Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2

(2014) Meiling Li et al.   CELLULAR SIGNALLING

Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome

(2014) Huixia Li et al.   ENDOCRINOLOGY

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4+ Foxp3+regulatory T cells

(2014) Ya Hu et al.   IMMUNOLOGY

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

(2014) Cui Liu et al.   PLoS One

Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanism

(2013) Bo Zhou et al.   CELL CYCLE

Osteocalcin Reverses Endoplasmic Reticulum Stress and Improves Impaired Insulin Sensitivity Secondary to Diet-Induced Obesity Through Nuclear Factor-κB Signaling Pathway

(2013) Bo Zhou et al.   ENDOCRINOLOGY

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

(2013) Jinlong Jian et al.   FEBS LETTERS

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

(2013) Nima Etemadi et al.   IMMUNOLOGY AND CELL BIOLOGY

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance

(2013) Hua Qu et al.   MEDIATORS OF INFLAMMATION

Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome

(2013) Hye Jin Yoo et al.   PLoS One

A Shift to Organismal Stress Resistance in Programmed Cell Death Mutants

(2013) Meredith E. Judy et al.   PLoS Genetics

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification

(2013) Masashi Masuda et al.   Journal of the American Heart Association

Progranulin Bridges Energy Homeostasis and Fronto-Temporal Dementia

(2012) Luc Dupuis et al.   Cell Metabolism

PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue

(2012) Toshiya Matsubara et al.   Cell Metabolism

Serum Levels of the Adipokine Progranulin Depend on Renal Function

(2012) J. Richter et al.   DIABETES CARE

XBP1S protects cells from ER stress-induced apoptosis through Erk1/2 signaling pathway involving CHOP

(2012) Feng-Jin Guo et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration

(2012) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

(2012) Atsushi Tanaka et al.   ARTHRITIS RESEARCH & THERAPY

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

(2012) Noritaka Kawasaki et al.   Scientific Reports

Progranulin axis and recent developments in frontotemporal lobar degeneration

(2012) Alexandra M Nicholson et al.   Alzheimers Research & Therapy

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

(2012) Qing-Yun Tian et al.   Jove-Journal of Visualized Experiments

Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle

(2011) Gong Peng et al.   ENDOCRINOLOGY

Involvement of Progranulin in Hypothalamic Glucose Sensing and Feeding Regulation

(2011) Hyun-Kyong Kim et al.   ENDOCRINOLOGY

Characterization of inclusion bodies with cytoprotective properties formed by seipinopathy-linked mutant seipin

(2011) Daisuke Ito et al.   HUMAN MOLECULAR GENETICS

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

Proepithelin Stimulates Growth Plate Chondrogenesis via Nuclear Factor-κB-p65-dependent Mechanisms

(2011) Shufang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

(2011) Paola Bossù et al.   Journal of Neuroinflammation

Progranulin: A growth factor, a novel TNFR ligand and a drug target

(2011) Chuan-ju Liu et al.   PHARMACOLOGY & THERAPEUTICS

Progranulin Resolves Inflammation

(2011) H. Wu et al.   SCIENCE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Insulin-sensitive obesity

(2010) Nora Klöting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis

(2010) Stephan Blüml et al.   ARTHRITIS AND RHEUMATISM

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Adipokine Pattern in Subjects with Impaired Fasting Glucose and Impaired Glucose Tolerance in Comparison to Normal Glucose Tolerance and Diabetes

(2010) Anke Tönjes et al.   PLoS One

TNFα activation of PKCδ, mediated by NFκB and ER stress, cross-talks with the insulin signaling cascade

(2009) Michael W. Greene et al.   CELLULAR SIGNALLING

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

(2008) B.-S. Youn et al.   DIABETES

Blockade of Tumor Necrosis Factor (TNF) Receptor Type 1-Mediated TNF-α Signaling Protected Wistar Rats from Diet-Induced Obesity and Insulin Resistance

(2008) Huifang Liang et al.   ENDOCRINOLOGY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Progranulin locus deletion in frontotemporal dementia

(2007) I. Gijselinck et al.   HUMAN MUTATION