analogue Liraglutide Protects Cardiomyocytes from High Glucose-induced Apoptosis by Activating the Epac-1/Akt Pathway

(2014) X.-M. Wu et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Exendin-4 protects adipose-derived mesenchymal stem cells from apoptosis induced by hydrogen peroxide through the PI3K/Akt–Sfrp2 pathways

(2014) Hao Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications

(2014) Bikash Manandhar et al.   JOURNAL OF MEDICINAL CHEMISTRY

New drug treatments show neuroprotective effects in Alzheimer′s and Parkinson′s diseases

(2014) Christian Hölscher   Neural Regeneration Research

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?

(2014) Fares Bassil et al.   PROGRESS IN NEUROBIOLOGY

Glucagon-Like Peptide-1: Glucose Homeostasis and Beyond

(2013) Young Min Cho et al.   Annual Review of Physiology

A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores

(2013) Christine M.A. Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

(2013) Christian Hölscher   JOURNAL OF ENDOCRINOLOGY

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

(2013) Mohit K. Sharma et al.   JOURNAL OF NEUROCHEMISTRY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2

(2013) J H Kim et al.   Cell Death & Disease

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Parkinson's disease, insulin resistance and novel agents of neuroprotection

(2012) Iciar Aviles-Olmos et al.   BRAIN

Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

(2012) Isidro Salcedo et al.   BRITISH JOURNAL OF PHARMACOLOGY

(Val8)GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice

(2012) Rachael Lennox et al.   ChemMedChem

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

(2012) Christian Hölscher   CNS DRUGS

Cellular models to investigate biochemical pathways in Parkinson’s disease

(2012) Tiziana Alberio et al.   FEBS Journal

Unraveling oxyntomodulin, GLP1's enigmatic brother

(2012) Alessandro Pocai   JOURNAL OF ENDOCRINOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy

(2011) Shvetank Sharma et al.   PLoS One

Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

(2010) R. Fan et al.   DIABETES OBESITY & METABOLISM

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

(2009) Sehee Kim et al.   JOURNAL OF ENDOCRINOLOGY

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of autophagy in Parkinson's disease

(2009) Zelda H Cheung et al.   Molecular Brain

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease

(2008) Alexander Harkavyi et al.   Journal of Neuroinflammation

Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo

(2008) B.H. Meurers et al.   NEUROBIOLOGY OF DISEASE

Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease

(2007) Göran Bertilsson et al.   JOURNAL OF NEUROSCIENCE RESEARCH