Article
Multidisciplinary Sciences
Huanjiao Jenny Zhou, Lingfeng Qin, Quan Jiang, Katie N. Murray, Haifeng Zhang, Busu Li, Qun Lin, Morven Graham, Xinran Liu, Jaime Grutzendler, Wang Min
Summary: The study reveals that mice with brain EC-specific deletion of Pdcd10 develop genuine CCM lesions, allowing visualization of vascular dynamics, and uncovers the mechanisms of CCM initiation and formation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tingting Yin, Sheng Chen, Guohua Zeng, Wanwan Yuan, Yanli Lu, Yanan Zhang, Qianqian Huang, Xiaowei Xiong, Baohua Xu, Qiren Huang
Summary: The knockout of the ASP gene promotes the browning and angiogenesis of white adipose tissue in mice, leading to weight loss in obese mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Ming-Tsai Chiang, I-Ming Chen, Fu-Fei Hsu, Yen-Hui Chen, Min-Shao Tsai, Yaw-Wen Hsu, Hsin-Bang Leu, Po-Hsun Huang, Jaw-Wen Chen, Fu-Tong Liu, Ying-Hwa Chen, Lee-Young Chau
Summary: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease with high mortality in elders, lacking prognostic and therapeutic targets. Gal-1, a lectin expressed in vasculature, has been identified as a key player in the progression of AAA. Experimental and clinical studies suggest that Gal-1 may serve as a potential disease biomarker and therapeutic target for AAA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Yunying Huang, Hana Jedlickova, Yang Cai, Ambreen Rehman, Luke Gammon, Usama Sharif Ahmad, Jutamas Uttagomol, Eric Kenneth Parkinson, Farida Fortune, Hong Wan
Summary: Pemphigus Vulgaris (PV) is a life-threatening autoimmune disease characterized by blisters in the skin and mucosa, with oxidative stress and YAP dysregulation playing crucial roles in its pathogenesis. Antioxidants may be beneficial in the treatment of PV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kei Hashimoto, Yuko Miyagawa, Saya Watanabe, Kazuki Takasaki, Miki Nishizawa, Keita Yatsuki, Yuko Takahashi, Hideo Kamata, Chikara Kihira, Haruko Hiraike, Yukifumi Sasamori, Koichiro Kido, Eiji Ryo, Kazunori Nagasaka
Summary: Placenta accreta is a high-risk condition causing obstetric crisis and hemorrhage, and its pathogenesis is not yet fully understood. This study identified the potential factors involved in trophoblast invasiveness and angiogenic potential that contribute to the development of placenta accreta. The study focused on the TGF-beta 1-Smad pathway and investigated the inhibitory effect of UCHL5 using bAP15 on trophoblast cells. The results suggest that the interaction between TGF-beta 1-Smad and ERK pathways is involved in the abnormal invasive and angiogenic capacities of extravillous cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ruijing Chang, Yuan Su, Hongfang Kong, Fang Wang, Ying Xing, Lei Jiang, Hong Xin
Summary: This study indicates that disturbance of SEMP1 expression is associated with preeclampsia. SEMP1 levels were found to be downregulated in placental tissues of PE patients. Overexpression of SEMP1 enhanced the capability of trophoblast cells in proliferation, migration, and invasion.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chaozhi Bu, Zhiwei Wang, Yongwei Ren, Daozhen Chen, Shi-Wen Jiang
Summary: This review examines the relationship between inflammation, nonfusogenic functions of syncytin-1, and the development of preeclampsia. The reciprocal modulations of inflammation and poor vascularization/hypoxia are discussed, as well as the significance of syncytin-1 expression in immune cells for inflammation. The review also compares the involvement of syncytin-1 nonfusogenic activities in neuroinflammation and multiple sclerosis with findings from preeclampsia.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yijie Gao, Mengdan Shi, Min Liu, Lingyun Liao, Xiaohong Wei, Yangxue Yin, Rong Zhou
Summary: This study investigated the biological function and mechanism of miR-95-3p in preeclampsia (PE). The results revealed that miR-95-3p was expressed at low levels in PE placental tissue and negatively correlated with EPM2A expression. Upregulation of miR-95-3p and downregulation of EPM2A promoted trophoblast migration and invasion, and both miR-95-3p and EPM2A regulated the expression of angiogenesis-related factors and inflammation-related factors.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Cell Biology
Tsung-Lin Cheng, Chung-Hwan Chen, Meng-Hsing Wu, Chao-Han Lai, Ko-Hung Lee, Sheng-Hsiang Lin, Ai-Li Shiau, Chao-Liang Wu, Lin Kang
Summary: The study found that levels of FGL1 protein in serum and placenta were significantly upregulated in patients and mice with PE. FGL1 treatment decreased maternal hypertension and proteinuria, decreased fetal weight in PE mice, downregulated proinflammatory cytokine levels, and maintained the balance between antiangiogenic and proangiogenic substances in the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Summary: Type 1 diabetes is an autoimmune disease that affects children. It is challenging to study in humans due to the difficulty in biopsy and early stage activity. The NOD mouse model provides an opportunity to understand the molecular mechanisms of the disease. IFN-γ plays a role in inflammation and autoreactive T cell proliferation, but inhibiting it may not be an effective therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Article
Medicine, General & Internal
Huifang Lian, XiaoLong Fang, Qingyu Li, Shuang Liu, Qiuhong Wei, Xia Hua, Wenguang Li, Chunyang Liao, Xiaoyong Yuan
Summary: This study revealed the involvement of NLRP3 inflammasome activation and pyroptosis in C. albicans-infected mouse corneas and HCECs. The NLRP3 inflammasome-mediated pyroptosis signaling contributes to the severity of C. albicans keratitis. Targeting this NLRP3 inflammasome-dependent pathway may provide a potential treatment strategy for fungal keratitis.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Le-le Liu, Yu Han, Zi-jia Zhang, Yi-qi Wang, Yu-wei Hu, Elena Kaznacheyeva, Jian-qing Ding, Dong-kai Guo, Guang-hui Wang, Bin Li, Hai-gang Ren
Summary: Parkinson's disease is a neurodegenerative motor disorder characterized by reduced dopamine levels. The loss of DJ-1 function leads to increased expression of MAO-B, which is associated with dopamine degradation, oxidative stress, and mitochondrial dysfunction. This study reveals the mechanistic link between DJ-1 and MAO-B expression and contributes to understanding the pathogenesis of Parkinson's disease.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Reproductive Biology
Zheng Wang, Gongxiao Zhao, Ming Zeng, Weiyi Feng, Jinjun Liu
Summary: EVs play a significant role in the pathogenesis of preeclampsia and can serve as biomarkers for early screening of PE. Studies have shown that the bioactive cargos carried by EVs are associated with the development of PE, and further understanding of the contribution of EVs to PE can lead to new clinical strategies for managing the disorder.
BIOLOGY OF REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Som Dev, Abigael Muchenditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L. Gabrielson, Yixuan Dong, Robert Hughes, Norman J. Haughey, James P. Hamilton, Svetlana Lutsenko
Summary: This study identified an important regulatory pathway in Wilson disease with copper metabolism abnormalities, which can improve liver damage and restore function.
Article
Peripheral Vascular Disease
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Andreas Busjahn, Anna Birukov, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Kristin Kraeker, Michaela Golic
Summary: A study conducted on a rat model found that maternal diabetes during pregnancy without obesity did not have a negative impact on the metabolic health of male offspring. There were no significant differences in blood glucose control between offspring exposed to maternal hyperglycemia and those from control pregnancies. Intrauterine exposure to hyperglycemia and hyperinsulinemia without obesity did not lead to fetal programming of diabetes and obesity in this particular model.
Article
Multidisciplinary Sciences
Annemiek Dickhout, Bibian M. E. Tullemans, Johan W. M. Heemskerk, Victor L. J. L. Thijssen, Marijke J. E. Kuijpers, Rory R. Koenen
Summary: This study showed that gal-1 and CXCL4 colocalize on the platelet surface and co-activation of platelets by both can enhance aggregation. Their individual effects on platelets exhibit distinct and complementary activation profiles, with additive rather than synergistic effects.
Article
Immunology
Kirstin Faust, Nancy Freitag, Gabriela Barrientos, Christoph Hartel, Sandra M. Blois
Summary: This study found that galectin-1, -3, and -9 levels are elevated in preterm infants born in an inflammatory environment, such as amniotic infection syndrome (AIS) or early-onset sepsis (EOS). Galectin-1 levels were notably increased in infants born to AIS, and levels of galectin-3 were higher in infants who developed EOS compared to unaffected infants. These findings suggest a potential role for galectins in mediating inflammation-induced preterm birth and could be a target for future clinical trials.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah M. Kedziora, Kristin Kraker, Lajos Marko, Julia Binder, Meryam Sugulle, Martin Gauster, Dominik N. Muller, Ralf Dechend, Nadine Haase, Florian Herse
Summary: Preeclampsia is associated with renal injuries during pregnancy, but most of these pathologies often recover postpartum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Nancy Freitag, Yiran Xie, Lisa-Marie Adam, Sophia Borowski, Sandra M. Blois, Gabriela Barrientos
Summary: The study revealed the important role of alternative splicing regulator Rbfox2 in modulating trophoblast function during placental development, with implications for the pathogenesis of conditions like preeclampsia in pregnancy.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Michaela Golic, Kristin Kraeker
Summary: Research revealed that diabetic pregnancy affects the cardiac health of rat offspring, particularly under high-fat diet conditions. Offspring of diabetic pregnancies showed cardiac dysfunction and changes in cardiomyocytes after consuming a high-fat diet, highlighting the importance of diet in the development of heart dysfunction in offspring of diabetic pregnancies.
Article
Biochemistry & Molecular Biology
Talita Guerreiro Rodrigues Hungaro, Marcos F. Gregnani, Thais Alves-Silva, Florian Herse, Natalia Alenina, Michael Bader, Ronaldo C. Araujo
Summary: During pregnancy, changes in cortisol levels can have significant effects on trophoblastic cells and the development of the embryo. Continuous and intermittent exposure to cortisol both repressed the expression of inflammatory genes, but only continuous exposure repressed the expression of angiogenic genes, indicating that sustained increase in cortisol levels may be more harmful than short-term increases.
Article
Oncology
Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J. M. Huijbers, Danielle R. J. Verboogen, Matthias Reichel, Victor L. Thijssen, Arjan W. Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson
Summary: Galectin-1 (Gal1) is a glycan-binding protein that promotes tumor progression through various mechanisms. Vaccination against Gal1 can generate high anti-Gal1 antibody levels and significantly impairs the growth of Gal1-expressing melanomas in mice. This is associated with improved tumor vasculature perfusion and increased infiltration of macrophages and cytotoxic T cells. Gal1 vaccination is a promising approach to enhance immunotherapeutic strategies for cancer therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Correction
Oncology
Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J. M. Huijbers, Danielle R. J. Verboogen, Matthias Reichel, Victor L. Thijssen, Arjan W. Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Chemistry, Medicinal
I. H. Bartelink, E. A. van de Stadt, A. F. Leeuwerik, V. L. J. L. Thijssen, J. R. Hupsel, J. F. van den Nieuwendijk, I Bahce, M. Yaqub, N. H. Hendrikse
Summary: The developed physiological pharmacokinetic (PBPK) models accurately predicted the image quality and contrast of EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer. These models provide the potential for predicting the image quality of new tracers in the future.
Article
Biochemistry & Molecular Biology
Lionel Mendes Dias, Mark J. de Keijzer, Daniel Ernst, Farangis Sharifi, Daniel J. de Klerk, Tony G. Kleijn, Emilie Desclos, Jakub A. Kochan, Lianne R. de Haan, Leonardo P. Franchi, Albert C. van Wijk, Enzo M. Scutigliani, Marcel H. Fens, Arjan D. Barendrecht, Jose E. B. Cavaco, Xuan Huang, Ying Xu, Weiwei Pan, Marjo J. den Broeder, Jan Bogerd, Rudiger W. Schulz, Kitty C. Castricum, Victor L. Thijssen, Shuqun Cheng, Baoyue Ding, Przemek M. Krawczyk, Michal Heger
Summary: The study developed a comprehensive tumor targeting and photosensitizer delivery platform. It was found that photodynamically active PSs effectively photosensitized cancer cells and non-cancerous cells without notable systemic toxicity. ZnPC and AlPC delivered by ITLs demonstrated strong tumor-killing capacity in human breast cancer xenografts.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lucia Sanjurjo, Esmee C. Broekhuizen, Rory R. Koenen, Victor L. J. L. Thijssen
Summary: Galectins, a family of glycan-binding proteins, play a role in shaping the immune microenvironment by directly affecting immune cell activity and survival, as well as indirectly affecting immune response through binding to cytokines. Galectin-cytokine heterodimers, known as galectokines, add complexity to immune homeostasis regulation. This article summarizes current knowledge on galectokine formation and function, describes mechanisms by which galectokines shape the immune microenvironment, and discusses outstanding questions and challenges for future research on the role of galectokines in immunomodulation.
Article
Biochemistry & Molecular Biology
Sarah M. Kedziora, Benedikt Obermayer, Meryam Sugulle, Florian Herse, Kristin Kraeker, Nadine Haase, Immaculate M. Langmia, Dominik N. Muller, Anne Cathrine Staff, Dieter Beule, Ralf Dechend
Summary: The placenta is a temporary organ with a unique structure and function to ensure healthy fetal development. Placental dysfunction caused by diabetes affects placental metabolism, inflammation, and weight, but the main driver of gene expression differences in the placenta is fetal sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Tesfay M. Godefa, Sarah Derks, Victor L. J. L. Thijssen
Summary: Esophageal cancer is a disease with poor overall survival. Galectins, a family of glycan-binding proteins, have been linked to tumor angiogenesis and immunosuppression and identified as diagnostic and prognostic markers in several cancer types. However, their role in esophageal cancer is still poorly understood. This literature review summarizes the expression and potential functions of galectins in esophageal cancer and highlights the gaps in current knowledge. Further research is needed to better understand the diagnostic, prognostic, and predictive value of galectins in esophageal cancer and their functional role in tumor progression.
Article
Oncology
Charlotte Stroes, Sandor Schokker, Mohammed Khurshed, Stephanie O. van der Woude, Ron A. A. Mathot, Marije Slingerland, Judith de Vos-Geelen, Massimo Zucchetti, Cristina Matteo, Erik van Dijk, Bauke Ylstra, Victor Thijssen, Sarah Derks, Tesfay Godefa, Willemieke Dijksterhuis, Gerben E. Breimer, Otto M. van Delden, Rob H. A. Verhoeven, Sybren L. Meijer, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven
Summary: The study evaluated the tolerability and efficacy of regorafenib and paclitaxel combination therapy in patients with advanced esophagogastric cancer refractory to first-line treatment. The results showed promising potential of this combination therapy in improving patient survival rates, while identifying potential negative predictive biomarkers for treatment response.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)