The sickening consequences of too much SYK signaling

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

(2021) Lin Wang et al.   NATURE GENETICS

Fostamatinib: a review of its clinical efficacy and safety in the management of chronic adult immune thrombocytopenia

(2020) Adrian Newland et al.   Immunotherapy

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice

(2019) Dániel Csete et al.   Frontiers in Immunology

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer

(2015) Mariya O. Krisenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

(2013) Linfeng Chen et al.   CANCER CELL

Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling

(2013) Alexandros P. Grammatikos et al.   PLoS One

Markers of B-Cell Activation in Relation to Risk of Non-Hodgkin Lymphoma

(2012) A. J. De Roos et al.   CANCER RESEARCH

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

B lymphocytes: how they develop and function

(2008) T. W. LeBien et al.   BLOOD