The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal

Ciliary and Nuclear Transport: Different Places, Similar Routes?

(2012) Samson O. Obado et al.   DEVELOPMENTAL CELL

Identification of a Karyopherin β1/β2 Proline-Tyrosine Nuclear Localization Signal in Huntingtin Protein

(2012) Carly R. Desmond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome

(2012) Kirsty M. Brodie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia

(2012) Hooi Lynn Kee et al.   NATURE CELL BIOLOGY

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

(2012) A. Di Pardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of BARD1 targeting and dynamics at the centrosome: The role of CRM1, BRCA1 and the Q564H mutation

(2011) Kirsty M. Brodie et al.   CELLULAR SIGNALLING

Ran-dependent nuclear export mediators: a structural perspective

(2011) Thomas Güttler et al.   EMBO JOURNAL

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

(2011) Lise Munsie et al.   HUMAN MOLECULAR GENETICS

Localization of retinitis pigmentosa 2 to cilia is regulated by Importin  2

(2011) T. W. Hurd et al.   JOURNAL OF CELL SCIENCE

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

(2011) Guy Keryer et al.   JOURNAL OF CLINICAL INVESTIGATION

Secondary Structures of Native and Pathogenic Huntingtin N-Terminal Fragments

(2011) Maciej Długosz et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Induction of Ran GTP drives ciliogenesis

(2011) Shuling Fan et al.   MOLECULAR BIOLOGY OF THE CELL

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

Silencing Nuclear Pore Protein Tpr Elicits a Senescent-Like Phenotype in Cancer Cells

(2011) Brigitte David-Watine   PLoS One

The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway

(2011) J. H. Coyle et al.   RNA

Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates

(2011) YaPing Yan et al.   Science China-Life Sciences

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

(2010) Thomas Güttler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

(2010) Juliette D. Godin et al.   NEURON

Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr

(2009) Iris Ben-Efraim et al.   BMC CELL BIOLOGY

Phosphorylation of Threonine 3

(2009) Charity T. Aiken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

(2009) Xiaofeng Gu et al.   NEURON

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates

(2008) Lei Wang et al.   EMBO REPORTS

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Nuclear Export Receptor Xpo1/Crm1 Is Physically and Functionally Linked to the Spindle Pole Body in Budding Yeast

(2008) A. Neuber et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatial and temporal coordination of mitosis by Ran GTPase

(2008) Paul R. Clarke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY