Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity

Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF

(2014) W. Xu et al.   JOURNAL OF IMMUNOLOGY

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

(2010) Meng Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia

(2009) Lars Klemm et al.   CANCER CELL

The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription

(2009) Hong Ming Shen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen directly activates AID transcription and function

(2009) Siim Pauklin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation-Induced Cytidine Deaminase Expression and Activity in the Absence of Germinal Centers: Insights into Hyper-IgM Syndrome

(2009) M. Kuraoka et al.   JOURNAL OF IMMUNOLOGY

Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR–ABL1-positive acute lymphoblastic leukemia patients

(2009) I Iacobucci et al.   LEUKEMIA

AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations

(2009) Mona Leuenberger et al.   MODERN PATHOLOGY

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

Mechanisms promoting translocations in editing and switching peripheral B cells

(2009) Jing H. Wang et al.   NATURE

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

(2009) Nidhi Bhutani et al.   NATURE

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

(2009) Seok-Rae Park et al.   NATURE IMMUNOLOGY

B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

(2009) Thinh Huy Tran et al.   NATURE IMMUNOLOGY

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

(2009) Maki Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

(2009) Hwei-Ling Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

(2009) Tomomitsu Doi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

(2008) Grace Teng et al.   IMMUNITY

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY

Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion

(2008) H. Kitao et al.   INTERNATIONAL IMMUNOLOGY

Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression

(2008) Toshiyuki Morisawa et al.   INTERNATIONAL JOURNAL OF CANCER

Impact of Phosphorylation and Phosphorylation-null Mutants on the Activity and Deamination Specificity of Activation-induced Cytidine Deaminase

(2008) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites

(2008) Albert G. Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AID expression levels determine the extent ofcMyconcogenic translocations and the incidence of B cell tumor development

(2008) Makiko Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of class switch recombination and somatic mutation by AID phosphorylation

(2008) Kevin M. McBride et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-181b negatively regulates activation-induced cytidine deaminase in B cells

(2008) Virginia G. de Yébenes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasomal degradation restricts the nuclear lifespan of AID

(2008) Said Aoufouchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

(2008) A Takai et al.   ONCOGENE

APOBEC3G: an intracellular centurion

(2008) Y.-L. Chiu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins

(2008) J. Hauser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney

(2007) Hong Ming Shen et al.   MOLECULAR IMMUNOLOGY