Article
Immunology
Juan Li, Wei-Te Lei, Peng Zhang, Franck Rapaport, Yoann Seeleuthner, Bingnan Lyu, Takaki Asano, Jeremie Rosain, Boualem Hammadi, Yu Zhang, Simon J. Pelham, Andras N. Spaan, Melanie Migaud, David Hum, Benedetta Bigio, Maya Chrabieh, Vivien Beziat, Jacinta Bustamante, Shen-Ying Zhang, Emmanuelle Jouanguy, Stephanie Boisson-Dupuis, Jamila El Baghdadi, Vishukumar Aimanianda, Katharina Thoma, Manfred Fliegauf, Bodo Grimbacher, Anne-Sophie Korganow, Carol Saunders, V. Koneti Rao, Gulbu Uzel, Alexandra F. Freeman, Steven M. Holland, Helen C. Su, Charlotte Cunningham-Rundles, Claire Fieschi, Laurent Abel, Anne Puel, Aurelie Cobat, Jean-Laurent Casanova, Qian Zhang, Bertrand Boisson
Summary: NFKB1 deficiency is considered the most common genetic cause of common variable immunodeficiency (CVID). This study found that a large proportion of CVID patients have loss of function or hypomorphic NFKB1 variants, while the majority of variants in the general population or patients with unrelated conditions are neutral. The enrichment of deleterious NFKB1 variants in CVID patients is significantly higher than in other populations.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Luzia Bruns, Victoria Panagiota, Sandra von Hardenberg, Gunnar Schmidt, Ignatius Ryan Adriawan, Eleni Sogka, Stefanie Hirsch, Gerrit Ahrenstorf, Torsten Witte, Reinhold Ernst Schmidt, Faranaz Atschekzei, Georgios Sogkas
Summary: This study investigated the prevalence of cancer and associated clinical, immunological, and genetic factors in a German cohort of patients with common variable immunodeficiency (CVID). The results showed that gastric cancer, non-melanoma skin cancer (NMSC), and non-Hodgkin lymphoma (NHL) were the most common types of cancer in CVID patients. Immune dysregulation manifested as arthritis, atrophic gastritis, or interstitial lung disease (ILD) was found to be associated with the diagnosis of cancer. The study concluded that studied immunological parameters or the identification of a monogenic form of CVID have a limited role in evaluating cancer risk in CVID.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Michelle Mota Sena, Kleber Paiva Trugilo, Nadia Calvo Martins Okuyama, Erica Romao Pereira, Fernando Cezar-dos-Santos, Rodolfo Sanches Ferreira, Aline Esposito, Ana Paula Lombardi Pereira, Jose d'oliveira Couto-Filho, Maria Angelica Ehara Watanabe, Karen Brajao de Oliveira
Summary: This study did not observe significant effects of the interaction between NFKB1 rs28362491 and NFKBIA rs696 genetic variants on HPV infection, lesions development, and progression to cervical cancer. Further research is needed to investigate if these genetic variants influence the progression of HPV-associated lesions under certain circumstances.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jie Zhao, Honggang Wang, Jin Zhou, Jun Qian, Haojun Yang, Yan Zhou, Hao Ding, Yu Gong, Xiaoyang Qi, Yuwen Jiao, Pu Ying, Liming Tang, Ye Sun, Weiming Zhu
Summary: The study reveals that miR-130a-3p promotes the progression of Crohn's disease through the ATG16L1/NF-kappa B pathway and serves as a potential preclinical therapeutic target in Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Longyuan Zhou, Liguo Zhu, Xiaomin Wu, Shixian Hu, Shenghong Zhang, Min Ning, Jun Yu, Minhu Chen
Summary: TMIGD1 plays a crucial role in maintaining intestinal barrier integrity and inhibiting inflammation in Crohn's disease, suggesting it as a potential therapeutic target for this condition.
Article
Gastroenterology & Hepatology
Xue-Liang Sun, Li-Chao Qiao, Jing Gong, Ke Wen, Zhi-Zhong Xu, Bo-Lin Yang
Summary: This study identified FGL1 as a potential biomarker and therapeutic target for Crohn's disease (CD) through proteomics analysis. FGL1 was found to be upregulated in plasma and intestinal tissues of CD patients, and was shown to induce intestinal inflammation by activating the canonical NF-kappa B signalling pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Respiratory System
Katja Hoenzke, Benedikt Obermayer, Christin Mache, Diana Fathykova, Mirjana Kessler, Simon Doekel, Emanuel Wyler, Morris Baumgardt, Anna Loewa, Karen Hoffmann, Patrick Graff, Jessica Schulze, Maren Mieth, Katharina Hellwig, Zeynep Demir, Barbara Biere, Linda Brunotte, Angeles Mecate-Zambrano, Judith Bushe, Melanie Dohmen, Christian Hinze, Sefer Elezkurtaj, Mario Toennies, Torsten T. Bauer, Stephan Eggeling, Hong-Linh Tran, Paul Schneider, Jens Neudecker, Jens C. Rueckert, Kai M. Schmidt-Ott, Jonas Busch, Frederick Klauschen, David Horst, Helena Radbruch, Josefine Radke, Frank Heppner, Victor M. Corman, Daniela Niemeyer, Marcel A. Mueller, Christine Goffinet, Ronja Mothes, Anna Pascual-Reguant, Anja Erika Hauser, Dieter Beule, Markus Landthaler, Stephan Ludwig, Norbert Suttorp, Martin Witzenrath, Achim D. Gruber, Christian Drosten, Leif-Erik Sander, Thorsten Wolff, Stefan Hippenstiel, Andreas C. Hocke
Summary: This study reveals that severe lung injury in COVID-19 may result from macrophage-triggered immune activation rather than direct viral damage to the alveolar compartment.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Yumeng Wu, Wei Xiu, Yubo Wu
Summary: SalA can protect H9C2 cells from Dox-induced injury and apoptosis by inhibiting NF-kappa B signaling pathway and expression of apoptotic proteins.
MEDICAL SCIENCE MONITOR
(2021)
Article
Cell Biology
Zhao Liu, Du Meng, Jianling Wang, Hongxin Cao, Peng Feng, Siyu Wu, Na Wang, Chengxue Dang, Peng Hou, Peng Xia
Summary: GASP1 is highly expressed in breast cancer and its knockout inhibits malignant properties of breast cancer cells while improving their response to paclitaxel, indicating its potential as a therapeutic target in breast cancer.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Pedro A. Ruiz Castro, Hasmik Yepiskoposyan, Sylvain Gubian, Florian Calvino-Martin, Ulrike Kogel, Kasper Renggli, Manuel C. Peitsch, Julia Hoeng, Marja Talikka
Summary: The study explores the molecular mechanisms of IBD by constructing three independent biological network models that represent signaling pathways contributing to the disease. These models accurately capture the perturbations in disease states and provide insights into individual drug responses in personalized medicine.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jiang Liu, Liyan Lao, Jianing Chen, Jiang Li, Wenfeng Zeng, Xiaofeng Zhu, Jiaqian Li, Xueman Chen, Linbin Yang, Yue Xing, Fei Chen, Di Huang, Xiaoqian Zhang, Wei Wei, Chang Gong, Shuya Huang, Zhigang Yu, Zhihua Li, Linhan Yang, Jinping Liu, Xiaozhen Liu, Qinghui Zheng, Xuli Meng, Jing Liang, Luyang Sun, Musheng Zeng, Mengfeng Li, Qiang Liu, Shicheng Su, Erwei Song
Summary: Chemotherapy-induced IFN-activated proinflammatory macrophages promote both antitumor immunity and cancer chemoresistance by upregulating IRENA, a long noncoding RNA that triggers pro-tumor inflammatory cytokine production via NF-kappa B signaling. Targeting IRENA can reverse the tumor-promoting inflammation while preserving the ability to enhance antitumor immunity.
Article
Immunology
Daniel G. Camblor, Daniel Miranda, Guillermo M. Albaiceta, Laura Amado-Rodriguez, Elias Cuesta-Llavona, Daniel Vazquez-Coto, Julia Gomez de Ona, Claudia Garcia-Lago, Juan Gomez, Eliecer Coto
Summary: Variants in NF-κB genes may be associated with the risk of developing severe COVID-19, with the NFKBIZ gene significantly affecting mortality.
Article
Medicine, General & Internal
Robert N. Hawthorne, Adriana Blazeski, Justin Lowenthal, Suraj Kannan, Roald Teuben, Deborah DiSilvestre, Justin Morrissette-McAlmon, Jeffrey E. Saffitz, Kenneth R. Boheler, Cynthia A. James, Stephen P. Chelko, Gordon Tomaselli, Leslie Tung
Summary: ARVC is a progressive heart condition linked to pathogenic mutations in the DSG2 gene; using a hiPSC-CM model, it was found that mutant cells exhibit aberrant cytoskeletal organization, increased pro-inflammatory cytokine expression, and electrophysiological changes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Xiangsheng Huang, Wenjing Yang, Suxia Yao, Anthony J. Bilotta, Yao Lu, Zheng Zhou, Pawan Kumar, Sara M. Dann, Yingzi Cong
JOURNAL OF IMMUNOLOGY
(2020)
Review
Immunology
Wenjing Yang, Yingzi Cong
Summary: The gut microbiota and microbiota-derived metabolites play a critical role in maintaining immune homeostasis and are involved in the pathogenesis of various immune-related inflammatory disorders.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li
Summary: The study found that host-derived L-lactate can promote intestinal epithelial cell (IEC) migration by increasing mitochondrial ATP production in IEC, aiding in promoting intestinal wound healing. Additionally, administering mice with L-lactate can suppress colitis induced by dextran sulfate sodium.
Article
Immunology
Yuejin Liang, Xiaofang Wang, Hui Wang, Wenjing Yang, Panpan Yi, Lynn Soong, Yingzi Cong, Jiyang Cai, Xuegong Fan, Jiaren Sun
Summary: IL-33 promotes activation and proliferation of CD8(+) T cells via mTORC1 in LCMV infection.
Article
Immunology
Wenjing Yang, Liang Chen, Leiqi Xu, Anthony J. Bilotta, Suxia Yao, Zhanju Liu, Yingzi Cong
Summary: This study demonstrates the role of miR-10a in regulating IL-10 production in CD4(+) T cells to maintain intestinal homeostasis. The deficiency of miR-10a in CD4(+) T cells led to increased resistance to intestinal inflammation, with increased IL-10 production. Blocking the IL-10/IL-10R pathway exacerbated colitis induced by miR-10a-deficient CD4(+)CD45Rb(hi) T cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
So Imakiire, Hidetoshi Takedatsu, Keiichi Mitsuyama, Hideto Sakisaka, Kozo Tsuruta, Masaru Morita, Nobuaki Kuno, Koichi Abe, Sadahiro Funakoshi, Hideki Ishibashi, Shinichiro Yoshioka, Takuji Torimura, Fumihito Hirai
Summary: This study found that PR3-ANCA measurement is useful for diagnosing UC, evaluating disease severity and extension, and predicting the clinical course.
Article
Gastroenterology & Hepatology
Yi Li, Jianping Chen, Andrew A. Bolinger, Haiying Chen, Zhiqing Liu, Yingzi Cong, Allan R. Brasier, Irina Pinchuk, Bing Tian, Jia Zhou
Summary: Inflammatory bowel disease (IBD) is a serious chronic gastrointestinal disease, with long-term inflammation contributing to neoplastic transformation and colorectal cancer development. The discovery of new small molecule drugs targeting specific pathways in mucosal inflammation offers hope for the treatment of IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, Research & Experimental
Wenjing Yang, Tianming Yu, Yingzi Cong
Summary: CD4(+) T cell metabolic pathways and gut microbiota play important roles in the pathogenesis of autoimmune disorders.
PRECISION CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Masaru Morita, Hidetoshi Takedatsu, Shinichiro Yoshioka, Keiichi Mitsuyama, Kozo Tsuruta, Kotaro Kuwaki, Ken Kato, Ryosuke Yasuda, Tatsuki Mizuochi, Yushiro Yamashita, Takumi Kawaguchi
Summary: The roles and methods of diagnostic colonoscopy in pediatric patients have evolved and adapted in recent years, as demonstrated by a retrospective analysis. The increasing prevalence of inflammatory bowel disease and eosinophilic gastrointestinal disorder emphasizes the importance of colonoscopy in infants and children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Wenjing Yang, Yingzi Cong
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tianming Yu, Wenjing Yang, Suxia Yao, Yanbo Yu, Maki Wakamiya, George Golovko, Yingzi Cong
Summary: The STING pathway regulates intestinal IgA production by maintaining a group of acetate-producing bacteria, which is mediated by GPR43. The role of STING in intestinal IgA response is still not well understood.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Wenjing Yang, Yingzi Cong
Summary: Animal models of colitis have provided important insights into the underlying mechanisms of inflammatory bowel disease (IBD). T cell adoptive transfer models have become a valuable tool in investigating the immunopathogenesis of intestinal inflammation, with CD4(+) T cell responses playing a critical role in the development of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Ramasatyaveni Geesala, Ke Zhang, You-Min Lin, John C. Johnson, Yingzi Cong, Steven Cohn, Xuan-Zheng Shi
Summary: This study found that mechanical stress could induce the expression of Th17-polarizing cytokines in the colon, and exclusive enteral nutrition (EEN) attenuates Th17 immune response by reducing mechanical stress-induced IL-6 in Crohn's-like colitis.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Anthony J. Bilotta, Chunyan Ma, Wenjing Yang, Yanbo Yu, Yu Yu, Xiaojing Zhao, Zheng Zhou, Suxia Yao, Sara M. Dann, Yingzi Cong
Summary: The study revealed that propionate enhances intestinal epithelial cell migration by promoting cell spreading and polarization, leading to increased cell speed and persistence. This effect is mediated by inhibition of class I HDAC, GPR43, and STAT3 signaling. Propionate was also shown to promote cell migration under homeostatic conditions and protect against ulcer formation in experimental colitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Roberta Caruso, Bernard C. Lo, Gabriel Nunez
NATURE REVIEWS IMMUNOLOGY
(2020)