Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Article
Medical Laboratory Technology
Maryam Tohidi, Samaneh Asgari, Abdolreza Chary, Fereidoun Azizi, Farzad Hadaegh
Summary: A study on low-risk individuals found that even within the normal range, LDL-C and non-HDL-C were still significantly associated with the risk of developing cardiovascular disease, independent of traditional risk factors.
CLINICAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Weiqiang Wu, Yanjuan Chen, Kuangyi Wu, Huancong Zheng, Guanzhi Chen, Xianxuan Wang, Zegui Huang, Zefeng Cai, Zhiwei Cai, Zhichao Chen, Yulong Lan, Shuohua Chen, Shouling Wu, Youren Chen
Summary: This study found that a high non-HDL-C concentration is associated with an increased risk of cardiovascular disease (CVD) in individuals with hypertension. Prolonged exposure to a high non-HDL-C concentration also increases the risk. Therefore, achieving target blood pressure and non-HDL-C concentrations can help reduce the risk of CVD in individuals with hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Immunology
Xiaoyu Pan, Xueqing Zhang, Jiangli Ban, Lin Yue, Lin Ren, Shuchun Chen
Summary: This study investigates the correlation of neutrophil count to HDL-C ratio (NHR) with cardiac ultrasound parameters and cardiovascular risk in healthy populations. The results show that participants in the high NHR group had significantly increased cardiac ultrasound parameters and cardiovascular risk compared to those in the low NHR group. Furthermore, the impact of NHR on cardiac ultrasound parameters and cardiovascular risk differs between males and females.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Parham Mardi, Fatemeh Abdi, Amir Ehsani, Ehsan Seif, Shirin Djalalinia, Javad Heshmati, Ehsan Shahrestanaki, Armita Mahdavi Gorabi, Mostafa Qorbani
Summary: This study examined the association between novel atherogenic lipid indices (including non-HDL-C, atherogenic index, and the difference between non-HDL-C and LDL-C) and metabolic syndrome (MetS) or its components. The results showed a strong correlation between these indices and increased odds of MetS and its components.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Jiahui Yan, Sisi Yang, Liang Han, Xin Ba, Pan Shen, Weiji Lin, Tingting Li, Ruiyuan Zhang, Ying Huang, Yao Huang, Kai Qin, Yu Wang, Shenghao Tu, Zhe Chen
Summary: This article describes the unique lipid profile of RA, explores the mechanisms underlying lipid changes, and investigates the impact of lipid changes on cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Vivencio Barrios, Xavier Pinto, Carlos Escobar, Jose F. F. Varona, Jose M. Gamez
Summary: Despite improvements in CVD prevention, a small proportion of patients achieve recommended LDL-C goals under high-intensity LLT. This study aimed to assess LDL-C target attainment and associated factors in a real-world setting in Spain. Of the 1570 patients included, the LDL-C goal attainment rate was 31.1%, with established CVD and familial hypercholesterolemia being significant factors for non-achievement.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Maria Pia Adorni, Nicoletta Ronda, Franco Bernini, Francesca Zimetti
Summary: HDL cholesterol efflux capacity (CEC) has emerged as a better predictor of cardiovascular risk compared to plasma HDL-cholesterol levels, and is often impaired in various genetic and pathological conditions associated with high cardiovascular risk.
Article
Nutrition & Dietetics
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Seung Hyeok Han, Soo Wan Kim
Summary: This study aimed to investigate the association between serum non-HDL-C levels and cardiovascular outcomes in non-dialysis chronic kidney disease patients. The study found that high serum non-HDL-C levels were associated with an increased risk of adverse cardiovascular outcomes, and this association was not affected by clinical factors such as age, gender, body mass index, estimated glomerular filtration rate, and albuminuria.
Review
Biochemistry & Molecular Biology
Harold Superko, Brenda Garrett
Summary: Despite statin use and LDL-C reduction, residual cardiovascular disease event risk remains. Abnormal lipoprotein size and density distribution, known as lipoprotein heterogeneity, contributes to this residual risk. Recent clinical trial evidence reinforces the importance of LDL heterogeneity measurement and its impact on CHD risk prediction and outcomes.
Article
Nutrition & Dietetics
Rebeca Quiros-Fernandez, Bricia Lopez-Plaza, Laura M. Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gomez Candela
Summary: The supplement containing HT and PC showed significant improvement in dyslipidemia, indicating its potential for preventing atherosclerosis and protecting the heart in adults.
Article
Medicine, General & Internal
In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
Summary: The study found that the risk of MACE incidence decreased in statin users, but increased for low-risk statin users, with no significant relationship identified for intermediate and borderline risk groups. The risk of MACE incidence decreased only in the high CVD risk group among statin users.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xin Su, Deqiang Zheng, Meiping Wang, Yingting Zuo, Jing Wen, Qi Zhai, Yibo Zhang, Yan He
Summary: This study aimed to evaluate the relationship between elevated low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD) risk in a contemporary population aged over 70 years in China. The results showed that elevated LDL-C levels increased the risk of CVD in participants over 70 years old, and a lower level of LDL-C did not increase CVD risk in the left side of the U-shaped curve.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
