Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment

Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis

(2014) C Chen et al.   BRITISH JOURNAL OF CANCER

Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation

(2014) N. Martinez-Bosch et al.   CANCER RESEARCH

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Clinical relevance of galectin-1 expression in non-small cell lung cancer patients

(2014) María José Carlini et al.   LUNG CANCER

Bevacizumab plus Ipilimumab in Patients with Metastatic Melanoma

(2014) F. S. Hodi et al.   Cancer Immunology Research

Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGFβ1-induced macrophages

(2014) Camila Maria Longo Machado et al.   Cancer Medicine

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

(2013) Xander M. van Wijk et al.   ACS Chemical Biology

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

(2013) Massimo Zucchetti et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity

(2013) Tina Verschuere et al.   INTERNATIONAL JOURNAL OF CANCER

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

VEGFR1 and VEGFR2 Involvement in Extracellular Galectin-1- and Galectin-3-Induced Angiogenesis

(2013) Nicky D'Haene et al.   PLoS One

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

(2013) N. Freitag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease

(2012) T. Dalotto-Moreno et al.   CANCER RESEARCH

A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease

(2012) D. J. Laderach et al.   CANCER RESEARCH

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

(2012) Gabriel A. Rabinovich et al.   IMMUNITY

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma

(2012) Diego O. Croci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes

(2012) Véronique Mathieu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis

(2012) Enza Piccolo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Glycosylation, galectins and cellular signaling

(2011) Cecile Boscher et al.   CURRENT OPINION IN CELL BIOLOGY

Synergistic Induction of Galectin-1 by CCAAT/Enhancer Binding Protein α and Hypoxia-inducible Factor 1α and Its Role in Differentiation of Acute Myeloid Leukemic Cells

(2011) Xu-Yun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 Protein Modulates Cell Surface Expression and Activation of Vascular Endothelial Growth Factor Receptor 2 in Human Endothelial Cells

(2011) Anna I. Markowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Transcriptional regulation of the vascular endothelial glycome by angiogenic and inflammatory signalling

(2010) Martina Willhauck-Fleckenstein et al.   ANGIOGENESIS

HGF/c-Met Acts as an Alternative Angiogenic Pathway in Sunitinib-Resistant Tumors

(2010) F. Shojaei et al.   CANCER RESEARCH

Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity

(2010) V. L. Thijssen et al.   CANCER RESEARCH

Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem-repeat” lectin galectin-8

(2010) Víctor M. Cárdenas Delgado et al.   FASEB JOURNAL

Cleavage of galectin-3 by matrix metalloproteases induces angiogenesis in breast cancer

(2010) Pratima Nangia-Makker et al.   INTERNATIONAL JOURNAL OF CANCER

α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling

(2010) Shinobu Kitazume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability

(2010) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

(2010) Anna I. Markowska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A systematic approach to protein glycosylation analysis: a path through the maze

(2010) Karina Mariño et al.   Nature Chemical Biology

Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited

(2009) Sonja Loges et al.   CANCER CELL

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Regulation of Notch signaling during T- and B-cell development byO-fucose glycans

(2009) Pamela Stanley et al.   IMMUNOLOGICAL REVIEWS

Protein-glycan interactions in the control of innate and adaptive immune responses

(2008) Yvette van Kooyk et al.   NATURE IMMUNOLOGY

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE