Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS

(2014) G. Keerthivasan et al.   BLOOD

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Overexpression of miR-125a in Myelodysplastic Syndrome CD34+ Cells Modulates NF-κB Activation and Enhances Erythroid Differentiation Arrest

(2014) Irene Gañán-Gómez et al.   PLoS One

Deletion of the NF- B subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

(2013) S. J. Stein et al.   BLOOD

Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome

(2013) Garrett W. Rhyasen et al.   CANCER CELL

Community-acquired infections and their association with myeloid malignancies

(2013) Glen J. Titmarsh et al.   Cancer Epidemiology

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Interleukin-17 enhances the production of interferon-γ and tumour necrosis factor-α by bone marrow T lymphocytes from patients with lower risk myelodysplastic syndromes

(2013) Zheng Zhang et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Differential IRAK signaling in hematologic malignancies

(2013) Garrett W. Rhyasen et al.   EXPERIMENTAL HEMATOLOGY

Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production

(2013) M. Velegraki et al.   HAEMATOLOGICA

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents

(2013) H Yang et al.   LEUKEMIA

Toll-like receptor alterations in myelodysplastic syndrome

(2013) Y Wei et al.   LEUKEMIA

Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells

(2013) Y Wei et al.   LEUKEMIA

Metabolites of tryptophan catabolism are elevated in sera of patients with myelodysplastic syndromes and inhibit hematopoietic progenitor amplification

(2013) Céline Berthon et al.   LEUKEMIA RESEARCH

IL10 inversely correlates with the percentage of CD8+ cells in MDS patients

(2013) Matheus Rodrigues Lopes et al.   LEUKEMIA RESEARCH

Myelodysplastic syndromes and autoimmune diseases—Case series and review of literature

(2013) Omar Al Ustwani et al.   LEUKEMIA RESEARCH

Inflammatory Arthritis in Patients With Myelodysplastic Syndromes

(2013) Arsène Mekinian et al.   MEDICINE

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

(2013) Jing Li et al.   PHARMACOLOGY & THERAPEUTICS

The Different Immunoregulatory Functions on Dendritic Cells between Mesenchymal Stem Cells Derived from Bone Marrow of Patients with Low-Risk or High-Risk Myelodysplastic Syndromes

(2013) Zhenling Wang et al.   PLoS One

Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

(2013) Sophie Dimicoli et al.   PLoS One

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

(2013) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

(2012) L. Barreyro et al.   BLOOD

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1

(2012) J. Fang et al.   BLOOD

Emerging immunosuppressive drugs in myelodysplastic syndromes

(2012) Pearlie K Epling-Burnette et al.   EXPERT OPINION ON EMERGING DRUGS

Expansion of Effector Memory Regulatory T Cells Represents a Novel Prognostic Factor in Lower Risk Myelodysplastic Syndrome

(2012) A. W. Mailloux et al.   JOURNAL OF IMMUNOLOGY

Molecular genetics in myelodysplastic syndromes

(2012) Torsten Haferlach   LEUKEMIA RESEARCH

Noncanonical NF-κB Signaling Regulates Hematopoietic Stem Cell Self-Renewal and Microenvironment Interactions

(2012) Chen Zhao et al.   STEM CELLS

Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells

(2011) Julie R. Boiko et al.   CYTOKINE

Increased cancer risks among arthroplasty patients: 30year follow-up of the Swedish Knee Arthroplasty Register

(2011) Philippe Wagner et al.   EUROPEAN JOURNAL OF CANCER

Chronic Immune Stimulation Might Act As a Trigger for the Development of Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2011) Sigurdur Y. Kristinsson et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Deregulation of microRNAs in myelodysplastic syndrome

(2011) G W Rhyasen et al.   LEUKEMIA

IPSS-independent prognostic value of plasma CXCL10, IL-7 and IL-6 levels in myelodysplastic syndromes

(2011) A Pardanani et al.   LEUKEMIA

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Systemic and immune manifestations in myelodysplasia: A multicenter retrospective study

(2011) A. de Hollanda et al.   ARTHRITIS CARE & RESEARCH

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy

(2010) E. M. Sloand et al.   BLOOD

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia

(2010) S. M. Kornblau et al.   BLOOD

Reduced SMAD7 Leads to Overactivation of TGF-  Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-  Receptor I Kinase

(2010) L. Zhou et al.   CANCER RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia

(2010) Nobuo Kuninaka et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

In vitro deprivation of CD8+CD57+T cells promotes the malignant growth of bone marrow colony cells in patients with lower-risk myelodysplastic syndrome

(2010) Zhang Zheng et al.   EXPERIMENTAL HEMATOLOGY

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes

(2010) X. Feng et al.   HAEMATOLOGICA

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

(2010) A Pellagatti et al.   LEUKEMIA

Risks of myeloid malignancies in patients with autoimmune conditions

(2009) L A Anderson et al.   BRITISH JOURNAL OF CANCER

IL-17-producing CD4+T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome

(2009) Shahram Y. Kordasti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Simultaneous Occurrence of Inflammatory Bowel Disease and Myelodysplastic Syndrome due to Chromosomal Abnormalities in Bone Marrow Cells

(2009) Fumiyasu Nakamura et al.   DIGESTION

Patients with myelodysplastic syndromes display several T-cell expansions, which are mostly polyclonal in the CD4+ subset and oligoclonal in the CD8+ subset

(2009) Claudio Fozza et al.   EXPERIMENTAL HEMATOLOGY

The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate

(2009) K De Luca et al.   LEUKEMIA

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

5q– myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics

(2009) K M Eisenmann et al.   ONCOGENE

Reserves, Functional, Immunoregulatory, and Cytogenetic Properties of Bone Marrow Mesenchymal Stem Cells in Patients with Myelodysplastic Syndromes

(2009) Mirjam Klaus et al.   STEM CELLS AND DEVELOPMENT

High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival

(2008) D. T. Starczynowski et al.   BLOOD

Tumour necrosis factor-induced gene expression in human marrow stroma: clues to the pathophysiology of MDS?

(2008) Derek L. Stirewalt et al.   BRITISH JOURNAL OF HAEMATOLOGY

The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes

(2008) Apostolia Maria Tsimberidou et al.   CANCER

Activation of cytotoxic T-cell receptor    T lymphocytes in response to specific stimulation in myelodysplastic syndromes

(2008) J.-J. Kiladjian et al.   HAEMATOLOGICA

Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)

(2008) I Kotsianidis et al.   LEUKEMIA

Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment

(2008) Tony Navas et al.   LEUKEMIA & LYMPHOMA

Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells

(2008) Eugenia Flores-Figueroa et al.   LEUKEMIA RESEARCH