Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy

Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2

(2013) Y A Aldhamen et al.   CANCER GENE THERAPY

Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen

(2013) Charles F. Aylsworth et al.   HUMAN IMMUNOLOGY

CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes

(2013) Jong R. Kim et al.   INFLAMMATION RESEARCH

Subversion of Phagocytosis for Pathogen Survival

(2012) Helen Sarantis et al.   Cell Host & Microbe

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

Adjuvants for human vaccines

(2012) Carl R Alving et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammatory Monocytes Activate Memory CD8+ T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion

(2012) Saïdi M'Homa Soudja et al.   IMMUNITY

Vaccines Expressing the Innate Immune Modulator EAT-2 Elicit Potent Effector Memory T Lymphocyte Responses despite Pre-Existing Vaccine Immunity

(2012) Y. A. Aldhamen et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Merck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity

(2012) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Use of DAF-Displaying Adenovirus Vectors Reduces Induction of Transgene- and Vector-Specific Adaptive Immune Responses in Mice

(2011) Sergey S. Seregin et al.   HUMAN GENE THERAPY

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Innate immunity and adjuvants

(2011) S. Akira   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Vaccine Platforms Combining Circumsporozoite Protein and Potent Immune Modulators, rEA or EAT-2, Paradoxically Result in Opposing Immune Responses

(2011) Nathaniel J. Schuldt et al.   PLoS One

Immune Recognition of Gene Transfer Vectors: Focus on Adenovirus as a Paradigm

(2011) Yasser Ali Aldhamen et al.   Frontiers in Immunology

The role of SAP and SLAM family molecules in the humoral immune response

(2010) Cindy S. Ma et al.   Annals of the New York Academy of Sciences

Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo

(2010) S. S. Seregin et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Cutting Edge: The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse

(2010) N. Wang et al.   JOURNAL OF IMMUNOLOGY

Expression of the SLAM Family of Receptors Adapter EAT-2 as a Novel Strategy for Enhancing Beneficial Immune Responses to Vaccine Antigens

(2010) Y. A. Aldhamen et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors

(2010) A. Veillette   Cold Spring Harbor Perspectives in Biology

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Importance and mechanism of ‘switch’ function of SAP family adapters

(2009) André Veillette et al.   IMMUNOLOGICAL REVIEWS

Inhibition and Activation by CD244 Depends on CD2 and Phospholipase C-γ1

(2009) Nicholas G. Clarkson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN

(2009) W. C. Adams et al.   JOURNAL OF GENERAL VIROLOGY

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

(2009) Zhongjun Dong et al.   NATURE IMMUNOLOGY

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

(2009) Mario-Ernesto Cruz-Munoz et al.   NATURE IMMUNOLOGY

Modulation of adaptive immunity with Toll-like receptors

(2009) Santhakumar Manicassamy et al.   SEMINARS IN IMMUNOLOGY

Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors

(2008) J M. Blander   ANNALS OF THE RHEUMATIC DISEASES

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections

(2008) Sang-Jun Ha et al.   IMMUNOLOGICAL REVIEWS

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE