HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

Lupus-prone MRL/faslpr/lprmice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

(2009) Hong Zan et al.   AUTOIMMUNITY

The Biochemistry of Somatic Hypermutation

(2008) Jonathan U. Peled et al.   Annual Review of Immunology

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

(2008) Grace Teng et al.   IMMUNITY

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY

Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis

(2008) Chuancang Jiang et al.   IMMUNOLOGY

AID expression levels determine the extent ofcMyconcogenic translocations and the incidence of B cell tumor development

(2008) Makiko Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: A post-cleavage role for AID

(2008) Hong Zan et al.   MOLECULAR IMMUNOLOGY