Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA

The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation

(2014) Xin Hong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Aurora-A Inhibition Offers a Novel Therapy Effective against Intracranial Glioblastoma

(2014) J. R. Van Brocklyn et al.   CANCER RESEARCH

Aurora Kinases as Targets in Drug-Resistant Neuroblastoma Cells

(2014) Martin Michaelis et al.   PLoS One

AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy

(2014) Ali Zekri et al.   TUMOR BIOLOGY

Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia

(2012) Mike Dennis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Inhibiting the Aurora B Kinase Potently Suppresses Repopulation During Fractionated Irradiation of Human Lung Cancer Cell Lines

(2012) Ali Sak et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors

(2012) Gary K. Schwartz et al.   INVESTIGATIONAL NEW DRUGS

Aurora kinase B/C inhibition impairs malignant glioma growth in vivo

(2012) Roberto Jose Diaz et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells

(2011) Kleiton Silva Borges et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

System-Level Analysis of Neuroblastoma Tumor-Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma

(2010) O. Morozova et al.   CLINICAL CANCER RESEARCH

Advances in the Treatment of Malignant Gliomas

(2010) Mustafa Khasraw et al.   Current Oncology Reports

Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography

(2009) Dick Pluim et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma

(2009) Arihiro Aihara et al.   JOURNAL OF HEPATOLOGY

Identification of genes that confer tumor cell resistance to the Aurora B kinase inhibitor, AZD1152

(2009) J Guo et al.   PHARMACOGENOMICS JOURNAL

Molecular Basis of Drug Resistance in Aurora Kinases

(2008) Fiona Girdler et al.   CHEMISTRY & BIOLOGY

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

(2008) E. Walsby et al.   HAEMATOLOGICA

The impact of p53 and p73 on aneuploidy and cancer

(2008) Richard Tomasini et al.   TRENDS IN CELL BIOLOGY