Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ

(2012) Jessica S. Williams et al.   DNA REPAIR

The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ

(2012) Yulia Pustovalova et al.   FEBS LETTERS

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

(2012) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Bridging [4Fe-4S] Cluster and Nucleotide Binding Are Essential for Function of the Cfd1-Nbp35 Complex as a Scaffold in Iron-Sulfur Protein Maturation

(2012) Daili J. A. Netz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Intrinsic coupling of lagging-strand synthesis to chromatin assembly

(2012) Duncan J. Smith et al.   NATURE

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1

(2012) Jason W. Gloor et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase zeta is required for proliferation of normal mammalian cells

(2012) Sabine S. Lange et al.   NUCLEIC ACIDS RESEARCH

Pivotal Role of Inosine Triphosphate Pyrophosphatase in Maintaining Genome Stability and the Prevention of Apoptosis in Human Cells

(2012) Miriam Rose Menezes et al.   PLoS One

Interplay between mismatch repair and chromatin assembly

(2012) B. Schopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pol31 and Pol32 subunits of yeast DNA polymerase   are also essential subunits of DNA polymerase  

(2012) R. E. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

(2012) B. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism

(2012) K. Gari et al.   SCIENCE

X-ray structure of the complex of regulatory subunits of human DNA polymerase delta

(2011) Andrey G. Baranovskiy et al.   CELL CYCLE

Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond

(2011) Junjie U. Guo et al.   CELL CYCLE

Damage-induced localized hypermutability

(2011) Lauranell H. Burch et al.   CELL CYCLE

The in vitro fidelity of yeast DNA polymerase δ and polymerase ɛ holoenzymes during dinucleotide microsatellite DNA synthesis

(2011) Amy L. Abdulovic et al.   DNA REPAIR

Timing and spacing of ubiquitin-dependent DNA damage bypass

(2011) Helle D. Ulrich   FEBS LETTERS

Inosine Triphosphate Protects Against Ribavirin-Induced Adenosine Triphosphate Loss by Adenylosuccinate Synthase Function

(2011) Yuki Hitomi et al.   GASTROENTEROLOGY

Initiation of chromosomal DNA replication in eukaryotic cells; contribution of yeast genetics to the elucidation

(2011) Hiroyuki Araki   GENES & GENETIC SYSTEMS

Mutation Rates across Budding Yeast Chromosome VI Are Correlated with Replication Timing

(2011) Gregory I. Lang et al.   Genome Biology and Evolution

The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis

(2011) Neeru M. Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

(2011) Vladimir P. Bermudez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of DNA replication and histone modification by the Rik1–Dos2 complex

(2011) Fei Li et al.   NATURE

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

(2011) Rafael Núñez-Ramírez et al.   NUCLEIC ACIDS RESEARCH

The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA

(2011) Irene Saugar et al.   NUCLEIC ACIDS RESEARCH

Replication Protein A (RPA) Hampers the Processive Action of APOBEC3G Cytosine Deaminase on Single-Stranded DNA

(2011) Artem G. Lada et al.   PLoS One

CAF-I-dependent control of degradation of the discontinuous strands during mismatch repair

(2011) L. Y. Kadyrova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Okazaki fragment maturation: nucleases take centre stage

(2011) L. Zheng et al.   Journal of Molecular Cell Biology

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

(2011) Izumi Miyabe et al.   PLoS Genetics

Chaperoning Histones during DNA Replication and Repair

(2010) Monica Ransom et al.   CELL

Functions of base selection step in human DNA polymerase α

(2010) Shigeru Tanaka et al.   DNA REPAIR

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells

(2010) Kunihiko Sakumi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases

(2010) Hiroyuki Kamiya   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C

(2010) Jacques Fellay et al.   NATURE

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis

(2010) Daili J A Netz et al.   Nature Chemical Biology

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

(2010) Nona Abolhassani et al.   NUCLEIC ACIDS RESEARCH

The high fidelity and unique error signature of human DNA polymerase  

(2010) D. A. Korona et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

(2010) D. Kumar et al.   NUCLEIC ACIDS RESEARCH

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase

(2010) S. Vaithiyalingam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide model for the normal eukaryotic DNA replication fork

(2010) Andres A. Larrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

The eukaryotic replicative DNA polymerases take shape

(2010) Erik Johansson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

(2010) Anna Aksenova et al.   PLoS Genetics

Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase

(2009) Greg Herting et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanism and evolution of DNA primases

(2009) Robert D. Kuchta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

(2009) Tahir H Tahirov et al.   Biology Direct

Functional mapping of the fission yeast DNA polymerase δ B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis

(2009) Javier Sanchez Garcia et al.   BMC MOLECULAR BIOLOGY

ITPase-deficient mice show growth retardation and die before weaning

(2009) M Behmanesh et al.   CELL DEATH AND DIFFERENTIATION

Pro32Thr Polymorphism of Inosine Triphosphate Pyrophosphatase Gene Predicts Efficacy of Low-Dose Azathioprine for Patients With Systemic Lupus Erythematosus

(2009) Y Okada et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases

(2009) Sebastian Klinge et al.   EMBO JOURNAL

Participation of DNA Polymerase   in Replication of Undamaged DNA in Saccharomyces cerevisiae

(2009) M. R. Northam et al.   GENETICS

Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

(2009) Elena I. Stepchenkova et al.   JOURNAL OF MOLECULAR BIOLOGY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

(2009) Alexander A. Shishkin et al.   MOLECULAR CELL

Production of clastogenic DNA precursors by the nucleotide metabolism inEscherichia coli

(2009) Brian Budke et al.   MOLECULAR MICROBIOLOGY

Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae

(2009) Malgorzata Jaszczur et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

DNA polymerases at the eukaryotic fork—20 years later

(2009) Youri I. Pavlov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

DNA damage tolerance: when it's OK to make mistakes

(2009) Debbie J Chang et al.   Nature Chemical Biology

Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair

(2009) Bjørn Dalhus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Yeast Rev1 protein promotes complex formation of DNA polymerase   with Pol32 subunit of DNA polymerase  

(2009) N. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cancer-associated DNA polymerase   variant modeled in yeast causes a catastrophic increase in genomic instability

(2009) D. L. Daee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase   and   proofreading suppress discrete mutator and cancer phenotypes in mice

(2009) T. M. Albertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing AID and DNA repair during somatic hypermutation

(2009) Man Liu et al.   TRENDS IN IMMUNOLOGY

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

(2008) Scott D McCulloch et al.   CELL RESEARCH

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

(2008) G Stocco et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Dpb2p, a Noncatalytic Subunit of DNA Polymerase  , Contributes to the Fidelity of DNA Replication in Saccharomyces cerevisiae

(2008) M. Jaszczur et al.   GENETICS

Impact of Phosphorylation and Phosphorylation-null Mutants on the Activity and Deamination Specificity of Activation-induced Cytidine Deaminase

(2008) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymerase Dynamics at the Eukaryotic DNA Replication Fork

(2008) Peter M. J. Burgers   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dynamic Polymerase Exchange withEscherichia coliDNA Polymerase IV Replacing DNA Polymerase III on the Sliding Clamp

(2008) Asako Furukohri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues

(2008) Stanislav G. Kozmin et al.   MOLECULAR MICROBIOLOGY

The solution structure of the amino-terminal domain of human DNA polymerase ε subunit B is homologous to C-domains of AAA+ proteins

(2008) Tarmo Nuutinen et al.   NUCLEIC ACIDS RESEARCH

Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G

(2008) L. Chelico et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Chromatin-Associated Periodicity in Genetic Variation Downstream of Transcriptional Start Sites

(2008) S. Sasaki et al.   SCIENCE

Dividing the workload at a eukaryotic replication fork

(2008) Thomas A. Kunkel et al.   TRENDS IN CELL BIOLOGY

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

(2008) Gabriele De Luca et al.   PLoS Genetics

Mechanism of oxidative DNA damage repair and relevance to human pathology

(2007) M DERRICO et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH