标题
Hedgehog Signaling in Prostate Cancer and Its Therapeutic Implication
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 7, Pages 13979-14007
出版商
MDPI AG
发表日期
2013-07-05
DOI
10.3390/ijms140713979
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Protease nexin 1: a novel regulator of prostate cancer cell growth and neo-angiogenesis
- (2015) Chad M. McKee et al. Oncotarget
- Hedgehog Pathway Inhibitor HhAntag691 Is a Potent Inhibitor of ABCG2/BCRP and ABCB1/Pgp
- (2015) Yimao Zhang et al. NEOPLASIA
- Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
- (2013) James Kim et al. CANCER CELL
- Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer
- (2013) Rhonda L Bitting et al. ENDOCRINE-RELATED CANCER
- TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling
- (2013) Naokazu Ibuki et al. INTERNATIONAL JOURNAL OF CANCER
- Hedgehog Signaling Pathway in Ovarian Cancer
- (2013) Joanna Szkandera et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer
- (2013) Yi Chen et al. MOLECULAR CARCINOGENESIS
- NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128
- (2013) R Nanta et al. Oncogenesis
- Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection
- (2012) Sonia Coni et al. BIOCHEMICAL PHARMACOLOGY
- Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells
- (2012) Josep Domingo-Domenech et al. CANCER CELL
- The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
- (2012) Yan Wang et al. CANCER CELL
- GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft
- (2012) Junsheng Fu et al. CANCER LETTERS
- Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells
- (2012) D. J. Mulholland et al. CANCER RESEARCH
- Vismodegib
- (2012) C. M. Rudin CLINICAL CANCER RESEARCH
- Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling
- (2012) N. B. Hassounah et al. CLINICAL CANCER RESEARCH
- Hedgehog Pathway Inhibition Radiosensitizes Non-Small Cell Lung Cancers
- (2012) Jing Zeng et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Hedgehog pathway inhibition and the race against tumor evolution
- (2012) Scott X. Atwood et al. JOURNAL OF CELL BIOLOGY
- Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma
- (2012) Chad M. McKee et al. JOURNAL OF CLINICAL INVESTIGATION
- Resolving the stem-cell debate
- (2012) Richard J. Gilbertson et al. NATURE
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
- (2012) Jean Y. Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
- (2012) Aleksandar Sekulic et al. NEW ENGLAND JOURNAL OF MEDICINE
- Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
- (2012) Howard I. Scher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chemoresistance in Prostate Cancer Cells Is Regulated by miRNAs and Hedgehog Pathway
- (2012) Saurabh Singh et al. PLoS One
- Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers
- (2012) Eleni Efstathiou et al. PROSTATE
- Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b
- (2012) Maria Karlou et al. PROSTATE
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation
- (2011) Naz Chaudary et al. CANCER
- Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells
- (2011) T. Mazumdar et al. CANCER RESEARCH
- Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer
- (2011) Hideya Onishi et al. CANCER SCIENCE
- Hedgehog signaling pathway as a therapeutic target in various types of cancer
- (2011) Hideya Onishi et al. CANCER SCIENCE
- Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells
- (2011) Mengqian Chen et al. CELL CYCLE
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Pathways of chemotherapy resistance in castration-resistant prostate cancer
- (2011) K. L. Mahon et al. ENDOCRINE-RELATED CANCER
- Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling
- (2011) Vassiliki Tzelepi et al. HISTOPATHOLOGY
- Sonic Hedgehog Signaling Protects Human Hepatocellular Carcinoma Cells Against Ionizing Radiation in an Autocrine Manner
- (2011) Yu-Jen Chen et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Hedgehog signaling protein expression and its association with prognostic parameters in prostate cancer: A retrospective study from the view point of new 2010 anatomic stage/prognostic groups
- (2011) Tae-Jung Kim et al. JOURNAL OF SURGICAL ONCOLOGY
- Combination of Hedgehog Signaling Blockage and Chemotherapy Leads to Tumor Reduction in Pancreatic Adenocarcinomas
- (2011) Marcus Bahra et al. PANCREAS
- GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor
- (2010) Guangchun Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
- (2010) Christophe Mas et al. BIOCHEMICAL PHARMACOLOGY
- Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia
- (2010) Guansong Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- Integration of Epidermal Growth Factor Receptor Inhibitors with Preoperative Chemoradiation
- (2010) A. Debucquoy et al. CLINICAL CANCER RESEARCH
- Estimates of cancer incidence and mortality in Europe in 2008
- (2010) J. Ferlay et al. EUROPEAN JOURNAL OF CANCER
- Outcome Predictors of Radical Prostatectomy in Patients With Prostate-Specific Antigen Greater Than 20 ng/ml: A European Multi-Institutional Study of 712 Patients
- (2010) Martin Spahn et al. EUROPEAN UROLOGY
- Correlation of Hedgehog Signal Activation with Chemoradiotherapy Sensitivity and Survival in Esophageal Squamous Cell Carcinomas
- (2010) W. Zhu et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells
- (2010) Mengqian Chen et al. Molecular Cancer
- Cytotoxic Effects Induced by Docetaxel, Gefitinib, and Cyclopamine on Side Population and Nonside Population Cell Fractions from Human Invasive Prostate Cancer Cells
- (2010) M. Mimeault et al. MOLECULAR CANCER THERAPEUTICS
- Hedgehog Promotes Neovascularization in Pancreatic Cancers by Regulating Ang-1 and IGF-1 Expression in Bone-Marrow Derived Pro-Angiogenic Cells
- (2010) Kazumasa Nakamura et al. PLoS One
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals
- (2010) B. Stecca et al. Journal of Molecular Cell Biology
- Sonic Hedgehog pathway activity in prostate cancer
- (2010) OLGA BRAGINA et al. Oncology Letters
- Targeting p53 for enhanced radio- and chemo-sensitivity
- (2009) Chao Lu et al. APOPTOSIS
- Hedgehog signaling regulates proliferation of prostate cancer cells via stathmin1
- (2009) Moon-Kee Chung et al. CLINICAL AND EXPERIMENTAL MEDICINE
- Small-molecule modulators of the Sonic Hedgehog signaling pathway
- (2009) Benjamin Z. Stanton et al. Molecular BioSystems
- Dual and opposing roles of primary cilia in medulloblastoma development
- (2009) Young-Goo Han et al. NATURE MEDICINE
- Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
- (2009) Sunny Y Wong et al. NATURE MEDICINE
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
- (2009) L Yang et al. ONCOGENE
- Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency
- (2009) Pierre-Olivier Frappart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
- (2009) R. Rohatgi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Receptor signaling as a regulatory mechanism of DNA repair
- (2009) Raymond E. Meyn et al. RADIOTHERAPY AND ONCOLOGY
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy
- (2008) R Yoshikawa et al. BRITISH JOURNAL OF CANCER
- Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
- (2008) Hiromichi Kimura et al. CANCER CELL
- Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling
- (2008) Greg Shaw et al. Cancer Cell International
- GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer
- (2008) S. Narita et al. CLINICAL CANCER RESEARCH
- Hedgehog Signaling in Development and Cancer
- (2008) Jin Jiang et al. DEVELOPMENTAL CELL
- Hedgehog Signalling in Androgen Independent Prostate Cancer
- (2008) Greg Shaw et al. EUROPEAN UROLOGY
- Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
- (2008) Jennifer M. Leonard et al. JOURNAL OF CELL BIOLOGY
- Cancer stem cells: implications for the progression and treatment of metastatic disease
- (2008) A.K Croker et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hypoxia induces a hedgehog response mediated by HIF-1α
- (2008) Maarten F. Bijlsma et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression
- (2008) S Azoulay et al. JOURNAL OF PATHOLOGY
- Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer
- (2008) Johan Bussink et al. LANCET ONCOLOGY
- Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target
- (2008) G. V. Hegde et al. MOLECULAR CANCER RESEARCH
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
- Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin–proteasome pathway
- (2008) S Yue et al. ONCOGENE
- Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
- (2008) Y. Abe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now