Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

Cytoprotective and nonprotective autophagy in cancer therapy

(2013) David A. Gewirtz   Autophagy

Mechanisms of Radiation Toxicity in Transformed and Non-Transformed Cells

(2013) Ronald-Allan Panganiban et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The DNA damage response during mitosis

(2013) Anne Margriet Heijink et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Macroautophagy-aided elimination of chromatin

(2012) Jekaterina Erenpreisa et al.   Autophagy

p21WAF1 and tumourigenesis

(2012) Noel A. Warfel et al.   CURRENT OPINION IN ONCOLOGY

New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy

(2012) Razmik Mirzayans et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A Two-Step Mechanism for Cell Fate Decision by Coordination of Nuclear and Mitochondrial p53 Activities

(2012) Xiao-Jun Tian et al.   PLoS One

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Molecular Machinery of Autophagy and Its Implication in Cancer

(2011) Yumin Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

(2011) M. Wang et al.   CANCER RESEARCH

Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation

(2011) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

p21WAF1is component of a positive feedback loop that maintains the p53 transcriptional program

(2011) Lisa Y. Pang et al.   CELL CYCLE

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

ATRcontrols the p21WAF1/Cip1protein up-regulation and apoptosis in response to low UV fluences

(2011) Huda H. Al-Khalaf et al.   MOLECULAR CARCINOGENESIS

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers

(2011) Matthew A. Nehs et al.   SURGERY

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

(2010) Ilio Vitale et al.   EMBO JOURNAL

Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation

(2010) Yun Xia et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Coordination between Cell Cycle Progression and Cell Fate Decision by the p53 and E2F1 Pathways in Response to DNA Damage

(2010) Xiao-Peng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair

(2010) Sung-Hwan Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

MOS, aneuploidy and the ploidy cycle of cancer cells

(2010) J Erenpreisa et al.   ONCOGENE

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Autophagy, senescence and tumor dormancy in cancer therapy

(2009) David A. Gewirtz   Autophagy

Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response

(2009) X. Zhang et al.   CANCER RESEARCH

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

(2009) F. Ianzini et al.   CANCER RESEARCH

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

The anti-apoptotic role for p53 following exposure to ultraviolet light does not involve DDB2

(2009) L.J. Stubbert et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Cell fate decision mediated by p53 pulses

(2009) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MCF-7 breast carcinoma cells do not express caspase-3

(2008) Reiner U. Jänicke   BREAST CANCER RESEARCH AND TREATMENT

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

(2008) E. Crescenzi et al.   CLINICAL CANCER RESEARCH

Molecular Architecture of Tumor Suppressor p53

(2008) Hector Viadiu   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL

(2008) Patrick J. Rochette et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Ultraviolet light exposure triggers nuclear accumulation of p21WAF1and accelerated senescence in human normal and nucleotide excision repair-deficient fibroblast strains

(2007) Razmik Mirzayans et al.   JOURNAL OF CELLULAR PHYSIOLOGY