Article
Infectious Diseases
Elisa Heuser, Karsten Becker, Evgeny A. Idelevich
Summary: Sodium bituminosulfonate has been shown to have bactericidal activity against Staphylococcus aureus and is effective at higher concentrations.
Article
Infectious Diseases
Cristina El Haj, Mads Lichtenberg, Karen Leth Nielsen, Thomas Bjarnsholt, Peter ostrup Jensen
Summary: This study evaluated the role of ROS in the bactericidal activity of daptomycin against Staphylococcus aureus biofilms. The presence of catalase was found to protect the biofilm by reducing ROS production and increasing bacterial survival. Induction of cytotoxic ROS formation by daptomycin was verified, and only the highest concentration of daptomycin reduced bacterial survival and increased ROS formation in the resistant biofilm.
Article
Microbiology
Agustina D. R. Nurcahyanti, Jullietta Lady, Michael Wink
Summary: The increasing prevalence of antimicrobial resistance (AMR) in Staphylococcus aureus against commonly used antibiotics is a major global health issue. The current study aimed to investigate whether fucoxanthin can inhibit S. aureus including the strains resistant to methicillin and to investigate whether fucoxanthin can enhance the therapeutic effect of cefotaxime, a widely prescribed 3rd-generation cephalosporin & beta;-lactam antibiotic known to exhibit resistance in certain cases. Synergistic bactericidal effect was observed in all strains of S. aureus when fucoxanthin was combined with cefotaxime at a specific concentration ratio, suggesting the potential of fucoxanthin in enhancing the therapeutic efficacy of cefotaxime.
CURRENT MICROBIOLOGY
(2023)
Article
Chemistry, Applied
Renata Freire Alves Pereira, Lialyz Soares Pereira Andre, Felipe Ramos Pinheiro, Julia Scaffo, Arthur Luiz Correa, Tainara Aparecida Nunes Ribeiro, Daniela Sachs, Leandro Rocha, Fabio Aguiar-Alves
Summary: In this study, the Hypericum brasiliense extract exhibited bactericidal activity against a multidrug-resistant S. aureus strain and inhibited biofilm formation. These promising results suggest that Hypericum brasiliense extract could be a strong candidate for treating S. aureus infections, including anti-biofilm therapy.
NATURAL PRODUCT RESEARCH
(2022)
Article
Microbiology
Morgan M. Severn, Michael R. Williams, Ali Shahbandi, Zoie L. Bunch, Laurie M. Lyon, Amber Nguyen, Livia S. Zaramela, Daniel A. Todd, Karsten Zengler, Nadja B. Cech, Richard L. Gallo, Alexander R. Horswill
Summary: Human skin is home to a variety of commensal bacteria, including Staphylococcus hominis, which plays an important role in preventing Staphylococcus aureus colonization and infection. It produces multiple signaling molecules that inhibit the virulence factor regulation system of S. aureus and other related species. Synthetic versions of these molecules have shown protective effects against S. aureus-associated skin injuries in animal models.
Article
Microbiology
Shuhan Guan, Hangqian Yu, Hua Xiang, Li Wang, Jingyu Liu, Anfang Wu, Jianze Zheng, Hongbo Dong, Lin Wang, Dacheng Wang
Summary: Antibiotic resistance is spreading rapidly, causing a public health crisis. There is an urgent need for new antimicrobial agents against MRSA. WYBQ-4 has been found to have potent bactericidal activity against MRSA and shows significant efficacy in in vitro and in vivo experiments. This compound has the potential to control MRSA infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Xiaohong Li, Shujuan Wang, Raphael Nyaruaba, Huan Liu, Hang Yang, Hongping Wei
Summary: The chimeric lysin ClyC has Ca2+-enhanced bactericidal activity against all S. aureus strains, including MRSA. It shows high activity, significantly reduced effective concentration when combined with penicillin G, and improved survival rates in a mouse model of S. aureus bacteremia. ClyC is a promising candidate against S. aureus infections.
Review
Biochemistry & Molecular Biology
Denis Swolana, Robert D. Wojtyczka
Summary: The article introduces the effects of Staphylococcus epidermidis and Staphylococcus aureus on human health, as well as silver nanoparticles as a potential new substance for neutralizing bacterial cells. By reviewing the data on the activity of silver nanoparticles in inhibiting bacterial growth and biofilm formation, it provides insights for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shisong Jing, Li Wang, Tiedong Wang, Lianghai Fan, Lin Chen, Hua Xiang, Yan Shi, Dacheng Wang
Summary: The study identified a compound named myricetin that effectively inhibits the activity of ClpP, reduces the pathogenicity of Staphylococcus aureus in vivo, enhances the efficacy of traditional antibiotics against MRSA, and protects mice from fatal lung infections caused by MRSA.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xue Bai, Yong Shen, Tiehua Zhang, Rizeng Meng, Yan Zhang, Yanhong Deng, Na Guo
Summary: This study aimed to evaluate the anti-biofilm effects of natural product biochanin A against Staphylococcus aureus. Results showed that biochanin A effectively eradicated established S. aureus biofilms on different food-contact materials. Molecular docking also demonstrated that biochanin A conducted strong interactions with biofilm-related proteins.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Immunology
LewisOscar Felix, Biswajit Mishra, Rajamohammed Khader, Narchonai Ganesan, Eleftherios Mylonakis
Summary: Alpha mangostin exhibits antimicrobial activity against MRSA persisters and biofilms, causing membrane permeabilization and bacterial cell death. It also inhibits biofilm formation and attachment and down-regulates genes associated with persister cell and biofilm formation. In vivo experiments show that alpha mangostin increases the survival of MRSA-infected larvae. These findings contribute to our understanding of the antimicrobial activity and toxicity of this natural compound.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Andrew Michael Frey, Dale Chaput, Lindsey Neil Shaw
Summary: In this study, two N-terminomics methods were applied to investigate the cleavage of human serum proteins by the S. aureus V8 protease, leading to the discovery of 85 host-protein targets, including complement, iron sequestration, clotting cascade, and host protease inhibitor proteins. The protease V8 disrupts host protein function through cleavage sites, providing insights into its role in S. aureus pathogenesis.
Article
Biochemistry & Molecular Biology
Amal Alrashidi, Mohammed Jafar, Niamh Higgins, Ciara Mulligan, Carmine Varricchio, Ryan Moseley, Vildan Celiksoy, David M. J. Houston, Charles M. Heard
Summary: The combination of pomegranate rind extract and Zn (II) ions shows synergistic bactericidal activity against various bacterial strains, indicating potential for the development of a therapeutic system with demonstrable antimicrobial activity for topical applications, such as MRSA infections.
Article
Chemistry, Applied
Jinjin Tong, Xiaolin Hou, Defeng Cui, Wu Chen, Hua Yao, Benhai Xiong, Lirong Cai, Hua Zhang, Linshu Jiang
Summary: This study prepared a novel berberine hydrochloride-carboxymethyl chitosan hydrogel (BH-CMCH) with excellent properties and demonstrated its antibacterial activity against Staphylococcus aureus in a rat mastitis model. Proteomics analysis indicated that BH-CMCH enhanced autolysosome degradation and activated the lysosomal pathway to promote the innate immune response.
CARBOHYDRATE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
