Control of antiviral immunity by pattern recognition and the microbiome

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Lactobacillus GG as an immune adjuvant for live-attenuated influenza vaccine in healthy adults: a randomized double-blind placebo-controlled trial

(2011) L E Davidson et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes

(2011) Simone Nish et al.   IMMUNITY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Regulation of the Antimicrobial Response by NLR Proteins

(2011) Eran Elinav et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Genome–virome interactions: examining the role of common viral infections in complex disease

(2011) Ellen F. Foxman et al.   NATURE REVIEWS MICROBIOLOGY

Unravelling the effects of the environment and host genotype on the gut microbiome

(2011) Aymé Spor et al.   NATURE REVIEWS MICROBIOLOGY

Shifting the balance: antibiotic effects on host–microbiota mutualism

(2011) Benjamin P. Willing et al.   NATURE REVIEWS MICROBIOLOGY

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

The intestinal epithelial barrier in the control of homeostasis and immunity

(2011) Maria Rescigno   TRENDS IN IMMUNOLOGY

The Intestinal Microbiota and Viral Susceptibility

(2011) Julie K. Pfeiffer et al.   Frontiers in Microbiology

Intestinal Bacteria and the Regulation of Immune Cell Homeostasis

(2010) David A. Hill et al.   Annual Review of Immunology

Viral proteins function as ion channels

(2010) Kai Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

The role of NOD-like Receptors in shaping adaptive immunity

(2010) Adam Williams et al.   CURRENT OPINION IN IMMUNOLOGY

Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide

(2010) T. Umenai et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics

(2010) Ruben Hummelen et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Probiotic Yogurt Consumption is Associated With an Increase of CD4 Count Among People Living With HIV/AIDS

(2010) Stephanie L. Irvine et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Inflammasomes and Anti-Viral Immunity

(2010) Vijay A. K. Rathinam et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection

(2010) S.-U. Seo et al.   JOURNAL OF VIROLOGY

The Innate Immune Adaptor Molecule MyD88 Restricts West Nile Virus Replication and Spread in Neurons of the Central Nervous System

(2010) K. J. Szretter et al.   JOURNAL OF VIROLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Probiotics and the gut microbiota in intestinal health and disease

(2010) Mélanie G. Gareau et al.   Nature Reviews Gastroenterology & Hepatology

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

(2010) P. van Baarlen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteroviruses and type 1 diabetes: towards a better understanding of the relationship

(2010) Hela Jaïdane et al.   REVIEWS IN MEDICAL VIROLOGY

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Inflammasomes as mediators of immunity against influenza virus

(2010) Iris K. Pang et al.   TRENDS IN IMMUNOLOGY

Replication-independent activation of human plasmacytoid dendritic cells by the paramyxovirus SV5 Requires TLR7 and autophagy pathways

(2010) Mary J. Manuse et al.   VIROLOGY

Th17 lineage commitment and HIV-1 pathogenesis

(2010) Petronela Ancuta et al.   Current Opinion in HIV and AIDS

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

(2010) Aisha Nazli et al.   PLoS Pathogens

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

(2010) Mehul S. Suthar et al.   PLoS Pathogens

The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

(2010) Kathrin Endt et al.   PLoS Pathogens

Regulatory T Cells in the Control of Host-Microorganism Interactions

(2009) Yasmine Belkaid et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Connections between antiviral defense and autoimmunity

(2009) Daniel B Stetson   CURRENT OPINION IN IMMUNOLOGY

Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan

(2009) Chung-Hang Leung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

(2009) Terrence Town et al.   IMMUNITY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice

(2009) Naoyoshi Maeda et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Probiotics for the prevention of respiratory tract infections: a systematic review

(2009) Evridiki K. Vouloumanou et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Coordination of tolerogenic immune responses by the commensal microbiota

(2009) June L. Round et al.   JOURNAL OF AUTOIMMUNITY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The core gut microbiome, energy balance and obesity

(2009) Peter J. Turnbaugh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi

(2009) Marko Kerac et al.   LANCET

Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis

(2009) D A Hill et al.   Mucosal Immunology

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Influence of microbial environment on autoimmunity

(2009) Alexander V Chervonsky   NATURE IMMUNOLOGY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

(2009) A. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

(2009) Thierry Boge et al.   VACCINE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

(2008) Giulia Marchetti et al.   AIDS

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology

(2008) S. Baenziger et al.   BLOOD

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Constitutive Crosspresentation of Tissue Antigens by Dendritic Cells Controls CD8+ T Cell Tolerance In Vivo

(2008) Nancy Luckashenak et al.   IMMUNITY

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

(2008) Colby Zaph et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages

(2008) Minja Miettinen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

(2008) S. Daffis et al.   JOURNAL OF VIROLOGY

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

(2008) V Cecchinato et al.   Mucosal Immunology

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

(2008) Katharina Brandl et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

(2008) Sven Burgdorf et al.   NATURE IMMUNOLOGY

Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

(2008) Manuela Raffatellu et al.   NATURE MEDICINE

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus

(2008) V. G. Bhoj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

(2008) Les Dethlefsen et al.   PLOS BIOLOGY