Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures

Differential DNA mismatch repair underlies mutation rate variation across the human genome

(2015) Fran Supek et al.   NATURE

SOD1 aggregation in ALS mice shows simplistic test tube behavior

(2015) Lisa Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

(2015) Olga V. Kochenova et al.   PLoS Genetics

Determinants of Mutation Rate Variation in the Human Germline

(2014) Laure Ségurel et al.   Annual Review of Genomics and Human Genetics

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

(2014) Scott A. Lujan et al.   GENOME RESEARCH

Error-prone polymerase activity causes multinucleotide mutations in humans

(2014) Kelley Harris et al.   GENOME RESEARCH

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

(2014) Eve Shinbrot et al.   GENOME RESEARCH

Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress

(2014) Ilya N. Kotov et al.   Molecular Oncology

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences

(2014) Savithri Weerasooriya et al.   PLoS One

Human Pol   purified with accessory subunits is active in translesion DNA synthesis and complements Pol   in cisplatin bypass

(2014) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage

(2014) Chris M. Rands et al.   PLoS Genetics

The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis

(2013) Kin Chan et al.   DNA REPAIR

Rates and Genomic Consequences of Spontaneous Mutational Events in Drosophila melanogaster

(2013) Daniel R. Schrider et al.   GENETICS

Patterns and Mutational Signatures of Tandem Base Substitutions Causing Human Inherited Disease

(2013) Jian-Min Chen et al.   HUMAN MUTATION

A New and More Accurate Estimate of the Rate of Concurrent Tandem-Base Substitution Mutations in the Human Germline: ∼0.4% of the Single-Nucleotide Substitution Mutation Rate

(2013) Jian-Min Chen et al.   HUMAN MUTATION

Prevalence of Multinucleotide Replacements in Evolution of Primates and Drosophila

(2013) Nadezhda V. Terekhanova et al.   MOLECULAR BIOLOGY AND EVOLUTION

Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

(2013) Paz Polak et al.   NATURE BIOTECHNOLOGY

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

(2013) Matthew R. Northam et al.   NUCLEIC ACIDS RESEARCH

The UCSC Genome Browser database: 2014 update

(2013) Donna Karolchik et al.   NUCLEIC ACIDS RESEARCH

Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline

(2013) E. Giannoulatou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Relationship of DNA Replication Timing to Different Forms of Human Mutation and Variation

(2012) Amnon Koren et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic evidence for elevated mutation rates in highly expressed genes

(2012) Chungoo Park et al.   EMBO REPORTS

Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

(2012) Irina S.-R. Waisertreiger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions inSaccharomyces cerevisiae

(2012) Jana E. Stone et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions

(2012) Huseyin Saribasak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heterogeneity of the Transition/Transversion Ratio in Drosophila and Hominidae Genomes

(2012) V. B. Seplyarskiy et al.   MOLECULAR BIOLOGY AND EVOLUTION

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

DNA polymerase zeta is required for proliferation of normal mammalian cells

(2012) Sabine S. Lange et al.   NUCLEIC ACIDS RESEARCH

Major role of positive selection in the evolution of conservative segments of Drosophila proteins

(2012) G. A. Bazykin et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes

(2012) Yong H Woo et al.   Nature Communications

Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines

(2012) Antoine Baker et al.   PLoS Computational Biology

Pervasive Multinucleotide Mutational Events in Eukaryotes

(2011) Daniel R. Schrider et al.   CURRENT BIOLOGY

Mutation Rate Distribution Inferred from Coincident SNPs and Coincident Substitutions

(2011) Philip L. F. Johnson et al.   Genome Biology and Evolution

Mutation Rates across Budding Yeast Chromosome VI Are Correlated with Replication Timing

(2011) Gregory I. Lang et al.   Genome Biology and Evolution

A novel codon4 mutation (A4F) in the SOD1gene in familial amyotrophic lateral sclerosis

(2011) Wonki Baek et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Positive and Negative Selection in Murine Ultraconserved Noncoding Elements

(2011) Daniel L. Halligan et al.   MOLECULAR BIOLOGY AND EVOLUTION

Replication-Associated Mutational Asymmetry in the Human Genome

(2011) Chun-Long Chen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Late-Replicating Domains Have Higher Divergence and Diversity in Drosophila melanogaster

(2011) Claudia C. Weber et al.   MOLECULAR BIOLOGY AND EVOLUTION

The evolution of gene expression levels in mammalian organs

(2011) David Brawand et al.   NATURE

Variation in the mutation rate across mammalian genomes

(2011) Alan Hodgkinson et al.   NATURE REVIEWS GENETICS

REV1 and polymerase ζ facilitate homologous recombination repair

(2011) Shilpy Sharma et al.   NUCLEIC ACIDS RESEARCH

Correlated Evolution of Nearby Residues in Drosophilid Proteins

(2011) Benjamin Callahan et al.   PLoS Genetics

Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes

(2010) C. L. Chen et al.   GENOME RESEARCH

Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types

(2010) T. Ryba et al.   GENOME RESEARCH

Don't forget the ancestral polymorphisms

(2010) D Charlesworth   HEREDITY

Comparative Analysis of DNA Replication Timing Reveals Conserved Large-Scale Chromosomal Architecture

(2010) Eitan Yaffe et al.   PLoS Genetics

Participation of DNA Polymerase   in Replication of Undamaged DNA in Saccharomyces cerevisiae

(2009) M. R. Northam et al.   GENETICS

Human mutation rate associated with DNA replication timing

(2009) John A Stamatoyannopoulos et al.   NATURE GENETICS

Effective population size and patterns of molecular evolution and variation

(2009) Brian Charlesworth   NATURE REVIEWS GENETICS

Widespread Genomic Signatures of Natural Selection in Hominid Evolution

(2009) Graham McVicker et al.   PLoS Genetics

Transcription induces strand-specific mutations at the 5' end of human genes

(2008) P. Polak et al.   GENOME RESEARCH