Article
Medicine, Research & Experimental
Xia Gan, Hailing Huang, Jing Wen, Kai Liu, Yuting Yang, Xiaoning Li, Gang Fang, Yonghong Liu, Xueni Wang
Summary: The natural compound alpha-terthienyl was found to inhibit the growth of prostate cancer cells by targeting the androgen receptor and its signaling pathway. It also showed anti-prostate cancer effects in a mouse xenograft model. This study highlights the potential of alpha-terthienyl as a promising small molecule for prostate cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Kumar Nikhil, Hanan S. Haymour, Mohini Kamra, Kavita Shah
Summary: This study identified that LIMK2 degrades SPOP by direct phosphorylation and creates a feedback loop to promote oncogenicity in prostate cancer. Understanding the relationship between LIMK2 and SPOP provides a powerful opportunity to inhibit LIMK2 and retain WT-SPOP, effectively halting disease progression.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Kaixuan Guo, Cheng Liu, Juanyi Shi, Cong Lai, Ze Gao, Jiawen Luo, Zhuohang Li, Zhuang Tang, Kuiqing Li, Kewei Xu
Summary: Dysregulated HMMR is associated with poor prognosis in prostate cancer. HMMR promotes PCa proliferation and metastasis through interacting with AURKA and activating the mTORC2/AKT pathway. Moreover, sustained activation of mTORC2/AKT pathway upregulates E2F1, which further promotes HMMR transcription, forming a positive feedback loop that contributes to PCa progression. Administration of mTOR inhibitor partially antagonizes HMMR-mediated PCa progression.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Katie Joanna Miller, Mohammad Asim
Summary: The androgen receptor (AR) signalling pathway plays a key role in prostate cancer. Upstream kinases promote AR signalling, while other kinases are regulated by AR. These kinases represent potential therapeutic targets for PCa.
Article
Cell Biology
Xiao-Wei Zhang, Jing-Yi Li, Lin Li, Wen-Qian Hu, Yan Tao, Wen-Yan Gao, Zi-Nuo Ye, Hao-Yuan Jia, Jia-Nan Wang, Xiao-Kang Miao, Wen-Le Yang, Rui Wang, Ling-Yun Mou
Summary: The increased expression of the cell surface receptor NK1R is associated with the progression and prognosis of treatment-related NEPC. AR inhibition enhances NK1R expression, promoting tNEPC development through the PKC & alpha;-AURKA/N-Myc pathway. Activated NK1R promotes NE transdifferentiation, cell proliferation, invasion, and enzalutamide resistance in prostate cancer cells. Targeting NK1R can inhibit NE transdifferentiation and tumor formation in vitro and in vivo.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Zhenlin Huang, Bo Tang, Yinhui Yang, Zhaogang Yang, Lei Shi, Yang Bai, Binyuan Yan, R. Jeffrey Karnes, Jun Zhang, Rafael Jimenez, Liguo Wang, Qiang Wei, Jinjian Yang, Wanhai Xu, Zhankui Jia, Haojie Huang
Summary: The study identifies a previously unrecognized tumor suppressive role of the inflammation-activated MAP3K7-IKKβ axis in degrading AR protein. Additionally, the findings suggest that aberrant elevation of AR protein could serve as a prognostic biomarker and therapeutic target for MAP3K7-deficient prostate cancer.
Article
Oncology
Yu-Ching Wen, Chien-Liang Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Van Thi Ngoc Tram, Michael Hsiao, Jiaoti Huang, Wei-Yu Chen, Yen-Nien Liu
Summary: Our study reveals that LIF/ZBTB46 signaling activation upregulates PCK1-driven glucose metabolism and neuroendocrine differentiation in CRPC. Targeting PCK1 may reduce the neuroendocrine phenotype and inhibit the growth of prostate cancer cells in vitro and in vivo, offering potential improvements in prostate cancer treatment after ADT using PCK1 inhibitors.
BRITISH JOURNAL OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Bingke Bai, Qianbo Chen, Rui Jing, Xuhui He, Hongrui Wang, Yanfei Ban, Qi Ye, Weiheng Xu, Chengjian Zheng
Summary: Prostate cancer is the second most common malignant cancer in males, and the cure remains challenging. Natural compounds have the potential to provide chemical agents for treatment. While natural products are becoming ideal choices for prostate cancer treatment, further research is still needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Developmental Biology
Casey Ah-Cann, Verena C. Wimmer, Clare E. Weeden, Claire Marceaux, Charity W. Law, Laura Galvis, Caitlin E. Filby, Joy Liu, Kelsey Breslin, Tracy Willson, Matthew E. Ritchie, Marnie E. Blewitt, Marie-Liesse Asselin-Labat
Summary: The development of a branching tree in the embryonic lung is crucial for a fully mature functional lung at birth, with Sox9(+) cells playing a key role in this process. This study identified aurora kinase b (Aurkb) as an essential regulator of Sox9(+) cells, with its loss leading to insufficient branch development. The research demonstrates the potential of genetic screens in identifying regulators of lung development.
Review
Biochemistry & Molecular Biology
Demitria M. Vasilatis, Christopher A. Lucchesi, Paramita M. Ghosh
Summary: Dogs naturally develop prostate cancer similar to aggressive forms found in humans. Prostate cancer samples in dogs often lack androgen receptor (AR), which can enhance our understanding of AR-indifferent prostate cancer in humans. This review highlights the molecular similarities between dog and human prostate cancer variants, suggesting the potential use of dogs as pre-clinical animal models for developing new therapies and diagnostics that can benefit both species.
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Cell Biology
Sadia Sarwar, Viacheslav M. Morozov, Hamsa Purayil, Yehia Daaka, Alexander M. Ishov
Summary: Androgen ablation therapy is the standard treatment for newly diagnosed prostate cancer patients. However, the relapse of castration-resistant prostate cancer (CRPC) often leads to metastasis and disease lethality. Current therapies for metastatic CRPC are limited due to resistance to Taxanes. In this study, we found that inhibition of the mitotic checkpoint kinase Mps1 enhances the efficacy of Taxanes treatment, providing a potential new therapeutic target for managing therapy-resistant metastatic CRPC.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Priya, Shalini Jaswal, Ghanshyam Das Gupta, Sant Kumar Verma
Summary: Aurora kinase family plays a critical role in cell division and the cell cycle, and overexpression of AURKA and AURKB has been linked to the development of various carcinomas. The synthesis and development of Aurora Kinase inhibitors offer new opportunities for anticancer therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Medicinal
Tathagata Pradhan, Ojasvi Gupta, Gurpreet Singh, Vikramdeep Monga
Summary: Aurora kinases, a family of regulatory proteins playing a crucial role in cell proliferation, have emerged as validated drug targets for anticancer drug discovery. The design and development of Aurora kinase inhibitors have been widely explored as potential anticancer agents, showing promising results in growth inhibition and apoptosis in tumor cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pathology
Jamshid Motaei, Arash Salmaninejad, Ebrahim Jamali, Imaneh Khorsand, Mohammad Ahmadvand, Sasan Shabani, Farshid Karimi, Mohammad Sadegh Nazari, Golsa Ketabchi, Fatemeh Naqipour
Summary: CCD is a genetic disorder characterized by abnormal clavicles, patent sutures, supernumerary teeth, and short stature, with most patients having mutations in the RUNX2 gene. Dental anomalies in CCD patients are influenced by modifier genes, environmental factors, epigenetic factors, and copy number variations in addition to RUNX2 mutations. A definitive diagnosis of CCD should involve a combination of clinical history, symptoms, signs, and genetic analyses.
FETAL AND PEDIATRIC PATHOLOGY
(2021)
Article
Pathology
Mahboobeh Rafigh, Arash Salmaninejad, Behzad Sorouri Khorashad, Azadeh Arabi, Saman Milanizadeh, Mehran Hiradfar, Mohammad Reza Abbaszadegan
Summary: This study evaluated the mutations in the HSD17B3 and SRD5A2 genes in 20 Iranian phenotypic females with 46, XY DSD. The study found that SRD5A2 and 17β-HSD3 mutations were present in 10% of Iranian patients with 46, XY DSD.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Review
Neurosciences
Arash Salmaninejad, Yousef Jafari Abarghan, Saeed Bozorg Qomi, Hadi Bayat, Meysam Yousefi, Sara Azhdari, Samaneh Talebi, Majid Mojarrad
Summary: Duchenne muscular dystrophy (DMD) is a lethal genetic disorder with serious clinical symptoms, and current main therapeutic approaches include gene therapy, cell therapy, and pharmacological therapy. Researchers have made significant progress in these areas and there is great potential for further development in the future.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Ashkan Safavi, Amirhosein Kefayat, Elham Mahdevar, Fatemeh Ghahremani, Navid Nezafat, Mohammad Hossein Modarressi
Summary: The study demonstrated that prophylactic co-immunization with multiepitope DNA and peptide cancer vaccines can significantly enhance the immune response against breast cancer, leading to reduced tumor volume and increased survival time in tumor-bearing mice. Further experiments are needed to evaluate their efficacy from different angles.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Maryam Dashtiahangar, Leila Rahbarnia, Safar Farajnia, Arash Salmaninejad, Arezoo Gowhari Shabgah, Samaneh Ghasemali
Summary: Recombinant immunotoxins (RITs) have revolutionized cancer treatment by targeting and eliminating cancerous cells through the fusion of antibodies to toxin proteins. However, high immunogenicity remains a major obstacle in clinical use, and various strategies have been proposed to address this limitation.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Multidisciplinary Sciences
Mathieu Quinodoz, Virginie G. Peter, Nicola Bedoni, Beryl Royer Bertrand, Katarina Cisarova, Arash Salmaninejad, Neda Sepahi, Raquel Rodrigues, Mehran Piran, Majid Mojarrad, Alireza Pasdar, Ali Ghanbari Asad, Ana Berta Sousa, Luisa Coutinho Santos, Andrea Superti-Furga, Carlo Rivolta
Summary: Homozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, and AutoMap efficiently identifies runs of homozygosity in WES and WGS data, showing clear benefits for molecular diagnosis and research activities in medical genetics.
NATURE COMMUNICATIONS
(2021)
Article
Pathology
Ali Sattari, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Adeleh Alihashemi, Mir Davood Omrani, Ali Zekri, Mohammad Taheri
Summary: The study highlights the significant role of IFN-gamma-associated genes in the pathogenesis of breast cancer. These genes are up-regulated in cancer tissues and show strong correlations with nearby non-cancerous tissues. AC007278.3 gene is associated with breastfeeding duration and shows the best diagnostic power among the assessed genes.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Oncology
Bita Hassani, Mohammad Taheri, Yazdan Asgari, Ali Zekri, Ali Sattari, Soudeh Ghafouri-Fard, Farkhondeh Pouresmaeili
Summary: Breast cancer is commonly associated with elevated expression of GATA3, APTR, AC144450.1, and ZNF337.AS1, while lower levels of RAMP2.AS1 are observed. The expressions of GATA3 are correlated with the cancer staging, and FOXA1 and RAMP2.AS1 are associated with mitotic rate. FOXM1 and ZNF337.AS1 are linked to breastfeeding duration. The study suggests further investigation into the functional roles of APTR, AC144450.1, and ZNF337.AS1 in breast neoplasms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Roshanak S. Sajjadi, Mohammad Hossein Modarressi, Fahimeh Akbarian, Mohammad Amin Tabatabaiefar
Summary: This study utilized computational models to investigate the role of long noncoding RNAs in prostate cancer, identifying six high-value lncRNA targets through validation experiments. It revealed the relationship between these lncRNAs and coding genes associated with prostate cancer.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Multidisciplinary Sciences
Zahra Noroozi, Mehdi Shamsara, Elahe Valipour, Sahar Esfandyari, Alireza Ehghaghi, Amir Monfaredan, Zahra Azizi, Elahe Motevaseli, Mohammad Hossein Modarressi
Summary: This study demonstrated that disrupting the HPV-E6 gene led to increased cell apoptosis and decreased cell proliferation. The antiproliferative effects of targeting HPV-E6 gene may provide therapeutic benefits for cervical cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Pouya Salehipour, Mojdeh Mahdiannasser, Ghazal Sedaghat Shayegan, Kimia Shankaie, Mina Tabrizi, Majid Mojarrad, Mohammad Hossein Modarressi
Summary: This study reports the development of a CRISPR-based fluorescent reporter (CBFR) assay for detecting the delE746_A750 subtype of EGFR exon 19 deletions. The CBFR assay offers a sensitive, specific, and simple strategy for detecting mutations, deletions, and pathogens in underequipped laboratories, and promoting personalized therapeutic approaches.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Samaneh Ghanbari, Elham Bayat, Masoumeh Azizi, Pezhman Fard-Esfahani, Mohammad Hossein Modarressi, Fatemeh Davami
Summary: Recombinant CHO cell line development traditionally relies on random integration (RI) approach, but targeted integration offers potential advantages in terms of control and stability. In this study, we used the CRISPR-mediated precise integration into target chromosome (CRIS-PITCh) system combined with the Bxb1 recombinase-mediated cassette exchange (RMCE) system to generate a transgene-expressing cell line with improved specificity and stability.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mozhgan Mondeali, Ali Etemadi, Khabat Barkhordari, Mina Mobini Kesheh, Sara Shavandi, Atefeh Bahavar, Fatemeh Hosseini Tabatabaie, Mohammad Mahmoudi Gomari, Mohammad H. Modarressi
Summary: Mutations in the spike protein of SARS-CoV-2, particularly the S477N mutation, can increase its binding affinity for ACE2 and lead to enhanced immune system evasion through new hydrogen and hydrophobic bonding. Computational analysis showed structural changes and increased stability in the spike protein due to this mutation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Samaneh Talebi, Asal Jalal Abadi, Golnesa Kazemioula, Nayyerehalsadat Hosseini, Forough Taheri, Saba Pourali, Touba Mahdloo, Marzieh Rezaei, Mohammadreza Mirinezhad, Naser Ajami, Arash Salmaninejad
Summary: This study evaluated the expression of LncRNAs in NSCLC patients in tumor tissue, adjacent non-cancerous tissue, and exosome-mediated LncRNA. It found that GHSROS, HNF1A-AS1, and HOTAIR were upregulated in tumor tissue and exosomes, while HMlincRNA717 and LINCRNA-p21 were downregulated in tumor tissue.
Article
Biotechnology & Applied Microbiology
Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Javad Zavar Reza, Mohammad Hossein Modarressi, Davood Tofighi, Bibi Fatemeh Haghiralsadat, Fatemeh Oroojalian
Summary: This study developed a nanoparticle-based delivery system consisting of selenium nanoparticles modified by chitosan and hyaluronic acid, which successfully delivered PLK1 siRNAs to bladder cancer cells. These findings suggest that hyaluronic acid-chitosan-selenium nanoparticles may provide a good vehicle for targeted gene therapy for bladder cancer.
