Editorial Material
Genetics & Heredity
Ivona Aksentijevich
Summary: Immune responses require a delicate balance - too weak or too strong a response can cause issues. Spleen tyrosine kinase plays a crucial role in multiple signaling pathways, and its gain-of-function alterations can lead to various problems, including hypogammaglobulinemia and predisposition to B cell lymphoma.
Review
Biochemistry & Molecular Biology
Zhi Yang, Shigao Huang, Lina Zhao
Summary: This review summarizes the mechanisms of SOCS6 regulation in multiple pathways, focusing on its inhibitory role in cancer progression. Additionally, the clinical relevance of SOCS6 in cancer biomarkers and prognosis, as well as its significance in chemoresistance and radioresistance, are discussed.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones
Summary: Glioblastoma multiforme (GBM) is a deadly cancer with limited response to existing therapies. Subtypes of GBM with distinct genetic signatures show aberrant activation of signal transduction pathways. Current research focuses on understanding these molecular alterations to develop more efficient targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huynh Cao, Verena Tadros, Benjamin Hiramoto, Kevin Leeper, Christopher Hino, Jeffrey Xiao, Bryan Pham, Do Hyun Kim, Mark E. Reeves, Chien-Shing Chen, Jiang F. Zhong, Ke K. Zhang, Linglin Xie, Samiksha Wasnik, David J. Baylink, Yi Xu
Summary: In this study, the researchers investigated the therapeutic targets responsible for the survival and proliferation of FLT3 mutated acute myeloid leukemia (AML) cells after treatment with the tyrosine kinase inhibitor gilteritinib (GILT). They found that macrophage migration inhibition factor (MIF) was significantly increased in treated cells and that these cells also exhibited higher expressions of the CXCR2 gene and protein, which is a receptor for MIF and pro-inflammatory cytokines. Additionally, the researchers identified the NFKB2 pathway as highly activated after GILT treatment. Knockdown of NFKB2 significantly reduced the gene expressions of MIF, CXCR2, and CXCL5. The combination of a pharmaceutical inhibitor of the NFKB family and GILT effectively suppressed primary AML cells' secretion of tumor-promoting cytokines.
Article
Multidisciplinary Sciences
Christian C. D. Harman, Will Bailis, Jun Zhao, Louisa Hill, Rihao Qu, Ruaidhri P. Jackson, Justin A. Shyer, Holly R. Steach, Yuval Kluger, Loyal A. Goff, John L. Rinn, Adam Williams, Jorge Henao-Mejia, Richard A. Flavell
Summary: The research reveals that a noncoding element regulates the broadly expressed transcription factor Ikaros in a lymphoid lineage-specific manner, impacting the number of lymphoid progenitors and participating in lymphoid fate determination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Kay L. Medina
Summary: The Class III receptor tyrosine kinase Flt3 and its ligand, the Flt3-ligand, play important roles in regulating hematopoietic and lymphoid progenitor cell proliferation, differentiation, and survival. They have also been found to be crucial in peripheral B cell development and affinity maturation. This review provides a comprehensive understanding of the molecular and cellular regulation of Flt3/FL and the roles of Flt3 signaling in hematopoietic stem cell activation, lymphoid development, bone marrow B lymphopoiesis, and peripheral B cell development. The literature confirms the significance of Flt3 signaling in B cell development and function, but also highlights the need for further research on Flt3-dependent stage-specific gene regulatory circuits in steady-state B lymphopoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Sareshma Sudhesh Dev, Syafiq Asnawi Zainal Abidin, Reyhaneh Farghadani, Iekhsan Othman, Rakesh Naidu
Summary: Receptor tyrosine kinases (RTKs) are crucial cell-surface proteins that regulate essential cellular processes, with alterations in them playing a key role in cancer progression. Curcumin, as an attractive anti-cancer agent, exhibits potent effects by inhibiting RTKs and downstream signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Payam E. Farahani, Xiaoyu Yang, Emily Mesev, Kaylan A. Fomby, Ellen H. Brumbaugh-Reed, Caleb J. Bashor, Celeste M. Nelson, Jared E. Toettcher
Summary: pYtags is a modular approach for monitoring the activity of a specific RTK by live-cell microscopy. It enables monitoring of a specific RTK on different time and space scales with high specificity. Using pYtag biosensors, signaling dynamics can be quantitatively characterized with different activating ligands. The specificity and modularity of pYtags open the door to robust biosensors of multiple tyrosine kinases.
Article
Medicine, Research & Experimental
Sylvain Carras, Dimitri Chartoire, Sylvain Mareschal, Mael Heiblig, Antoine Marcais, Remy Robinot, Mirjam Urb, Roxane M. Pommier, Edith Julia, Amel Chebel, Aurelie Verney, Charlotte Bertheau, Emilie Bardel, Caroline Fezelot, Lucien Courtois, Camille Lours, Alyssa Bouska, Sunandini Sharma, Christine Lefebvre, Jean-Pierre Rouault, David Sibon, Anthony Ferrari, Javeed Iqbal, Laurence de Leval, Philippe Gaulard, Alexandra Traverse-Glehen, Pierre Sujobert, Mathieu Blery, Gilles Salles, Thierry Walzer, Emmanuel Bachy, Laurent Genestier
Summary: Chronic TCR stimulation may drive T cell lymphomagenesis, but does not affect PTCL cell survival. NK cell-like reprogramming may occur in PTCL cells, with expression of NK receptors and downstream signaling molecules.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Amy L. Whillock, Tiffany K. Ybarra, Gail A. Bishop
Summary: TRAF3 has diverse signaling functions, inhibiting homeostatic survival in B lymphocytes, while enhancing T-cell effector functions. It plays a role in inhibiting noncanonical NF-kappa B activation, CD40 and BAFF-R signaling in B cells, and its absence promotes abnormal survival of malignant B cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Himangshu Sonowal, William G. Rice, Stephen B. Howell
Summary: Luxeptinib (LUX) is a novel oral kinase inhibitor that targets multiple signaling pathways and has shown promising activity in lymphoma and AML patients.
Article
Hematology
Roger Belizaire, Sebastian H. J. Koochaki, Namrata D. Udeshi, Alexis Vedder, Lei Sun, Tanya Svinkina, Christina Hartigan, Marie McConkey, Veronica Kovalcik, Amanuel Bizuayehu, Caroline Stanclift, Monica Schenone, Steven A. Carr, Eric Padron, Benjamin L. Ebert
Summary: Mutations in CBL affect cellular signaling, leading to aberrant activation of the CBL-PI3K/AKT pathway and promoting cell proliferation. Activation of LYN and its interaction with mutated CBL are key drivers in this process. Inhibiting LYN can reduce CBL phosphorylation and decrease the activity of the PI3K/AKT signaling pathway.
Article
Cell Biology
Juanjuan Xiao, Lu Zhang, Huijun Yi, Ling Zou, Jianmei Mo, Feng Xue, Jinhua Zheng, Yingze Huang, Hui Lu, Hansheng Wu, Peipei Xue, Xin Zhang, Lifei He, Zhaoxin Li, Shigui Pang, Guibin Qiao, Qiuhong Duan, Feng Zhu
Summary: This study reveals the role of T-LAK cell-oriented protein kinase (TOPK) in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). The researchers found that TOPK is highly expressed in ALK-positive NSCLC and identified ALK as an upstream kinase of TOPK. Moreover, they showed that inhibiting TOPK enhances tumor sensitivity to an ALK inhibitor, and the combination of alectinib and a TOPK inhibitor suppresses tumor growth and promotes apoptosis of ALK-positive NSCLC cells.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Thomas Chabot, Yvonnick Cheraud, Fabrice Fleury
Summary: Receptor Tyrosine Kinases (RTKs) play a crucial role in cancer cell survival and are relevant targets in cancer research. Recent studies have shown a close relationship between RTK signaling and DNA repair regulation, providing new research directions for the development of therapeutic strategies targeting both pathways.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Cell Biology
Pardis Mohammadzadeh, Mina Roueinfar, Gregory C. Amberg
Summary: This study reveals a novel role for AXL as a modulator of GnRH receptor signaling. Gas6 enhances GnRH-dependent ERK phosphorylation and Egr-1 transcript abundance, and promotes LH beta production and pro-MMP9 protein generation, as well as cell migration.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Francois Dossin, Ines Pinheiro, Jan J. Zylicz, Julia Roensch, Samuel Collombet, Agnes Le Saux, Tomasz Chelmicki, Mikael Attia, Varun Kapoor, Ye Zhan, Florent Dingli, Damarys Loew, Thomas Mercher, Job Dekker, Edith Heard
Article
Hematology
Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Pique-Borras, Cathy Ignacimouttou, Alexis Caulier, Cecile K. Lopez, Elie Robert, Benjamin Uzan, Veronique Gelsi-Boyer, Zakia Aid, Cecile Thirant, Ute Moll, Samantha Tauchmann, Amina Kurtovic-Kozaric, Jaroslaw Maciejewski, Christine Dierks, Orietta Spinelli, Silvia Salmoiraghi, Thomas Pabst, Kazuya Shimoda, Virginie Deleuze, Helene Lapillonne, Connor Sweeney, Veronique De Mas, Betty Leite, Zahra Kadri, Sebastien Malinge, Stephane de Botton, Jean-Baptiste Micol, Benjamin Kile, Catherine L. Carmichael, Ilaria Iacobucci, Charles G. Mullighan, Martin Carroll, Peter Valent, Olivier A. Bernard, Eric Delabesse, Paresh Vyas, Daniel Birnbaum, Eduardo Anguita, Loic Garcon, Eric Soler, Juerg Schwaller, Thomas Mercher
Article
Oncology
Anouchka P. Laurent, Aurelie Siret, Cathy Ignacimouttou, Kunjal Panchal, M'Boyba Diop, Silvia Jenni, Yi-Chien Tsai, Damien Roos-Weil, Zakia Aid, Nais Prade, Stephanie Lagarde, Damien Plassard, Gaelle Pierron, Estelle Daudigeos, Yann Lecluse, Nathalie Droin, Beat C. Bornhauser, Laurence C. Cheung, John D. Crispino, Muriel Gaudry, Olivier A. Bernard, Elizabeth Macintyre, Carole Barin Bonnigal, Rishi S. Kotecha, Birgit Geoerger, Paola Ballerini, Jean-Pierre Bourquin, Eric Delabesse, Thomas Mercher, Sebastien Malinge
CLINICAL CANCER RESEARCH
(2020)
Meeting Abstract
Hematology
Samantha Tauchmann, Frederik Otzen Bagger, Thomas Bock, Roos Krimpenfort, Francesca Aglialoro, Peter Valent, Alexandre Fagnan, Marieke von Lindern, Thomas Mercher, Juerg Schwaller
Article
Biochemistry & Molecular Biology
Loelia Babin, Alice Darchen, Elie Robert, Zakia Aid, Rosalie Borry, Claire Soudais, Marion Piganeau, Anne De Cian, Carine Giovannangeli, Olivia Bawa, Charlotte Rigaud, Jean-Yves Scoazec, Lucile Couronne, Layla Veleanu, Agata Cieslak, Vahid Asnafi, David Sibon, Laurence Lamant, Fabienne Meggetto, Thomas Mercher, Erika Brunet
Summary: This study generated a model of ALK+ ALCL lymphomagenesis by editing the NPM-ALK fusion gene in mature T lymphocytes, and identified the activation of the WNT signaling pathway and the expression of ROR2 as potential therapeutic targets for ALK+ ALCL.
Article
Oncology
Jhajaira M. Araujo, Gabriel De la Cruz-Ku, Melanie Cornejo, Franco Doimi, Richard Dyer, Henry L. Gomez, Joseph A. Pinto
Summary: This study evaluated the prognostic capability of a 3-gene score in different subtypes of triple negative breast cancer (TNBC). The results showed that the score was able to predict the risk of distant recurrence in the immunomodulatory and mesenchymal stem-like subtypes. Additionally, a low score was associated with a high level of tumor-infiltrating lymphocytes.
Editorial Material
Hematology
Cecile K. Lopez, Thomas Mercher
Summary: In this study, the authors used human and murine models to identify genes that are crucial for the survival of ecotropic virus integration site-1 (EVI1)-driven acute myeloid leukemia (AML) cells. They found that ERG is a conserved direct transcriptional target of EVI1, which plays a critical role in promoting cell survival and blocking differentiation in AML cells.
Article
Oncology
Zakia Aid, Elie Robert, Cecile K. Lopez, Maxence Bourgoin, Fabien Boudia, Melchior Le Mene, Julie Riviere, Marie Baille, Salima Benbarche, Laurent Renou, Alexandre Fagnan, Cecile Thirant, Laetitia Federici, Laure Touchard, Yann Lecluse, Anton Jetten, Birgit Geoerger, Helene Lapillonne, Eric Solary, Muriel Gaudry, Soheil Meshinchi, Francoise Pflumio, Patrick Auberger, Camille Lobry, Arnaud Petit, Arnaud Jacquel, Thomas Mercher
Summary: Pediatric acute myeloid leukemia expressing the ETO2::GLIS2 fusion oncogene has a poor prognosis. The expression of ETO2::GLIS2 leads to activation of CASP3 and increased cell death. Inhibiting both BCL2 and MCL1 is necessary to prevent disease progression in vivo, suggesting a potential therapeutic strategy for this aggressive pediatric AML subgroup.
Meeting Abstract
Medicine, General & Internal
Z. Jevtic, M. R. Pique-Borras, F. Otzen Bagger, J. Seguin, M. Filgueira Bezerra, A. Louwagie, S. Juge, I. Nellas, R. Ivanek, A. Tzankov, U. M. Moll, O. Cantillo, R. Schulz-Heddergott, A. Fagnan, T. Mercher, J. Schwaller
SWISS MEDICAL WEEKLY
(2022)
Article
Medicine, Research & Experimental
Brahim Arkoun, Elie Robert, Fabien Boudia, Stefania Mazzi, Virginie Dufour, Aurelie Siret, Yasmine Mammasse, Zakia Aid, Matthieu Vieira, Imanci Aygun, Marine Aglave, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gerard Tachdjian, Olivier Hermine, Nathalie Droin, Najet Debili, Isabelle Plo, Sebastien Malinge, Eric Soler, Hana Raslova, Thomas Mercher, William Vainchenker
Summary: This study models the clonal evolution of Down syndrome acute megakaryoblastic leukemia (DS-AMKL) and reveals the roles of different mutations in differentiation blockage. The findings demonstrate the significant impact of GATA1s, SMC3, MPL, and T21 mutations on megakaryocyte differentiation and leukemic progression.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Pediatrics
S. Tauchmann, F. O. Bagger, T. Bock, R. Sivalingam, T. Eder, A. Fagnan, M. von Lindern, T. Mercher, F. Grebien, J. Schwaller
KLINISCHE PADIATRIE
(2022)
Article
Multidisciplinary Sciences
Salima Benbarche, Cecile K. Lopez, Eralda Salataj, Zakia Aid, Cecile Thirant, Marie-Charlotte Laiguillon, Severine Lecourt, Yannis Belloucif, Camille Vaganay, Marion Antonini, Jiang Hu, Alexandra da Silva Babinet, Delphine Ndiaye-Lobry, Bryann Pardieu, Arnaud Petit, Alexandre Puissant, Julie Chaumeil, Thomas Mercher, Camille Lobry
Summary: This study reveals that fusion oncogenes like ETO2-GLIS2 can induce the activation of Super Enhancers (SEs) that regulate essential gene modules synergizing for leukemia progression, promoting the growth and survival of leukemia cells.
Meeting Abstract
Hematology
Thomas Mercher
EXPERIMENTAL HEMATOLOGY
(2021)
Letter
Hematology
Elia Henry, Vilma Barroca, Cecile K. Lopez, Michel Aurrand-Lions, Daniel Lewandowski, Thomas Mercher, Marie-Laure Arcangeli
Review
Hematology
Alexandre Fagnan, Maria-Riera Pique-Borras, Samantha Tauchmann, Thomas Mercher, Juerg Schwaller
Summary: Research on human erythroleukemia genetics combined with findings from various mouse models suggests that the pathogenesis of the disease is based on the interplay between signaling mutations, impaired TP53 function, and altered chromatin organization. These alterations result in aberrant activity of erythroid transcriptional master regulators like GATA1, indicating that treating erythroleukemia will most likely require combinatorial targeting.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
