Article
Immunology
Yuhki Indo, Shugo Kitahara, Mikado Tomokiyo, Shota Araki, Md Aminul Islam, Binghui Zhou, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
Summary: The study identified L. salivarius strains FFIG35 and FFIG58 with potent immunomodulatory effects, enhancing resistance to rotavirus infection in PIE cells and regulating immune responses in superinfection models. These strains modulated negative regulators of the TLR signaling pathway in epithelial cells, highlighting their potential to be used for developing functional feeds to improve immune health and reduce intestinal infections in weaned piglets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Andrea Toschi, Andrea Piva, Ester Grilli
Summary: The study aimed to evaluate the effects of phenolic compounds on intestinal oxidation and barrier integrity. The results showed that phenol-rich botanicals had a positive effect on intestinal cells and could potentially improve intestinal barrier function. This is important for controlling gut barrier function and reducing the negative effects of oxidative stress.
Review
Immunology
Zhiqiang Jiang, Chuan Wu
Summary: Intestinal Treg cells play a crucial role in immune repression and tolerance, with distinct functional and phenotypical characteristics compared to Treg cells in other organs. The interactions between intestinal Treg cells, microbiota, and gut epithelium contribute to controlling intestinal physiology and maintaining gut immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jeroen M. J. Tas, Ja-Hyun Koo, Ying-Cing Lin, Zhenfei Xie, Jon M. Steichen, Abigail M. Jackson, Blake M. Hauser, Xuesong Wang, Christopher A. Cottrell, Jonathan L. Torres, John E. Warner, Kathrin H. Kirsch, Stephanie R. Weldon, Bettina Groschel, Bartek Nogal, Gabriel Ozorowski, Sandhya Bangaru, Nicole Phelps, Yumiko Adachi, Saman Eskandarzadeh, Michael Kubitz, Dennis R. Burton, Daniel Lingwood, Aaron G. Schmidt, Usha Nair, Andrew B. Ward, William R. Schief, Facundo D. Batista
Summary: In this study using mouse models for preclinical SARS-CoV and HIV, it was demonstrated that antibodies generated during primary humoral responses can shape the recruitment of naive B cells to germinal centers during secondary exposures. The directionality and intensity of this effect are determined by antibody concentration, affinity, and epitope specificity.
Review
Immunology
Takayuki Ogino, Kiyoshi Takeda
Summary: Antigen-presenting cells, such as macrophages and dendritic cells, play a crucial role in the differentiation of T cells and activation of adaptive immune response. Different subsets of these cells in the intestinal lamina propria have been identified and shown to contribute to the maintenance of intestinal homeostasis by interacting with intestinal bacteria. Further research on these antigen-presenting cells in the intestinal tract may help in understanding the pathology of inflammatory bowel disease and developing novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Michael P. P. Jeffrey, Chad W. W. MacPherson, Thomas A. A. Tompkins, Julia M. M. Green-Johnson
Summary: In this study, the ability of certain lactic acid bacteria to modulate inflammatory gene transcription and cytokine production in interactions between intestinal epithelial cells and antigen-presenting cells was investigated. The results demonstrated that the secretome of the bacteria could suppress pro-inflammatory responses and enhance the integrity of the epithelial barrier.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Semir Beyaz, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, Moshe Biton, Karthik Shekhar, Onur Eskiocak, Katherine Papciak, Kadir Ozler, Mohammad Almeqdadi, Brian Yueh, Miriam Fein, Damodaran Annamalai, Eider Valle-Encinas, Aysegul Erdemir, Karoline Dogum, Vyom Shah, Aybuke Alici-Garipcan, Hannah V. Meyer, Deniz M. Ozata, Eran Elinav, Alper Kucukural, Pawan Kumar, Jeremy P. McAleer, James G. Fox, Christoph A. Thaiss, Aviv Regev, Jatin Roper, Stuart H. Orkin, Omer H. Yilmaz
Summary: A high-fat diet reduces MHC class II gene expression in intestinal epithelial cells, affecting microbiome diversity. The expression of epithelial MHC class II is regulated by intestinal flora through PRR and IFNg signaling. MHC-II-ISCs have greater tumor-initiating capacity compared to MHC-II+ counterparts under the influence of a high-fat diet, showing the role of immune surveillance in suppressing tumorigenesis.
Article
Cell Biology
Jinyu Wang, Michela Manni, Anne Baerenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Michal Stanczak, Alfred Zippelius, David Koenig, Natalia Rodrigues Manutano, Heinz Laeubli
Summary: Interactions between sialylated glycans and Siglec receptors have been identified as a potential new immune checkpoint to improve anticancer immunity. In this study, it was found that cancer-associated dendritic cells (DCs) have a high expression of inhibitory Siglecs, which can impair their maturation states. Furthermore, removing these inhibitory Siglecs from DCs enhances their capability to prime antigen-specific T cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Aun Raza, Gustavo Rodrigues Rossi, Taskeen Iqbal Janjua, Fernando Souza-Fonseca-Guimaraes, Amirali Popat
Summary: Natural killer (NK) cells are being explored as a major target for cancer immunotherapies, particularly as cellular therapy modalities due to their lower toxicity compared to T lymphocytes. However, there are challenges regarding the activation, genetic engineering resistance, and large-scale expansion of NK cell-based therapy. The use of nanobiomaterials has emerged as a promising solution to address these challenges and enhance the anticancer responses of NK cells for safer and more effective immunotherapy. Smart materials may play a crucial role in activating NK cells as a potential cellular therapy of the future.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Pilar Samperio Ventayol, Petra Geiser, Maria Letizia Di Martino, Alexandra Florbrant, Stefan A. Fattinger, Naemi Walder, Eduardo Sima, Feng Shao, Nelson O. Gekara, Magnus Sundbom, Wolf-Dietrich Hardt, Dominic-Luc Webb, Per M. Hellstrom, Jens Eriksson, Mikael E. Sellin
Summary: The study found that infection with Salmonella Typhimurium triggers focal contractions in intestinal epithelial cells, which are initiated by the NAIP/NLRC4 inflammasome and can prevent infected cell death and expulsion, thereby protecting the integrity of the intestinal epithelium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Naveen Parmar, Kyle Burrows, Pia M. Vornewald, Havard T. Lindholm, Rosalie T. Zwiggelaar, Alberto Diez-Sanchez, Mara Martin-Alonso, Madeleine Fosslie, Bruce A. Vallance, John Arne Dahl, Colby Zaph, Menno J. Oudhoff
Summary: The study highlights the importance of the epigenetic regulation by LSD1 in intestinal epithelial cells in protecting the host from infections. LSD1 is crucial for goblet cell maturation and response to cytokines, which play a role in defending against bacterial and parasitic infections. Targeting LSD1 may offer a potential therapeutic strategy for infectious diseases in the future.
Article
Oncology
Ichwaku Rastogi, Douglas G. McNeel
Summary: DNA vaccines have shown limited immunogenicity in human clinical trials. B cells, not DCs, are the primary antigen-presenting cells for DNA-encoded antigens. B cells can translate the encoded antigens, but DCs are required for activating CD8 T cells. Further study of B cells as APCs is important for improving the efficacy of DNA vaccines.
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ichwaku Rastogi, Donghwan Jeon, Jena E. E. Moseman, Anusha Muralidhar, Hemanth K. Potluri, Douglas G. G. McNeel
Summary: This review discusses the role and function of B cells in the humoral immune system, as well as their ability to act as antigen presenting cells. B cells have been shown to activate antigen-specific T cells and have regulatory and cytotoxic effects. The importance of B cells within the tumor microenvironment is increasingly recognized, and B cells are being evaluated as cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Saad Y. Salim, Pang Y. Young, Thomas A. Churchill, Rachel G. Khadaroo
JOURNAL OF SURGICAL RESEARCH
(2017)
Article
Pathology
Sa'ad Y. Salim, Manuel A. Silva, Asa V. Keita, Marie Larsson, Peter Andersson, Karl-Eric Magnusson, Mary H. Perdue, Johan D. Soederholm
AMERICAN JOURNAL OF PATHOLOGY
(2009)
Review
Gastroenterology & Hepatology
Sa'ad Y. Salim, Johan D. Soderholm
INFLAMMATORY BOWEL DISEASES
(2011)
Article
Medicine, Research & Experimental
Benoit Chassaing, Nathalie Rolhion, Amelie de Vallee, Sa'ad Y. Salim, Maelle Prorok-Hamon, Christel Neut, Barry J. Campbell, Johan D. Soderholm, Jean-Pierre Hugot, Jean-Frederic Colombel, Arlette Darfeuille-Michaud
JOURNAL OF CLINICAL INVESTIGATION
(2011)
Article
Oncology
A. V. Keita, S. Y. Salim, T. Jiang, P-C Yang, L. Franzen, P. Soderkvist, K-E Magnusson, J. D. Soderholm
JOURNAL OF PATHOLOGY
(2008)
Article
Multidisciplinary Sciences
Naomi S. C. Hotte, Saad Y. Salim, Robert H. Tso, Eric J. Albert, Phil Bach, John Walker, Levinus A. Dieleman, Richard N. Fedorak, Karen L. Madsen
Article
Microbiology
S. Y. Salim, P. Y. Young, C. M. Lukowski, K. L. Madsen, B. Sis, T. A. Churchill, R. G. Khadaroo
BENEFICIAL MICROBES
(2013)
Meeting Abstract
Gastroenterology & Hepatology
Naomi Hotte, Saad Y. Salim, Robert Tso, Levinus A. Dieleman, Richard N. Fedorak, Karen Madsen
Meeting Abstract
Gastroenterology & Hepatology
Lisa Kish, Saad Y. Salim, Naomi Hotte, Robert Tso, Caroline D. Ethier, Renaud Vincent, Gilaad G. Kaplan, Herman Barkema, Karen Madsen
Article
Gastroenterology & Hepatology
Manuel A. Silva, Rodrigo Quera, Jorge Valenzuela, Sa'ad Y. Salim, Johan D. Soderholm, Mary H. Perdue
DIGESTIVE DISEASES AND SCIENCES
(2008)
Article
Pharmacology & Pharmacy
Elisabet Gullberg, Asa V. Keita, Sa'ad Y. Salim, Margaretha Andersson, Karin D. Caldwell, Johan D. Soderholm, Per Artursson
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2006)
Article
Medicine, Research & Experimental
ÅV Keita, E Gullberg, AC Ericson, SY Salim, C Wallon, A Kald, P Artursson, JD Söderholm
LABORATORY INVESTIGATION
(2006)
Article
Gastroenterology & Hepatology
Y Tu, S Salim, J Bourgeois, V Di Leo, EJ Irvine, JK Marshall, MH Perdue
Meeting Abstract
Biochemistry & Molecular Biology
YH Tu, S Salim, J Bourgeois, V Di Leo, EJ Irvine, JK Marshall, MH Perdue