Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats

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TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

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Halofuginone — The Multifaceted Molecule

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Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice

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PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

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Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis

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IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass

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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

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Halofuginone Ameliorates Autoimmune Arthritis in Mice by Regulating the Balance Between Th17 and Treg Cells and Inhibiting Osteoclastogenesis

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Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

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ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase

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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

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Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

(2012) Steven R. Goldring   Therapeutic Advances in Musculoskeletal Disease

ALK1 as an emerging target for antiangiogenic therapy of cancer

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Targeting osteoclast-osteoblast communication

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Osteoarthritis year 2010 in review: non-pharmacologic therapy

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T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

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Osteoarthritis year 2010 in review: pharmacological therapies

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The subchondral bone: a new frontier in articular cartilage repair

(2010) Henning Madry   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The basic science of the subchondral bone

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The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

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Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis

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Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study

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TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

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Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response

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Focusing on fibrosis: halofuginone-induced functional improvement in the mdx mouse model of Duchenne muscular dystrophy

(2008) Linda K. McLoon   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis

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Angiogenesis in two animal models of osteoarthritis

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