Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH)
出版年份 2014 全文链接
标题
Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH)
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 5, Pages 7352-7379
出版商
MDPI AG
发表日期
2014-04-30
DOI
10.3390/ijms15057352
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis
- (2014) Amit G Singal et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Antibiotic treatments and microbes in the gut
- (2014) Sandra Macfarlane ENVIRONMENTAL MICROBIOLOGY
- Interactions Between the Intestinal Microbiome and Liver Diseases
- (2014) Bernd Schnabl et al. GASTROENTEROLOGY
- High-fat diet triggers Mallory-Denk body formation through misfolding and crosslinking of excess keratin 8
- (2014) Ozlem Kucukoglu et al. HEPATOLOGY
- Glucose-Induced Glucagon-Like Peptide 1 Secretion Is Deficient in Patients with Non-Alcoholic Fatty Liver Disease
- (2014) Christine Bernsmeier et al. PLoS One
- Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis
- (2013) J. H. Hoofnagle et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Serum Cytokeratin-18 Fragment Levels Are Useful Biomarkers for Nonalcoholic Steatohepatitis in Children
- (2013) Ariel E Feldstein et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Opportunistic Infections With Anti-Tumor Necrosis Factor-α Therapy in Inflammatory Bowel Disease: Meta-Analysis of Randomized Controlled Trials
- (2013) Alexander C Ford et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet
- (2013) Masateru Ushio et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Lycopene Metabolite, Apo-10'-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet-Promoted Hepatic Inflammation and Tumorigenesis in Mice
- (2013) B. C. Ip et al. Cancer Prevention Research
- NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
- (2013) Pingping Li et al. CELL
- Iron Deficiency in Patients With Nonalcoholic Fatty Liver Disease Is Associated With Obesity, Female Gender, and Low Serum Hepcidin
- (2013) Asma Siddique et al. Clinical Gastroenterology and Hepatology
- Recent advancements in drug treatment of obesity
- (2013) R. Carter et al. CLINICAL MEDICINE
- Epidemiology and Natural History of Patients with NAFLD
- (2013) Neeraj Bhala et al. CURRENT PHARMACEUTICAL DESIGN
- Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3
- (2013) S. Lallukka et al. DIABETOLOGIA
- Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals
- (2013) Elisa Fabbrini et al. GASTROENTEROLOGY
- Intestinal microbiota in patients with nonalcoholic fatty liver disease
- (2013) Marialena Mouzaki et al. HEPATOLOGY
- Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
- (2013) Kengo Tomita et al. HEPATOLOGY
- Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis
- (2013) Priya Handa et al. HEPATOLOGY
- IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice
- (2013) Isaac T.W. Harley et al. HEPATOLOGY
- The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
- (2013) Victoria L. Gadd et al. HEPATOLOGY
- Relationship between sarcopenia and nonalcoholic fatty liver disease: The Korean Sarcopenic Obesity Study
- (2013) Ho Cheol Hong et al. HEPATOLOGY
- Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy
- (2013) Virginia Hernández-Gea et al. JOURNAL OF HEPATOLOGY
- Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease
- (2013) Kenneth Cusi et al. JOURNAL OF HEPATOLOGY
- Genetic variation in thePNPLA3gene and hepatocellular carcinoma in USA: Risk and prognosis prediction
- (2013) Manal M. Hassan et al. MOLECULAR CARCINOGENESIS
- Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
- (2013) Shin Yoshimoto et al. NATURE
- A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
- (2013) Miki Okada-Iwabu et al. NATURE
- Butyrate-Producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-Liver Axis
- (2013) Hitoshi Endo et al. PLoS One
- No Correlation between PNPLA3 rs738409 Genotype and Fatty Liver and Hepatic Cirrhosis in Japanese Patients with HCV
- (2013) Masato Nakamura et al. PLoS One
- The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease
- (2013) April D. Lake et al. TOXICOLOGICAL SCIENCES
- Ten misconceptions about antioxidants
- (2013) Aalt Bast et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection
- (2013) J. R. Barker et al. mBio
- Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention
- (2013) Blanche Ip et al. Nutrients
- Oxidants, antioxidants and the current incurability of metastatic cancers
- (2013) J. Watson Open Biology
- Immunological functions of leptin and adiponectin
- (2012) Fortunata Carbone et al. BIOCHIMIE
- Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease
- (2012) Masato Yoneda et al. BMC GASTROENTEROLOGY
- Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice
- (2012) Jae-Seon So et al. Cell Metabolism
- Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
- (2012) G. Musso et al. DIABETOLOGIA
- Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues
- (2012) Virginia Hernández–Gea et al. GASTROENTEROLOGY
- The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
- (2012) Naga Chalasani et al. GASTROENTEROLOGY
- Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
- (2012) Giovanni Musso et al. HEPATOLOGY
- Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
- (2012) Bo Wang et al. HEPATOLOGY
- Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice
- (2012) Daisuke Kawai et al. HEPATOLOGY
- Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism
- (2012) Claudia O. Zein et al. HEPATOLOGY
- The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
- (2012) Naga Chalasani et al. HEPATOLOGY
- Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice
- (2012) Kouichi Miura et al. HEPATOLOGY
- Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
- (2012) John Zhong Li et al. JOURNAL OF CLINICAL INVESTIGATION
- The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis
- (2012) Yasuto Takeuchi et al. JOURNAL OF GASTROENTEROLOGY
- Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
- (2012) Anne Leroux et al. JOURNAL OF HEPATOLOGY
- Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal
- (2012) Mariana V. Machado et al. JOURNAL OF HEPATOLOGY
- A 360-degree overview of paediatric NAFLD: Recent insights
- (2012) Valerio Nobili et al. JOURNAL OF HEPATOLOGY
- Dietary trans-Fatty Acid Induced NASH is Normalized Following Loss of trans-Fatty Acids from Hepatic Lipid Pools
- (2012) Brent A. Neuschwander-Tetri et al. LIPIDS
- Endoplasmic Reticulum stress induces hepatic stellate cell apoptosis and contributes to fibrosis resolution
- (2012) Samuele De Minicis et al. LIVER INTERNATIONAL
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
- (2012) Jorge Henao-Mejia et al. NATURE
- Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
- (2012) Saswata Talukdar et al. NATURE MEDICINE
- Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
- (2012) Young-il Kim et al. PLoS One
- Linagliptin Improves Insulin Sensitivity and Hepatic Steatosis in Diet-Induced Obesity
- (2012) Matthias Kern et al. PLoS One
- Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
- (2012) Takahisa Kawaguchi et al. PLoS One
- Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
- (2012) Daniel J. Cuthbertson et al. PLoS One
- Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
- (2012) Giovanni Musso et al. PROGRESS IN LIPID RESEARCH
- Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
- (2012) Toshifumi Yae et al. Nature Communications
- Toll-like receptors 1–9 are elevated in livers with fructose-induced hepatic steatosis
- (2011) Sabine Wagnerberger et al. BRITISH JOURNAL OF NUTRITION
- Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications
- (2011) Shigeo Ohta CURRENT PHARMACEUTICAL DESIGN
- Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
- (2011) Anabela P. Rolo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput Sequencing
- (2011) Maria Gloria Dominguez-Bello et al. GASTROENTEROLOGY
- Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
- (2011) Claudia O. Zein et al. HEPATOLOGY
- Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
- (2011) Aijun Qiao et al. HEPATOLOGY
- Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
- (2011) Timea Csak et al. HEPATOLOGY
- Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
- (2011) Silvia Sookoian et al. HEPATOLOGY
- Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model
- (2011) Ren-ying Xu et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Stage of hepatocellular carcinoma is associated with periodontitis
- (2011) Naofumi Tamaki et al. JOURNAL OF CLINICAL PERIODONTOLOGY
- TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T Cell Responses to a Flagellated Pathogen
- (2011) S. E. Letran et al. JOURNAL OF IMMUNOLOGY
- Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice
- (2011) Michal Aharoni-Simon et al. LABORATORY INVESTIGATION
- Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
- (2011) Gianluca Svegliati-Baroni et al. LIVER INTERNATIONAL
- Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
- (2011) Suneng Fu et al. NATURE
- Management of metabolic syndrome in children and adolescents
- (2011) L. Pacifico et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- ROS signaling: the new wave?
- (2011) Ron Mittler et al. TRENDS IN PLANT SCIENCE
- Ursodeoxycholic acid with vitamin E in patients with nonalcoholic steatohepatitis: Long-term results
- (2011) Florence Pietu et al. Clinics and Research in Hepatology and Gastroenterology
- L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function
- (2011) Yunqiu Xia et al. Diabetology & Metabolic Syndrome
- l-Carnitine Supplementation to Diet: A New Tool in Treatment of Nonalcoholic Steatohepatitis—A Randomized and Controlled Clinical Trial
- (2010) Mariano Malaguarnera et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
- (2010) Giovanni Musso et al. ANNALS OF MEDICINE
- Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
- (2010) Richard C. Scarpulla BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
- (2010) Chantal A Rivera et al. BMC GASTROENTEROLOGY
- The sites and topology of mitochondrial superoxide production
- (2010) Martin D. Brand EXPERIMENTAL GERONTOLOGY
- Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease
- (2010) S. McPherson et al. GUT
- High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial
- (2010) Ulrich F. H. Leuschner et al. HEPATOLOGY
- I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
- (2010) Luca Valenti et al. HEPATOLOGY
- Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
- (2010) James E. Nelson et al. HEPATOLOGY
- Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study
- (2010) Masato Yoneda et al. HEPATOLOGY RESEARCH
- Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults
- (2010) Bret H. Goodpaster et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The protective role of hydrogen-rich saline in experimental liver injury in mice
- (2010) HanYong Sun et al. JOURNAL OF HEPATOLOGY
- Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis
- (2010) Stergios A. Polyzos et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation
- (2010) Sang Won Park et al. NATURE MEDICINE
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity
- (2010) S. W. Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
- (2010) M. Vijay-Kumar et al. SCIENCE
- Kupffer cell activation is a causal factor for hepatic insulin resistance
- (2009) Nicolas Lanthier et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
- (2009) P. D. Cani et al. GUT
- Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
- (2009) Luca Miele et al. HEPATOLOGY
- A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis
- (2009) Austin Nelson et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
- (2009) Satoshi Nishimura et al. NATURE MEDICINE
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Why Have Antioxidants Failed in Clinical Trials?
- (2008) Steven R. Steinhubl AMERICAN JOURNAL OF CARDIOLOGY
- Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage
- (2008) William S. Blaner et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- TheDGAT2gene is a candidate for the dissociation between fatty liver and insulin resistance in humans
- (2008) Konstantinos Kantartzis et al. CLINICAL SCIENCE
- Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice
- (2008) P. D. Cani et al. DIABETES
- Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model
- (2008) G. Serviddio et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
- (2008) Elizabeth M. Brunt et al. HEPATOLOGY
- Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease
- (2008) Hong Ma et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C
- (2008) Satoru Yatsuji et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
- (2008) Christopher L. Gentile et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- Pattern of Expression of Adiponectin Receptors in Human Liver and its Relation to Nonalcoholic Steatohepatitis
- (2008) M. Nannipieri et al. OBESITY SURGERY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search