Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells

Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

(2015) Huixia Li et al.   CELL CYCLE

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

(2015) Sini Heinonen et al.   DIABETES

Restoration of Autophagy Alleviates Hepatic ER Stress and Impaired Insulin Signalling Transduction in High Fructose-Fed Male Mice

(2015) Hao Wang et al.   ENDOCRINOLOGY

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection

(2015) Virginia Pardo et al.   FOOD AND CHEMICAL TOXICOLOGY

The mitochondrial Ca2+ uniporter complex

(2015) J. Kevin Foskett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis

(2014) Chih-Hao Wang et al.   HUMAN MOLECULAR GENETICS

Essential Role of Mitochondrial Ca2+Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells

(2014) Xianglan Quan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Impaired Mitochondrial Dynamics and Bioenergetics in Diabetic Skeletal Muscle

(2014) Ruohai Liu et al.   PLoS One

Hypermethylation of Cox5a Promoter Is Associated with Mitochondrial Dysfunction in Skeletal Muscle of High Fat Diet-Induced Insulin Resistant Rats

(2014) Ying-ying Gong et al.   PLoS One

The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

(2013) Sheree D. Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

(2013) Lale Ozcan et al.   Cell Metabolism

FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis

(2013) Chunjiong Wang et al.   HEPATOLOGY

Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

(2013) P. A. Parone et al.   JOURNAL OF NEUROSCIENCE

The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications

(2013) Saverio Marchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

(2012) Chih-Hao Wang et al.   FEBS Journal

Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle

(2012) N. C. Chang et al.   HUMAN MOLECULAR GENETICS

Molecular Identity and Functional Properties of the Mitochondrial Na+/Ca2+Exchanger

(2012) Raz Palty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Ca2+Uptake 1 (MICU1) and Mitochondrial Ca2+Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells

(2012) Muhammad Rizwan Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes

(2011) A. I. Schmid et al.   DIABETES CARE

The Ca2+/Calmodulin-Dependent Protein Kinase Kinase, CaMKK2, Inhibits Preadipocyte Differentiation

(2011) Fumin Lin et al.   ENDOCRINOLOGY

Interaction between Mitochondria and the Endoplasmic Reticulum: Implications for the Pathogenesis of Type 2 Diabetes Mellitus

(2011) Jaechan Leem et al.   Experimental Diabetes Research

Mitochondria and endoplasmic reticulum: Mitochondria–endoplasmic reticulum interplay in type 2 diabetes pathophysiology

(2011) Jennifer Rieusset   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol attenuates high-fat diet–induced insulin resistance by influencing skeletal muscle lipid transport and subsarcolemmal mitochondrial β-oxidation

(2011) Lu-Lu Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus

(2011) Toru Yamaguchi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes

(2010) Chih-Hao Wang et al.   Annals of the New York Academy of Sciences

The fateful encounter of mitochondria with calcium: How did it happen?

(2010) Ernesto Carafoli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

An Inositol 1,4,5-Triphosphate (IP3)-IP3Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes

(2010) A. E. Contreras-Ferrat et al.   ENDOCRINOLOGY

Inflammation and insulin resistance induced bytrans-10,cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes

(2010) Arion Kennedy et al.   JOURNAL OF LIPID RESEARCH

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Adipokines as regulators of muscle metabolism and insulin sensitivityThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) David J. Dyck   Applied Physiology Nutrition and Metabolism

Molecular and Metabolic Evidence for Mitochondrial Defects Associated With  -Cell Dysfunction in a Mouse Model of Type 2 Diabetes

(2009) H. Lu et al.   DIABETES

Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice

(2009) Y.-F. Chen et al.   GENES & DEVELOPMENT

Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance

(2008) Lindsey N. Sutherland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The versatility of mitochondrial calcium signals: From stimulation of cell metabolism to induction of cell death

(2008) Alessandro Rimessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria and calcium in health and disease

(2008) M DUCHEN et al.   CELL CALCIUM

CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes

(2008) Ming Fai Yip et al.   Cell Metabolism

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Calreticulin inhibits commitment to adipocyte differentiation

(2008) Eva Szabo et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM