SLAM Family Receptors and SAP Adaptors in Immunity

Impaired SLAM-SLAM Homotypic Interaction between Invariant NKT Cells and Dendritic Cells Affects Differentiation of IL-4/IL-10-Secreting NKT2 Cells in Nonobese Diabetic Mice

(2014) D. V. Baev et al.   JOURNAL OF IMMUNOLOGY

Normal Development and Activation but Altered Cytokine Production of Fyn-Deficient CD4+ T Cells

(2014) A. A. Mamchak et al.   JOURNAL OF IMMUNOLOGY

SAP Enables T Cells to Help B Cells by a Mechanism Distinct from Th Cell Programming or CD40 Ligand Regulation

(2014) C. Kamperschroer et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis of the Dual Functions of 2B4 (CD244)

(2014) L. K. Chlewicki et al.   JOURNAL OF IMMUNOLOGY

Differential Requirement for the SAP-Fyn Interaction during NK T Cell Development and Function

(2014) S. Nunez-Cruz et al.   JOURNAL OF IMMUNOLOGY

A Novel ICOS-Independent, but CD28- and SAP-Dependent, Pathway of T Cell-Dependent, Polysaccharide-Specific Humoral Immunity in Response to Intact Streptococcus pneumoniae versus Pneumococcal Conjugate Vaccine

(2014) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

The Adaptor Molecule Signaling Lymphocytic Activation Molecule-Associated Protein (SAP) Regulates IFN-  and IL-4 Production in V 14 Transgenic NKT Cells via Effects on GATA-3 and T-bet Expression

(2014) O. Cen et al.   JOURNAL OF IMMUNOLOGY

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

(2010) A. D. Hislop et al.   BLOOD

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

(2010) R. A. Marsh et al.   BLOOD

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

(2010) C. Booth et al.   BLOOD

Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus

(2010) J. R. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

(2010) Jennifer L. Cannons et al.   IMMUNITY

SAP Protein-Dependent Natural Killer T-like Cells Regulate the Development of CD8+ T Cells with Innate Lymphocyte Characteristics

(2010) Mihalis Verykokakis et al.   IMMUNITY

Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl Ubiquitin Ligase

(2010) Hun Sik Kim et al.   IMMUNITY

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

Absence of mouse 2B4 promotes NK cell–mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis

(2010) Stephen N. Waggoner et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse

(2010) N. Wang et al.   JOURNAL OF IMMUNOLOGY

Biochemical and Genetic Evidence for a SAP-PKC-  Interaction Contributing to IL-4 Regulation

(2010) J. L. Cannons et al.   JOURNAL OF IMMUNOLOGY

Slam Haplotypes Modulate the Response to Lipopolysaccharide In Vivo through Control of NKT Cell Number and Function

(2010) I. Aktan et al.   JOURNAL OF IMMUNOLOGY

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

PLZF Induces the Spontaneous Acquisition of Memory/Effector Functions in T Cells Independently of NKT Cell-Related Signals

(2010) D. Kovalovsky et al.   JOURNAL OF IMMUNOLOGY

Mouse CD84 is a pan -leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages

(2010) Jordi Sintes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages

(2010) Scott B Berger et al.   NATURE IMMUNOLOGY

The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage

(2010) Taishan Hu et al.   NATURE IMMUNOLOGY

Control systems and decision making for antibody production

(2010) Christopher C Goodnow et al.   NATURE IMMUNOLOGY

T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells

(2010) Michael A Weinreich et al.   NATURE IMMUNOLOGY

Inhibitor of DNA Binding 3 Limits Development of Murine Slam-Associated Adaptor Protein-Dependent “Innate” γδ T cells

(2010) Mihalis Verykokakis et al.   PLoS One

Increased lymphocyte viability after non-stimulated peripheral blood mononuclear cell (PBMC) culture in patients with X-linked lymphoproliferative disease (XLP)

(2009) Liliana Belmonte et al.   CLINICAL IMMUNOLOGY

Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populations

(2009) Rebecca A. Marsh et al.   CLINICAL IMMUNOLOGY

Lineage specification and heterogeneity of T follicular helper cells

(2009) Di Yu et al.   CURRENT OPINION IN IMMUNOLOGY

Functional role of human NK cell receptor 2B4 (CD244) isoforms

(2009) Stephen O. Mathew et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly

(2009) M. Zhao et al.   HAEMATOLOGICA

Marked Induction of the Helix-Loop-Helix Protein Id3 Promotes the γδ T Cell Fate and Renders Their Functional Maturation Notch Independent

(2009) Jens Peter Holst Lauritsen et al.   IMMUNITY

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses

(2009) Dongfang Liu et al.   IMMUNITY

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH ) cell lineage is induced by IL-12

(2009) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibition and Activation by CD244 Depends on CD2 and Phospholipase C-γ1

(2009) Nicholas G. Clarkson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of PLZF+CD4+T cells via MHC class II–dependent thymocyte–thymocyte interaction is a physiological process in humans

(2009) You Jeong Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate    T Cells Is Controlled by Strength of TCR Signaling and Id3

(2009) E. S. Alonzo et al.   JOURNAL OF IMMUNOLOGY

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

(2009) Zhongjun Dong et al.   NATURE IMMUNOLOGY

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

(2009) Mario-Ernesto Cruz-Munoz et al.   NATURE IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Tec kinase Itk in   T cells is pivotal for controlling IgE production in vivo

(2009) M. Felices et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease

(2009) N. Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of    T cells with restricted TCR diversity

(2009) T. Kreslavsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux

(2008) Elena A. Ostrakhovitch et al.   CELLULAR SIGNALLING

The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation

(2008) C LI et al.   CELLULAR SIGNALLING

Yaaautoimmune phenotypes are conferred by overexpression of TLR7

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association of LY9 in UK and Canadian SLE families

(2008) D S Cunninghame Graham et al.   GENES AND IMMUNITY

Inhibitory Receptor Signaling via Tyrosine Phosphorylation of the Adaptor Crk

(2008) Mary E. Peterson et al.   IMMUNITY

Complementation In Trans of Altered Thymocyte Development in Mice Expressing Mutant Forms of the Adaptor Molecule SLP76

(2008) Martha S. Jordan et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY

Antigen-specific responses and ANA production in B6.Sle1b mice: A role for SAP

(2008) Paula Jennings et al.   JOURNAL OF AUTOIMMUNITY

Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity

(2008) Ming-Chao Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms

(2008) Ifigenia Saborit-Villarroya et al.   MOLECULAR IMMUNOLOGY

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

(2008) Akari Suzuki et al.   NATURE GENETICS

The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

(2008) Damian Kovalovsky et al.   NATURE IMMUNOLOGY

SAP expression in T cells, not in B cells, is required for humoral immunity

(2008) A. Veillette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP

(2007) Stefan Mehrle et al.   MOLECULAR IMMUNOLOGY