Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Microstructured templates for directed growth and vascularization of soft tissue in vivo

(2011) Ying Zheng et al.   BIOMATERIALS

A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology

(2011) Yandong Gao et al.   BIOMEDICAL MICRODEVICES

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

(2011) Hossein Tavana et al.   BIOMEDICAL MICRODEVICES

Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics

(2011) Deepak Choudhury et al.   Biomicrofluidics

Continuously perfused microbubble array for 3D tumor spheroid model

(2011) Sivaprakash Agastin et al.   Biomicrofluidics

A microfluidic membrane device to mimic critical components of the vascular microenvironment

(2011) Suthan Srigunapalan et al.   Biomicrofluidics

(Micro)managing the mechanical microenvironment

(2011) Christopher Moraes et al.   Integrative Biology

High-throughput combinatorial cell co-culture using microfluidics

(2011) Ethan Tumarkin et al.   Integrative Biology

Multi-Step Usage of in Vivo Models During Rational Drug Design and Discovery

(2011) Charles H. Williams et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Ring-shaped neuronal networks: a platform to study persistent activity

(2011) Ashwin Vishwanathan et al.   LAB ON A CHIP

High fidelity neuronal networks formed by plasma masking with a bilayer membrane: analysis of neurodegenerative and neuroprotective processes

(2011) Heike Hardelauf et al.   LAB ON A CHIP

Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip

(2011) Tsi-Hsuan Hsu et al.   LAB ON A CHIP

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays

(2011) Véronique Lecault et al.   NATURE METHODS

Effective Understanding of the Human Body Organs: A Role-Playing Activity for Deep Learning

(2010) Abour H. Cherif et al.   AMERICAN BIOLOGY TEACHER

Microfluidic Western Blot

(2010) Wenying Pan et al.   ANALYTICAL CHEMISTRY

Overflow Microfluidic Networks for Open and Closed Cell Cultures on Chip

(2010) Robert D. Lovchik et al.   ANALYTICAL CHEMISTRY

Liver-Assist Device With a Microfluidics-Based Vascular Bed in an Animal Model

(2010) Wen-Ming Hsu et al.   ANNALS OF SURGERY

Expanding the Available Assays: Adapting and Validating In-Cell Westerns in Microfluidic Devices for Cell-Based Assays

(2010) Amy L. Paguirigan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels

(2010) Gavrielle M. Price et al.   BIOMATERIALS

Micropatterning neural cell cultures in 3D with a multi-layered scaffold

(2010) Anja Kunze et al.   BIOMATERIALS

Layered patterning of hepatocytes in co-culture systems using microfabricated stencils

(2010) Cheul Cho et al.   BIOTECHNIQUES

Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device

(2010) Huipeng Ma et al.   ELECTROPHORESIS

Regulating microenvironmental stimuli for stem cells and cancer cells using microsystems

(2010) Joong Yull Park et al.   Integrative Biology

Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells

(2010) Yu-suke Torisawa et al.   Integrative Biology

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Microdevice to capture colon crypts for in vitro studies

(2010) Yuli Wang et al.   LAB ON A CHIP

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Building and manipulating neural pathways with microfluidics

(2010) Yevgeny Berdichevsky et al.   LAB ON A CHIP

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

(2010) Vasiliy N. Goral et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits

(2010) Heike Hardelauf et al.   LAB ON A CHIP

Three-dimensional cell-dense constructs containing endothelial cell-networks are an effective tool for in vivo and in vitro vascular biology research

(2010) Sachiko Sekiya et al.   MICROVASCULAR RESEARCH

Automated microfluidic protein immunoblotting

(2010) Mei He et al.   Nature Protocols

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Oxygen-Controlled Three-Dimensional Cultures to Analyze Tumor Angiogenesis

(2010) Scott S. Verbridge et al.   TISSUE ENGINEERING PART A

Microfluidic Culture Models of Tumor Angiogenesis

(2010) Abraham D. Stroock et al.   TISSUE ENGINEERING PART A

Application of microfluidic technology to pancreatic islet research: first decade of endeavor

(2010) Yong Wang et al.   Bioanalysis

A microfluidic wound-healing assay for quantifying endothelial cell migration

(2009) Andries D. van der Meer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Review of cell and particle trapping in microfluidic systems

(2009) J. Nilsson et al.   ANALYTICA CHIMICA ACTA

Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus

(2009) Hirofumi Shimizu et al.   BIOMATERIALS

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

(2009) Amy Y. Hsiao et al.   BIOMATERIALS

A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays

(2009) Christopher Moraes et al.   BIOMATERIALS

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

(2009) Jaewon Park et al.   BIOMEDICAL MICRODEVICES

An open-access microfluidic model for lung-specific functional studies at an air-liquid interface

(2009) Divya D. Nalayanda et al.   BIOMEDICAL MICRODEVICES

The forgotten sides of acute lung injury and acute respiratory distress syndrome

(2009) Paolo Pelosi   Current Opinion in Critical Care

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress

(2009) Jianbo Shao et al.   LAB ON A CHIP

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP

Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation

(2009) Christopher Moraes et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Dynamics of Liquid Plugs of Buffer and Surfactant Solutions in a Micro-Engineered Pulmonary Airway Model

(2009) Hossein Tavana et al.   LANGMUIR

Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells

(2009) H. Tavana et al.   NATURE MATERIALS

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs

(2009) D.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays

(2008) M. Shein et al.   BIOMEDICAL MICRODEVICES

In vitro analysis of a hepatic device with intrinsic microvascular-based channels

(2008) Amedeo Carraro et al.   BIOMEDICAL MICRODEVICES

Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling

(2008) Peter J. Mack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models

(2008) Hiroshi Kimura et al.   LAB ON A CHIP

Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging

(2008) Vernella Vickerman et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics

(2008) Colin L. Walsh et al.   LAB ON A CHIP

Unsteady propagation of a liquid plug in a liquid-lined straight tube

(2008) Hideki Fujioka et al.   PHYSICS OF FLUIDS

Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates

(2007) Jaesung Park et al.   BIOTECHNOLOGY AND BIOENGINEERING

Differential gene responses in endothelial cells exposed to a combination of shear stress and cyclic stretch

(2007) Masahisa Toda et al.   JOURNAL OF BIOTECHNOLOGY

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS