Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Relevance of Mitochondrial Genetics and Metabolism in Cancer Development

(2013) G. Gasparre et al.   Cold Spring Harbor Perspectives in Biology

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

(2012) Luísa Pereira et al.   BMC CANCER

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

(2012) Simon M. Schultze et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Universal heteroplasmy of human mitochondrial DNA

(2012) B. A. I. Payne et al.   HUMAN MOLECULAR GENETICS

Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas

(2012) I. Kurelac et al.   HUMAN MOLECULAR GENETICS

Complex I impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes

(2012) Luisa Iommarini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Human mitochondrial DNA: roles of inherited and somatic mutations

(2012) Eric A. Schon et al.   NATURE REVIEWS GENETICS

Spectrum of somatic mitochondrial mutations in five cancers

(2012) T. C. Larman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of idebenone on mitochondrial bioenergetics

(2011) Valentina Giorgio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1, an Oncojanus Function

(2011) G. Gasparre et al.   CANCER RESEARCH

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

(2011) Lokendra Kumar Sharma et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated withEGFRgene mutation

(2011) Santanu Dasgupta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pharmacological targeting of mitochondrial complex I deficiency: The cellular level and beyond

(2011) Peggy Roestenberg et al.   MITOCHONDRION

Genetic insights into OXPHOS defect and its role in cancer

(2010) Dhyan Chandra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

(2009) F. Distelmaier et al.   BRAIN

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

(2009) Jianxin Lu et al.   CELL RESEARCH

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

(2009) Regan M. Memmott et al.   CELLULAR SIGNALLING

Mitochondrial Mutations Contribute to HIF1  Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma

(2009) W. Sun et al.   CLINICAL CANCER RESEARCH

The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization

(2009) Anna Maria Porcelli et al.   HUMAN MOLECULAR GENETICS

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

(2009) J. S. Park et al.   HUMAN MOLECULAR GENETICS

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

(2009) Nobuko Koshikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I

(2008) A. M. Porcelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Respiratory Complex I Dysfunction Due to Mitochondrial DNA Mutations Shifts the Voltage Threshold for Opening of the Permeability Transition Pore toward Resting Levels

(2008) Anna Maria Porcelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE