Merck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity
出版年份 2012 全文链接
标题
Merck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 50, Pages E3503-E3512
出版商
Proceedings of the National Academy of Sciences
发表日期
2012-11-15
DOI
10.1073/pnas.1208972109
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Optimization and qualification of a multiplex bead array to assess cytokine and chemokine production by vaccine-specific cells
- (2012) Olivier D. Defawe et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Host Immune Transcriptional Profiles Reflect the Variability in Clinical Disease Manifestations in Patients with Staphylococcus aureus Infections
- (2012) Romain Banchereau et al. PLoS One
- Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
- (2011) Wenjun Ouyang et al. Annual Review of Immunology
- Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes
- (2011) Lihua Shi et al. GENE
- Impact of Herpes Simplex Virus Type 2 on HIV-1 Acquisition and Progression in an HIV Vaccine Trial (the Step Study)
- (2011) Ruanne V Barnabas et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Krüppel-like factor 4 regulates macrophage polarization
- (2011) Xudong Liao et al. JOURNAL OF CLINICAL INVESTIGATION
- Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine
- (2011) Nicole Frahm et al. JOURNAL OF CLINICAL INVESTIGATION
- Low-Dose Penile SIVmac251 Exposure of Rhesus Macaques Infected with Adenovirus Type 5 (Ad5) and Then Immunized with a Replication-Defective Ad5-Based SIV gag/pol/nef Vaccine Recapitulates the Results of the Phase IIb Step Trial of a Similar HIV-1 Vaccine
- (2011) H. Qureshi et al. JOURNAL OF VIROLOGY
- Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study
- (2011) Glenda E Gray et al. LANCET INFECTIOUS DISEASES
- A 2020 vision for vaccines against HIV, tuberculosis and malaria
- (2011) Rino Rappuoli et al. NATURE
- Systems biology of vaccination for seasonal influenza in humans
- (2011) Helder I Nakaya et al. NATURE IMMUNOLOGY
- Immunological mechanisms of vaccination
- (2011) Bali Pulendran et al. NATURE IMMUNOLOGY
- CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates
- (2011) Nancy J Sullivan et al. NATURE MEDICINE
- Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
- (2011) Morgane Rolland et al. NATURE MEDICINE
- Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
- (2011) D. E. Zak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overcoming limitations in the systems vaccinology approach
- (2011) Daniel E. Zak et al. Current Opinion in HIV and AIDS
- Profiling immunity to HIV vaccines with systems biology
- (2011) Erica Andersen-Nissen et al. Current Opinion in HIV and AIDS
- Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case–control study
- (2010) Marcel E Curlin et al. AIDS
- Suppression of HIV Replication by Antiretroviral Therapy Reduces TIM-3 Expression on HIV-Specific CD8+ T Cells
- (2010) Afework Kassu et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Cutting Edge: The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse
- (2010) N. Wang et al. JOURNAL OF IMMUNOLOGY
- Expression of the SLAM Family of Receptors Adapter EAT-2 as a Novel Strategy for Enhancing Beneficial Immune Responses to Vaccine Antigens
- (2010) Y. A. Aldhamen et al. JOURNAL OF IMMUNOLOGY
- Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo
- (2010) N. A. Jewell et al. JOURNAL OF VIROLOGY
- An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
- (2010) Matthew P. R. Berry et al. NATURE
- Evaluation of yellow fever virus 17D strain as a new vector for HIV-1 vaccine development
- (2010) David Franco et al. VACCINE
- Immunization With a Bivalent Adenovirus-vectored Tuberculosis Vaccine Provides Markedly Improved Protection Over Its Monovalent Counterpart Against Pulmonary Tuberculosis
- (2009) Jingyu Mu et al. MOLECULAR THERAPY
- Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals
- (2009) Vladimir Litvak et al. NATURE IMMUNOLOGY
- Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
- (2009) Mario-Ernesto Cruz-Munoz et al. NATURE IMMUNOLOGY
- Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans
- (2009) Kara L O'Brien et al. NATURE MEDICINE
- Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells
- (2009) Natalie A Hutnick et al. NATURE MEDICINE
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
- (2009) Supachai Rerks-Ngarm et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1
- (2009) A. Benlahrech et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Post-Step modifications for research on HIV vaccines
- (2008) Lawrence Corey et al. AIDS
- Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
- (2008) Xi Chen et al. CELL
- A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
- (2008) Damien Chaussabel et al. IMMUNITY
- Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL
- (2008) Zuopeng Wu et al. IMMUNITY
- Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells
- (2008) Matthieu Perreau et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
- (2008) Denis Gaucher et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Biodistribution and Toxicological Safety of Adenovirus Type 5 and Type 35 Vectored Vaccines Against Human Immunodeficiency Virus-1 (HIV-1), Ebola, or Marburg Are Similar Despite Differing Adenovirus Serotype Vector, Manufacturer's Construct, or Gene Inserts
- (2008) Rebecca L. Sheets et al. Journal of Immunotoxicology
- HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis
- (2008) M Juliana McElrath et al. LANCET
- Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
- (2008) Susan P Buchbinder et al. LANCET
- InnateDB: facilitating systems-level analyses of the mammalian innate immune response
- (2008) David J Lynn et al. Molecular Systems Biology
- Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression
- (2008) Wei Liao et al. NATURE IMMUNOLOGY
- Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
- (2008) Troy D Querec et al. NATURE IMMUNOLOGY
- Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics
- (2008) Stephen A. Ramsey et al. PLoS Computational Biology
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