Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection

(2011) Anne Müller et al.   Cell Communication and Signaling

Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity

(2011) Gerard F. Hoyne   Clinical & Developmental Immunology

Relationship between Immunity to Borrelia burgdorferi Outer-surface Protein A (OspA) and Lyme Arthritis

(2011) Allen C. Steere et al.   CLINICAL INFECTIOUS DISEASES

Molecular Mimicry as a Mechanism of Autoimmune Disease

(2011) Matthew F. Cusick et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Guillain-Barré Syndrome: Modern Theories of Etiology

(2011) Todd A. Hardy et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells

(2011) Tomohisa Sujino et al.   GASTROENTEROLOGY

IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritis

(2011) J Hazlett et al.   GENES AND IMMUNITY

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Control of antiviral immunity by pattern recognition and the microbiome

(2011) Iris K. Pang et al.   IMMUNOLOGICAL REVIEWS

Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity

(2011) Takumi Kawasaki et al.   IMMUNOLOGICAL REVIEWS

Twin studies in autoimmune disease: Genetics, gender and environment

(2011) Dimitrios P. Bogdanos et al.   JOURNAL OF AUTOIMMUNITY

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model

(2011) T. L. Van Belle et al.   JOURNAL OF IMMUNOLOGY

Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis

(2011) K. Raddassi et al.   JOURNAL OF IMMUNOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Genomics and the Multifactorial Nature of Human Autoimmune Disease

(2011) Judy H. Cho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

(2011) M. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

(2011) M. A. Kriegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding rheumatic fever

(2011) Pedro Ming Azevedo et al.   RHEUMATOLOGY INTERNATIONAL

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Commensal flora and the regulation of inflammatory and autoimmune responses

(2011) Jan Kranich et al.   SEMINARS IN IMMUNOLOGY

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

(2011) Kamran Ghoreschi et al.   TRENDS IN IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Transient immunosuppression: a bridge between infection and the atypical autoimmunity of Guillain-Barré syndrome?

(2010) I. Steiner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Viruses, autoimmunity and immunoregulation

(2010) C. M. Filippi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infection and apoptosis as a combined inflammatory trigger

(2010) Miriam Beer Torchinsky et al.   CURRENT OPINION IN IMMUNOLOGY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

(2010) Anne Puel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restricted Microbiota and Absence of Cognate TCR Antigen Leads to an Unbalanced Generation of Th17 Cells

(2010) M. Lochner et al.   JOURNAL OF IMMUNOLOGY

IL-17RC Is Required for IL-17A- and IL-17F-Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Increased Interleukin 21 (IL-21) and IL-23 Are Associated with Increased Disease Activity and with Radiographic Status in Patients with Early Rheumatoid Arthritis

(2010) T. K. RASMUSSEN et al.   JOURNAL OF RHEUMATOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The role of AIRE in human autoimmune disease

(2010) Eitan M. Akirav et al.   Nature Reviews Endocrinology

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders

(2010) H.-K. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency

(2010) C. E. Teh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Development, regulation and functional capacities of Th17 cells

(2010) Keiji Hirota et al.   Seminars in Immunopathology

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

(2009) L. Melis et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Reactive Arthritis after Enteric Infections in the United States: The Problem of Definition

(2009) John M. Townes   CLINICAL INFECTIOUS DISEASES

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

(2009) A. S. Lee et al.   DIABETOLOGIA

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Autoimmunity risk alleles in costimulation pathways

(2009) Lisa M. Maier et al.   IMMUNOLOGICAL REVIEWS

Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response

(2009) Megan Livingston et al.   IMMUNOLOGY AND CELL BIOLOGY

Viral triggers for autoimmunity: Is the ‘glass of molecular mimicry’ half full or half empty?

(2009) Urs Christen et al.   JOURNAL OF AUTOIMMUNITY

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 Signaling-Independent Central Nervous System Autoimmunity Is Negatively Regulated by TGF- 

(2009) I. Gonzalez-Garcia et al.   JOURNAL OF IMMUNOLOGY

Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I

(2009) E. S. Husebye et al.   JOURNAL OF INTERNAL MEDICINE

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

(2009) Miriam Beer Torchinsky et al.   NATURE

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation

(2009) Benjamin R Marks et al.   NATURE IMMUNOLOGY

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

(2009) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study

(2008) J M Townes et al.   ANNALS OF THE RHEUMATIC DISEASES

Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis

(2008) Robert Root-Bernstein et al.   AUTOIMMUNITY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

IL23R: a susceptibility locus for celiac disease and multiple sclerosis?

(2008) C Núñez et al.   GENES AND IMMUNITY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

(2008) Junbao Yang et al.   JOURNAL OF AUTOIMMUNITY

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease

(2008) Koji Hase et al.   PLoS One

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

(2008) Ying Liu et al.   PLoS Genetics

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?

(2007) Erik Lubberts   CYTOKINE