Article
Chemistry, Multidisciplinary
Nirmalya Pradhan, Nasim Akhtar, Barnali Nath, Jorge Pena-Garcia, Anjali Gupta, Horacio Perez-Sanchez, Sachin Kumar, Debasis Manna
Summary: Quinine derivatives effectively inhibit the activity of IDO1 by competing with heme, providing a potential avenue for immunotherapy-based drug discovery strategies.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oncology
Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang
Summary: IDO1, a heme-containing enzyme, plays a crucial role in the kynurenine pathway of tryptophan metabolism, with implications in immunity and neuronal function. Despite potential applications in cancer and neurodegenerative diseases, cautionary notes from clinical trials indicate a need for better understanding of IDO1 inhibition mechanisms.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Rui Qin, Chen Zhao, Chen-Ji Wang, Wei Xu, Jian-Yuan Zhao, Yan Lin, Yi-Yuan Yuan, Peng-Cheng Lin, Yao Li, Shimin Zhao, Yan Huang
Summary: This study demonstrated that IDO inhibitors activate CD8(+) T cells by increasing tryptophan levels and consequently downregulating PD-1 expression. Tryptophan and IDO inhibitors both potentiate CD8(+) T cells to induce apoptosis of cancer cells through different mechanisms, suggesting a potential synergistic effect in anticancer treatments.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Georgia Wells, Paul T. Kennedy, Lekh N. Dahal
Summary: Studies suggest that IDO expression in AML is associated with poor prognosis and correlates positively with Treg induction. Pharmacological inhibition of IDO may hold promise for the treatment of AML.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xinyu Qu, Yumeng Wang, Qian Jiang, Tingting Ren, Chenyan Guo, Keqin Hua, Junjun Qiu
Summary: This study investigates the mechanism of cervical cancer immune remodeling and explores the potential therapeutic targets. The research suggests that a combination treatment targeting IDO1 and ICB agent could improve the therapeutic efficacy of current cervical cancer immunotherapies.
CANCER COMMUNICATIONS
(2023)
Article
Cell Biology
Raghavan Chinnadurai, Amanda Paige Porter, Mihir Patel, Ariel Joy Lipat, Mathews H. Forsberg, Devi Rajan, Peiman Hematti, Christian M. Capitini, Charles Bruker
Summary: B7 family proteins and tryptophan degrading enzymes play crucial roles in tumor immune evasion. The interactions between tumor cells, stromal cells, and immune cells contribute to the development of an immunosuppressive tumor microenvironment. IFN-γ activated MSCs exhibit superior protection of HepG2 cells from PBMC mediated lysis and blockade of IFN-γ driven IDO activity in MSCs could be a potential immunotherapeutic strategy for hepatocellular carcinoma regression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Ferdaus Mohd Altaf Hossain, Seong Ok Park, Hyo Jin Kim, Jun Cheol Eo, Jin Young Choi, Maryum Tanveer, Erdenebelig Uyangaa, Koanhoi Kim, Seong Kug Eo
Summary: IDO plays a crucial role in preventing neutrophilic inflammation during asthma exacerbations caused by hRV infections, helping to regulate Th17 and Th1-type neutrophilic inflammation in the airway.
Review
Biochemistry & Molecular Biology
Leila Sawada, Antonio Carlos Rosario Vallinoto, Igor Brasil-Costa
Summary: EBV is an oncovirus associated with various types of cancer, with the reason for cancer development in only some infected individuals still unknown. EBV-associated cancers are more aggressive and resistant to treatment compared to EBV-negative cancers, making monoclonal antibodies targeting immune checkpoints a potential therapy.
Article
Biochemistry & Molecular Biology
Ilona Sadok, Kamila Rachwal, Ilona Jonik, Magdalena Staniszewska
Summary: A new HPLC-DAD method for determining IDO1 activity in human cancer cells has been developed and successfully validated, demonstrating its applicability in different cancer cell types. This approach provides a useful model for studying the role of the kynurenine pathway in cancer biology.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Rahul Singh, Deepak B. Salunke
Summary: IDO1 enzyme catalyzes the initial step of kynurenine pathway and is implicated in immune modulation, antioxidation, and cancer progression. Overexpression of IDO1 plays a pivotal role in immune evasion and cancer development. Research and development of IDO1 inhibitors holds significant potential in immunotherapy and disease treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Ana Dolsak, Stanislav Gobec, Matej Sova
Summary: This review discusses the key step of tryptophan metabolism and the importance of relevant enzymes in pathological conditions. In recent years, many inhibitors targeting these enzymes have been developed, and these inhibitors have entered clinical trials.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Engineering, Biomedical
Yixuan Guo, Yu Liu, Wei Wu, Daishun Ling, Qiao Zhang, Peng Zhao, Xi Hu
Summary: This article will discuss different types of IDO inhibitors and relevant clinical trials, especially feasible combined therapeutic modalities. In addition, it will also review cutting-edge nanomedicines that combine IDO inhibitors with other therapeutic modalities to effectively enhance the effectiveness of cancer therapy. Finally, the prospects of IDO inhibitors in clinical application and potential breakthroughs will be briefly discussed.
Letter
Immunology
Malene Hove-Skovsgaard, Julie Hogh, Michael Huy Cuong Pham, Andreas Dehlbaek Knudsen, Jan Gerstoft, Sisse Rye Ostrowski, Lars Kober, Thomas Benfield, Klaus Fuglsang Kofoed, Susanne Dam Nielsen
Summary: In this study, the association between peripheral T-cell activation, Th17 cells, T-regulatory cells (Tregs), and aortic aneurysm or aortic diameter in HIV-infected individuals was investigated. Computed tomography scans and flow cytometry were used to examine the aorta and T-cells in 428 participants, and 32 participants were found to have aortic aneurysm. None of the T-cell subsets were associated with aortic aneurysm, but activated T-cells and Tregs had opposite associations with aortic diameter, indicating an inverse impact.
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: The study showed that IDO plays a crucial role in cellular senescence during anoxia and reoxygenation, affecting the GCN2K and AhR pathways. Cellular senescence influences the outcome of AKI, highlighting the importance of investigating the role of IDO in cellular senescence and the potential therapeutic effects of IDO inhibitors.
Article
Multidisciplinary Sciences
Zhiren Wang, Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Leyla Estrella Cordova, Jinha Chung, Minhyeok Kim, Georg Wondrak, Jennifer Erdrich, Jianqin Lu
Summary: This study reported an EPA nanovesicle therapeutic platform called Epacasome, which showed improved pharmacokinetics and anti-tumor activity when combined with a PD-1 inhibitor in melanoma preclinical models.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Slim Fourati, Razvan Cristescu, Andrey Loboda, Aarthi Talla, Ali Filali, Radha Railkar, Andrea K. Schaeffer, David Favre, Dominic Gagnon, Yoav Peretz, I-Ming Wang, Chan R. Beals, Danilo R. Casimiro, Leonidas N. Carayannopoulos, Rafick-Pierre Sekaly
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Elizabeth Scheid, Pierre Major, Alain Bergeron, Olivera J. Finn, Russell D. Salter, Robin Eady, Bader Yassine-Diab, David Favre, Yoav Peretz, Claire Landry, Sebastien Hotte, Som D. Mukherjee, Gregory A. Dekaban, Corby Fink, Paula J. Foster, Jeffery Gaudet, Jean Gariepy, Rafick-Pierre Sekaly, Louis Lacombe, Yves Fradet, Ronan Foley
CANCER IMMUNOLOGY RESEARCH
(2016)
Review
Neurosciences
Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L. Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A. Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I. Israel, Shunsuke Kimura, Robert B. Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A. Skeberdis, Ian F. Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Hematology
P'ng Loke, David Favre, Peter W. Hunt, Jacqueline M. Leung, Bittoo Kanwar, Jeffrey N. Martin, Steven G. Deeks, Joseph M. McCune
Article
Hematology
David Favre, Cheryl A. Stoddart, Brinda Emu, Rebecca Hoh, Jeffrey N. Martin, Frederick M. Hecht, Steven G. Deeks, Joseph M. McCune
Article
Immunology
Nathalie Landry, Stephane Pillet, David Favre, Jean-Francois Poulin, Sonia Trepanier, Bader Yassine-Diab, Brian J. Ward
CLINICAL IMMUNOLOGY
(2014)
Meeting Abstract
Cell & Tissue Engineering
E. Scheid, A. Bergeron, G. A. Dekaban, D. Favre, R. Eady, P. O'Hoski, P. Major, R. Foley
Article
Cell Biology
David Favre, Jeff Mold, Peter W. Hunt, Bittoo Kanwar, P'ng Loke, Lillian Seu, Jason D. Barbour, Margaret M. Lowe, Anura Jayawardene, Francesca Aweeka, Yong Huang, Daniel C. Douek, Jason M. Brenchley, Jeffrey N. Martin, Frederick M. Hecht, Steven G. Deeks, Joseph M. McCune
SCIENCE TRANSLATIONAL MEDICINE
(2010)
Article
Chemistry, Medicinal
Wieslaw M. Kazmierski, Bing Xia, John Miller, Martha De la Rosa, David Favre, Richard M. Dunham, Yoshiaki Washio, Zhengrong Zhu, Feng Wang, Makda Mebrahtu, Hongfeng Deng, Jonathan Basilla, Liping Wang, Ghotas Evindar, Lijun Fan, Alison Olszewski, Ninad Prabhu, Christopher Davie, Jeffrey A. Messer, Vicente Samano
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Christopher C. Nixon, Maud Mavigner, Gavin C. Sampey, Alyssa D. Brooks, Rae Ann Spagnuolo, David M. Irlbeck, Cameron Mattingly, Phong T. Ho, Nils Schoof, Corinne G. Cammon, Greg K. Tharp, Matthew Kanke, Zhang Wang, Rachel A. Cleary, Amit A. Upadhyay, Chandrav De, Saintedym R. Wills, Shane D. Falcinelli, Cristin Galardi, Hasse Walum, Nathaniel J. Schramm, Jennifer Deutsch, Jeffrey D. Lifson, Christine M. Fennessey, Brandon F. Keele, Sherrie Jean, Sean Maguire, Baolin Liao, Edward P. Browne, Robert G. Ferris, Jessica H. Brehm, David Favre, Thomas H. Vanderford, Steven E. Bosinger, Corbin D. Jones, Jean-Pierre Routy, Nancie M. Archin, David M. Margolis, Angela Wahl, Richard M. Dunham, Guido Silvestri, Ann Chahroudi, J. Victor Garcia
Article
Biochemistry & Molecular Biology
Justin Harper, Shari Gordon, Chi Ngai Chan, Hong Wang, Emily Lindemuth, Cristin Galardi, Shane D. Falcinelli, Samuel L. M. Raines, Jenna L. Read, Kevin Nguyen, Colleen S. McGary, Michael Nekorchuk, Kathleen Busman-Sahay, James Schawalder, Colin King, Maria Pino, Luca Micci, Barbara Cervasi, Sherrie Jean, Andrew Sanderson, Brian Johns, A. Alicia Koblansky, Heather Amrine-Madsen, Jeffrey Lifson, David M. Margolis, Guido Silvestri, Katharine J. Bar, David Favre, Jacob D. Estes, Mirko Paiardini
Article
Biochemistry & Molecular Biology
Rodrigo F. Ortiz-Meoz, Liping Wang, Rosalie Matico, Anna Rutkowska-Klute, Martha De la Rosa, Sabrina Bedard, Robert Midgett, Katrin Strohmer, Douglas Thomson, Cunyu Zhang, Makda Mebrahtu, Jeffrey Guss, Rachel Totoritis, Thomas Consler, Nino Campobasso, David Taylor, Tia Lewis, Kurt Weaver, Marcel Muelbaier, John Seal, Richard Dunham, Wieslaw Kazmierski, David Favre, Giovanna Bergamini, Lisa Shewchuk, Alan Rendina, Guofeng Zhang
Summary: IDO1 is an immunoregulatory enzyme of interest for its potential therapeutic implications in cancer treatment. IDO1 inhibitors can act by competing with heme for binding or by coordinating their binding with the iron atom of IDO1 heme cofactor. Each mechanism may offer unique advantages in terms of specificity and duration of inhibition.
Meeting Abstract
Immunology
A. Okoye, R. Fromentin, J. Brehm, A. Maxwell, M. Vaidya, M. Pardons, V. Tai, J. Tang, J. Smedly, M. Axthelm, J. Lifson, L. Picker, L. Trautmann, D. Favre, N. Chomont
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2018)
Article
Immunology
Nicolas Chomont, Afam A. Okoye, David Favre, Lydie Trautmann
Correction
Hematology
P. Loke, D. Favre, P. W. Hunt