Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1

Bortezomib combined with low-dose cytarabine in Intermediate-2 and high risk myelodysplastic syndromes. A phase I/II Study by the GFM

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RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

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Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim

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Autophagy and Aging

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Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20

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TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer

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miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

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p53 Independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

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Deregulation of microRNAs in myelodysplastic syndrome

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Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells

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Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy

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NF- B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies

(2011) J. L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations

(2010) D. T. Starczynowski et al.   BLOOD

MicroRNA-146a disrupts hematopoietic differentiation and survival

(2010) Daniel T. Starczynowski et al.   EXPERIMENTAL HEMATOLOGY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

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Effect of Noncompetitive Proteasome Inhibition on Bortezomib Resistance

(2010) Xiaoming Li et al.   JNCI-Journal of the National Cancer Institute

Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis

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Erythroid response and decrease of WT1 expression after proteasome inhibition by bortezomib in myelodysplastic syndromes

(2010) Giuliana Alimena et al.   LEUKEMIA RESEARCH

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Bortezomib induces autophagic death in proliferating human endothelial cells

(2009) Daniela Belloni et al.   EXPERIMENTAL CELL RESEARCH

Characterization of the ubiquitin–proteasome system in bortezomib-adapted cells

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Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells

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Myelodysplastic syndromes

(2008) S. D. Nimer   BLOOD

Molecular basis of bortezomib resistance: proteasome subunit  5 (PSMB5) gene mutation and overexpression of PSMB5 protein

(2008) R. Oerlemans et al.   BLOOD

Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/leukemia cells derived from Jurkat line

(2008) Shuqing Lü et al.   EXPERIMENTAL HEMATOLOGY

The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

(2008) E. Colado et al.   HAEMATOLOGICA

Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6

(2008) Huang Hongming et al.   LEUKEMIA RESEARCH