Article
Plant Sciences
Mohamed R. Habib, Ahmed A. Hamed, Rasha E. M. Ali, Khaled M. Zayed, Rasha M. Gad El-Karim, Rehab Sabour, Hanaa M. Abu El-Einin, Mosad A. Ghareeb
Summary: This study investigated the chemical profile and biological activities of tissue extracts from Thais savignyi. The ethyl acetate extract showed the highest antioxidant capacity, antibacterial, antibiofilm, antifungal, and cytotoxic activities.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Chemistry, Physical
Mariana Constantin, Iuliana Raut, Raluca Suica-Bunghez, Cristina Firinca, Nicoleta Radu, Ana-Maria Gurban, Silviu Preda, Elvira Alexandrescu, Mihaela Doni, Luiza Jecu
Summary: Green chemistry is a simple method that produces stable and well-dispersed nanoparticles in water. This study used aqueous mycelial extracts of Ganoderma lucidum to synthesize silver nanoparticles. The nanoparticles were characterized using various techniques such as UV-visible spectroscopy, SEM, XRD, and FTIR analysis. The synthesized nanoparticles showed antimicrobial effectiveness against bacterial and yeast strains, reducing environmental and public health risks.
Article
Microbiology
Zi-Xu Wang, Na Li, Jun-Wei Xu
Summary: Efficient expression of the Vitreoscilla hemoglobin gene in G. lucidum increased the production of exopolysaccharides and enhanced their antioxidant activity, without changing their monosaccharide composition or molecular weight distribution.
Article
Chemistry, Medicinal
Yu-Xin Lin, Jin-Tao Sun, Zheng-Zheng Liao, Yan Sun, Xiang-Ge Tian, Ling-Ling Jin, Chao Wang, Ai-Jing Leng, Jian Zhou, Da-Wei Li
Summary: Four new lanostane triterpenoids were isolated from the fruiting bodies of Ganoderma lucidum, which showed potential application for anti-neuroinflammation by inhibiting the activity of FAAH without cytotoxicity.
Article
Biology
El Hadi Erbiai, Benoutman Amina, Abbassi Kaoutar, Rabah Saidi, Zouhaire Lamrani, Eugenia Pinto, Joaquim C. G. Esteves da Silva, Abdelfettah Maouni, Luis Pinto da Silva
Summary: This study investigated the chemical characterization and antimicrobial properties of Ganoderma lucidum. The results showed that the methanolic extract of G. lucidum contained abundant phenolic and flavonoid compounds, exhibiting strong antioxidant and antimicrobial activities. These findings highlight the nutritional and medicinal significance of G. lucidum.
Article
Biochemistry & Molecular Biology
Da-Wei Li, Min Liu, Yue-Qi Leng, Jin-Fang Hu, Sa Deng, Ai-Jing Leng, Xiao-Chi Ma, Ruo-Yu Wang, Jian Zhou, Chao Wang
Summary: This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Article
Plant Sciences
Eva Sanchez-Hernandez, Ana Teixeira, Catarina Pereira, Adriana Cruz, Jesus Martin-Gil, Rui Oliveira, Pablo Martin-Ramos
Summary: This study investigated the chemical composition of an ammonia extract from Ganoderma lucidum and its potential as an antimicrobial. The extract contained several chemical compounds, and when conjugated with chitosan oligomers, it showed enhanced antimicrobial activity against plant pathogens. These findings suggest that the extract could be a valuable resource for protecting oak trees.
Article
Chemistry, Applied
Yang Zhao, Qinyang Li, Minghui Wang, Yuhua Wang, Chunhong Piao, Hansong Yu, Junmei Liu, Zhuowei Li
Summary: In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder, and two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) spore powder. The chemical structure and antioxidant activity of the polysaccharides were studied, and the effect of GLP and FGLP on the oxidative stress regulation pathway in HepG2 cells was explored.
Article
Biochemistry & Molecular Biology
Shanoo Suroowan, E. J. Llorent-Martinez, Gokhan Zengin, Asaad Khalid, Ashraf N. Abdalla, Soud Khogeer, Bao Van, Mohamad Fawzi Mahomoodally
Summary: This study investigated the phytochemical and pharmacological properties of Wikstroemia indica. The methanolic extract showed the highest content of phenolic compounds and exhibited the strongest antioxidant potential. The ethyl acetate extract and methanolic extract demonstrated good inhibitory activity against acetylcholinesterase, and the ethyl acetate extract also showed activity against butyrylcholinesterase. The tyrosinase and alpha amylase inhibitory potentials were confirmed, and the aqueous extract showed cytotoxicity against HT 29 cells.
PROCESS BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Tran Do Dat, Nguyen Duc Viet, Nguyen Minh Dat, Phan Le Thao My, Doan Ba Thinh, Lu Thi Mong Thy, Le Minh Huong, Pham Tan Khang, Nguyen Duy Hai, Hoang Minh Nam, Mai Thanh Phong, Nguyen Huu Hieu
Summary: This study successfully synthesized silver nanoparticles using Vietnamese Ganoderma lucidum extract, showing good crystallinity and nanoparticle stability. The synthesized silver nanoparticles exhibited excellent antimicrobial and antioxidant activities against various bacteria and fungi, and showed potential in anticancer applications as well.
SURFACES AND INTERFACES
(2021)
Article
Food Science & Technology
Ruobing Liu, Jing Gan, Mengdi Du, Xiao Kong, Chunxia Xu, Yue Lue, Shengliang Cao, Ting Meng, Bo Wang, Tianying Yu
Summary: In this study, chitosan, sodium alginate, and sodium tripolyphosphate were used to prepare hydrogels as a stable polypeptide delivery system. The prepared M-SCT hydrogels showed excellent pH sensitivity and loading capacity for Ganoderma lucidum peptides (GLP). The characterization and evaluation of the hydrogels were performed, confirming their internal network structure, electrostatic interactions among the components, and improved stability. The hydrogels also demonstrated efficient peptide release and retained the antioxidant activity of GLP, suggesting their potential as a carrier for oral delivery.
Review
Plant Sciences
Sze Wa Chan, Brian Tomlinson, Paul Chan, Christopher Wai Kei Lam
Summary: This review examines the effects of Ganoderma lucidum on major risk factors for cardiometabolic disease, showing potential benefits such as antioxidative, antihypertensive, hypoglycaemic, lipid-lowering, and anti-inflammatory properties in in vitro and in vivo studies. However, clinical trials have shown inconsistent results, indicating the need for further large controlled studies to clarify the potential health benefits of G. lucidum preparations standardized by known active components in the prevention and treatment of cardiometabolic disease.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Tanveer Hussain Bokhari, Shazia Bano, Muhammad Tanveer, Samreen Gul Khan, Saira Hina, Muhammad Idrees Jilani, Muhammad Latif, Sobhy M. Ibrahim, Munawar Iqbal, Arif Nazir
Summary: This study investigated the antimicrobial, antioxidant, biofilm activity, cytotoxicity, and mineral composition of the stem extracts of Halothamnus auriculus. The results showed high antimicrobial and antioxidant activity, as well as rich calcium content in the stem of H. auriculus.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2021)
Article
Biochemistry & Molecular Biology
Silvia Patruica, Ersilia Alexa, Diana Obistioiu, Ileana Cocan, Isidora Radulov, Adina Berbecea, Roxana Nicoleta Lazar, Eliza Simiz, Nicoleta Maria Vicar, Anca Hulea, Dragos Moraru
Summary: This paper presents the chemical characterization, antioxidant and antimicrobial potential of ten types of honey from the Banat region, Romania. The honey samples showed good nutritional characteristics and antimicrobial activity, and their antioxidant capacity varied depending on the type of honey.
Article
Chemistry, Applied
Dawei Li, Yueqi Leng, Zhengzheng Liao, Jinfang Hu, Yan Sun, Sa Deng, Chao Wang, Xiangge Tian, Jian Zhou, Ruoyu Wang
Summary: Two new nor-triterpenoids, ganodrenol A and B, and a new natural product, ganodrenol C, along with three known nor-triterpenoids, were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these compounds were determined by various analytical techniques. Compound 4 showed strong inhibition against FAAH, but exhibited no significant cytotoxicity.
NATURAL PRODUCT RESEARCH
(2023)
Review
Food Science & Technology
Xuhan Yang, Zhonglu Niu, Xiaorui Wang, Xiaoming Lu, Jinyue Sun, M. Carpena, M. A. Prieto, Jesus Simal-Gandara, Jianbo Xiao, Chao Liu, Ningyang Li
Summary: Pomegranate is a delicious fruit with beautiful flowers, rich in bioactive compounds that have benefits for human health. Different parts of the pomegranate contain distinct bioactive components, which possess antioxidant, anti-inflammatory, and anti-cancer properties, among others. It is widely used in various fields such as food, health care, and medicine.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Integrative & Complementary Medicine
Juliana Scanavacca, Wanessa de Campos Bortolucci, Ezilda Jacomassi, Irineia Paulina Baretta, Maria Graciela Iecher Faria, Carla Maria Mariano Fernandez, Vele Tesevic, Jasmina Glamoclija, Marina Sokovic, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study evaluated the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil. The essential oil showed broad antibacterial and antifungal activity, making it a potential alternative for microbial control.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Editorial Material
Chemistry, Applied
Maurizio Battino, Tarun Belwal, Miguel A. Prieto
Article
Chemistry, Applied
Angela Liberal, Daiana Almeida, Angela Fernandes, Carla Pereira, Isabel C. F. R. Ferreira, Ana Maria Vivar-Quintana, Lillian Barros
Summary: This study assessed the nutritional and chemical profiles, as well as the antioxidant capacity, of 34 Armun tilde a lentil samples. The results showed that lentils contain valuable nutrients such as carbohydrates, proteins, and ashes. The growing season had a significant impact on the major nutrients in lentils, while the soil type did not seem to affect any of the parameters analyzed.
Article
Engineering, Chemical
Carlos S. H. Shiraishi, Yosra Zbiss, Custodio Lobo Roriz, Maria Ines Dias, Miguel A. Prieto, Ricardo C. Calhelha, Maria Jose Alves, Sandrina A. Heleno, Vasco da Cunha Mendes, Marcio Carocho, Rui M. V. Abreu, Lillian Barros
Summary: The leaves of fig tree varieties BN and DA have shown good antioxidant, anticancer, and antimicrobial activities. Fig leaves can be regarded as sustainable sources of valuable bioactive molecules for various industrial applications.
Review
Agriculture, Dairy & Animal Science
Jessica Ribeiro, Vanessa Silva, Andreia Monteiro, Madalena Vieira-Pinto, Gilberto Igrejas, Filipa S. Reis, Lillian Barros, Patricia Poeta
Summary: Chicken meat is widely consumed around the world, and antibiotics have been used in its production to ensure high levels of output. However, the use of antibiotics in animal production has led to the emergence of antibiotic-resistant bacteria, particularly in the gut microbiota. Studies have found resistant strains of Enterococcus spp. and Escherichia coli in the gastrointestinal tract of chickens, with Enterococcus spp. showing resistance to at least seven classes of antibiotics and E. coli showing resistance to at least four. Some clonal lineages have also been identified in both broilers and humans, suggesting the transmission of bacteria through contaminated food, direct contact with animals, or environmental exposure.
Article
Food Science & Technology
Bianca R. Albuquerque, Maria Ines Dias, Jose Pinela, Ricardo C. Calhelha, Tania C. S. P. Pires, Maria Jose Alves, Rubia C. G. Correa, Isabel C. F. R. Ferreira, Maria Beatriz P. P. Oliveira, Lillian Barros
Summary: The ripe mangosteen pericarp contains seven organic acids, three tocopherol isomers, four fatty acids, and fifteen non-xanthone phenolic compounds. The most efficient extraction of phenolic compounds was achieved using hydroethanolic extract (MT80), followed by ethanolic extract (MTE), and then aqueous extract (MTW). Both MT80 and MTE extracts exhibited antioxidant and antibacterial activities. MTW did not show anti-inflammatory properties, while MTE and MT80 inhibited tumor cell lines.
Review
Infectious Diseases
Dejan Stojkovic, Jovana Petrovic, Tamara Carevic, Marina Sokovic, Konstantinos Liaras
Summary: This narrative review provides an overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in antibiotic-resistant strains. The review focuses on recent research and discusses a range of compounds that show promise in combating antibiotic resistance by targeting bacterial virulence factors. The findings suggest that further research is needed to identify and optimize new compounds with the potential to combat antibiotic-resistant bacterial infections.
Article
Materials Science, Multidisciplinary
Blessy Joseph, Amrit Jose John, Jasmina Glamoclija, Dejan Stojkovic, Marina Sokovic, Sasa Lazovic, Jayachandran Kochupurackal, Nandakumar Kalarikkal, Sabu Thomas
Summary: Electrospun fibers with large surface area are beneficial in tissue engineering due to their porous structure which promotes cell adhesion, proliferation, and migration. This study developed polycaprolactone (PCL) scaffolds incorporated with zirconium dioxide (ZrO2) nanoparticles using a simple approach. The scaffolds exhibited interconnected pore structure and the incorporation of nanoparticles was confirmed. Mechanical studies showed that 1 wt% Zirconium dioxide nanoparticles had the highest tensile strength. Furthermore, the scaffolds demonstrated antibacterial activity against Staphylococcus lugdunensis but not against Proteus vulgaris. These ZrO2 loaded PCL scaffolds with desirable properties have potential applications in tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Agriculture, Multidisciplinary
Angela Liberal, Daiana Almeida, Angela Fernandes, Carla Pereira, Isabel C. F. R. Ferreira, Ana Maria Vivar-Quintana, Lillian Barros
Summary: The aim of this study was to evaluate the nutritional profiles and antioxidant potential of different lentil varieties, as well as the impact of cultivation type (conventional or organic) and variety on these parameters. The results showed that all the varieties analyzed are an excellent source of fiber and have good antioxidant capacity. Lentil variety has a greater influence on its nutritional composition than the type of cultivation.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Multidisciplinary
Mirjana Peric, Aleksandra Cairovic, Aleksandra Spadijer Gostovic, Dragan Stanimirovic, Marina Kostic, Marija Ivanov, Ana Ciric, Jasmina Glamoclija, Vladimir B. Pavlovic
Summary: This study evaluated the surface texture and biofilm adhesion of veneered or CAD/CAM milled zirconia after professional oral hygiene procedures. The results showed that routine methods of oral hygiene professional maintenance can damage the surfaces of glazed zirconia restorations.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Edmilson Emanuel Monteiro Correia, Artur Figueirinha, Lisa Rodrigues, Jose Pinela, Ricardo C. Calhelha, Lillian Barros, Chantal Fernandes, Ligia Salgueiro, Teresa Goncalves
Summary: This study chemically characterized the ethanolic extract of Withania chevalieri and evaluated its bioactivities as antidermatophytic, antioxidant, anti-inflammatory and anticancer. The results demonstrated the potential of WcCEE as an effective treatment for skin fungal infections, with antioxidant, anti-inflammatory and anticancer activity.
Article
Biochemistry & Molecular Biology
Bianca R. Albuquerque, Tiane C. Finimundy, Jose Pinela, Tania C. S. P. Pires, Filipa Mandim, Josiana Vaz, Rubia C. G. Correa, Maria Beatriz P. P. Oliveira, Lillian Barros
Summary: This study aimed to determine the chemical composition and assess the bioactivities of the hydroethanolic extracts of different parts of Eugenia brasiliensis, a little explored Brazilian berry. The peel fraction showed the highest concentration of organic acids, vitamins, tannins, anthocyanins, and flavonoids, while the seed fraction had the highest content of monounsaturated fatty acids and hydrolysable tannins. The study also revealed that the residue of E. brasiliensis could serve as a good source of bioactive compounds, but further research is still needed to confirm its safety and understand the mechanisms behind its biological activities.
Article
Biochemistry & Molecular Biology
Joana Madureira, Bianca Albuquerque, Maria Ines Dias, Jose Pinela, Ricardo C. Calhelha, Celestino Santos-Buelga, Fernanda M. A. Margaca, Isabel C. F. R. Ferreira, Sandra Cabo Verde, Lillian Barros
Summary: Ultrasound-assisted extraction (UAE) was used to recover hydroxytyrosol and tyrosol from olive pomace. Optimization of the extraction process showed that UAE yielded higher amounts of both compounds compared to heat-assisted extraction (HAE). However, HAE extract exhibited greater bioactivity, including antioxidant, antidiabetic, anti-inflammatory, antibacterial, and cytotoxic effects, as well as no antifungal potential against C. albicans. These results provide valuable insights for the development of new bioactive ingredients in the food and pharmaceutical industries.
Article
Chemistry, Applied
Izamara de Oliveira, Antonios Chrysargyris, Tiane C. Finimundy, Marcio Carocho, Celestino Santos-Buelga, Ricardo C. Calhelha, Nikolaos Tzortzakis, Lillian Barros, Sandrina A. Heleno
Summary: In this study, pansy and viola edible flowers were grown hydroponically with varying levels of Mg and Mn. The effects of nutrient levels on plant growth and nutritional composition were investigated, and the chemical compounds and activities in the flowers were analyzed. The results showed that Mg enrichment had a negative impact on plant growth and mineral accumulation, but improved photosynthetic performance. The edible flowers contained significant amounts of protein, low levels of fat, and various sugar contents, and exhibited antioxidant, antimicrobial, cytotoxic, and anti-inflammatory properties. This research not only expands our understanding of Mg and Mn interaction, but also accelerates important advancements in sustainable agriculture and food health, promoting a healthier and more conscious future.
