Article
Zoology
Daniel Hending, Heriniaina Randrianarison, Niaina Nirina Mahefa Andriamavosoloarisoa, Christina Ranohatra-Hending, James Sedera Solofondranohatra, Haja Roger Tongasoa, Daniel Hending, Heriniaina Randrianarison, Niaina Nirina Mahefa Andriamavosoloarisoa, Christina Ranohatra-Hending, James Sedera Solofondranohatra, Haja Roger Tongasoa, Herinirina Tahina Ranarison, Victoria Gehrke, Natacha Andrianirina, Marc Holderied, Grainne McCabe, Sam Cotton
Summary: The encounter rates of dwarf lemurs in northwest Madagascar vary between wet and dry seasons, with higher rates during the wet season and lower rates from May to August. These findings provide some insight into the hibernation patterns of dwarf lemurs in Sahamalaza-Iles Radama National Park.
INTERNATIONAL JOURNAL OF PRIMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray, Andreas Keller
Summary: By studying the expression of noncoding RNA (ncRNA) in aging and rejuvenated mice, we found that the molecular aging trajectories are mostly tissue-specific, except for eight broadly deregulated microRNAs (miRNAs). These miRNAs were also found in circulating plasma and extracellular vesicles (EVs), while tissue-specific ncRNAs were less present. MiR-29c-3p had the strongest correlation with aging in solid organs, plasma, and EVs. In mice rejuvenated by heterochronic parabiosis, the level of miR-29c-3p was restored to a similar level as in young liver. MiR-29c-3p targets pathways related to the extracellular matrix and secretion, which are known to be involved in aging.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jamie L. Endicott, Paula A. Nolte, Hui Shen, Peter W. Laird
Summary: Researchers have provided experimental evidence showing that DNA methylation loss is directly driven by cell division, occurring in aging tissues and worsening in cancer. Blocking DNA replication can halt methylation loss. Ambient oxygen culture conditions increase the rate of methylation loss.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Evan G. Williams, Niklas Pfister, Suheeta Roy, Cyril Statzer, Jack Haverty, Jesse Ingels, Casey Bohl, Moaraj Hasan, Jelena Cuklina, Peter Buhlmann, Nicola Zamboni, Lu Lu, Collin Y. Ewald, Robert W. Williams, Ruedi Aebersold
Summary: We analyzed the liver transcriptome, proteome, and metabolome of BXD mice to study the effects of diet and aging on molecular variations and metabolic traits. We identified genes associated with longevity and found common diet-related candidate genes across datasets. Our study provides insights into causal connections between diet, aging, and metabolic traits.
Article
Zoology
Ute Radespiel, Romule Rakotondravony, Solofonirina Rasoloharijaona, Blanchard Randrianambinina
Summary: Seasonal reproduction differs between the two mouse lemur species, with M. murinus showing high reproductive synchrony and production of two successive litters, while M. ravelobensis exhibits more flexible reproductive seasonality, particularly in years with more rainfall. This suggests adaptive reproductive plasticity in M. ravelobensis to respond flexibly to environmental changes and expand the reproductive period under favorable conditions.
INTERNATIONAL JOURNAL OF PRIMATOLOGY
(2022)
Article
Neurosciences
Wen-Jiao Xue, Cheng-Feng He, Ren-Yuan Zhou, Xiao-Die Xu, Lv-Xuan Xiang, Jian-Tao Wang, Xin-Ru Wang, Hou-Guang Zhou, Jing-Chun Guo
Summary: The study found that high glucose and palmitic acid can induce neuronal senescence through the upregulation of NRSF/REST and reduction of mTOR-autophagy.
Article
Plant Sciences
Tereza Maskova, Tomas Herben, Kristyna Hoskova, Tomas Koubek
Summary: This study explores the patterns and drivers of shoot senescence in perennial herbaceous plants. The research finds that there are significant variations in the pace, shape, and synchrony of senescence trajectories among different species, and these variations are associated with leaf- and shoot-level traits. The study also reveals different senescence patterns among species from different habitats.
JOURNAL OF ECOLOGY
(2022)
Article
Plant Sciences
Cade N. Kane, Scott A. M. McAdam
Summary: Increases in leaf ABA levels do not drive natural leaf senescence in autumn, but can enhance senescence rates. The importance of ABA as a driver of leaf senescence in winter deciduous trees is investigated, and it is found that ABA may augment leaf senescence but is not essential for this annual process.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Cell Biology
Alam Khan, Talukdar Mohammad Fahad, Tanjima Akther, Tanjeena Zaman, Md Faruk Hasan, Md Rafiqual Islam Khan, Mohammad Saiful Islam, Shuji Kishi
Summary: Carbofuran exposure synergistically accelerates cellular senescence and affects biological ageing in spns1 defective animals, as shown by accelerated yolk opaqueness, premature ageing phenotype, and shortened life span.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Fu-Hui Xiao, Qin Yu, Zhi-Li Deng, Ke Yang, Yunshuang Ye, Ming-Xia Ge, Dongjing Yan, Hao-Tian Wang, Xiao-Qiong Chen, Li-Qin Yang, Bin-Yu Yang, Rong Lin, Wen Zhang, Xing-Li Yang, Lei Dong, Yonghan He, Jumin Zhou, Wang-Wei Cai, Ji Li, Qing-Peng Kong
Summary: Through transcriptome analysis of long-lived individuals, it was found that the ribosome pathway is significantly down-regulated, likely controlled by the transcription factor ETS1, which can regulate the expression of ribosomal protein genes to reduce cellular senescence.
Review
Endocrinology & Metabolism
Christopher D. Wiley, Judith Campisi
Summary: Cellular senescence involves a permanent proliferative arrest and the release of biologically active molecules known as SASP. Studies show that senescence and SASP are sensitive to metabolic states, potentially driving phenotypes associated with metabolic dysfunction. Effective interventions may disrupt the feedback loop in which cellular senescence promotes metabolic diseases.
Article
Cell Biology
Sylwia Kabacik, Donna Lowe, Leonie Fransen, Martin Leonard, Siew-Lan Ang, Christopher Whiteman, Sarah Corsi, Howard Cohen, Sarah Felton, Radhika Bali, Steve Horvath, Ken Raj
Summary: Epigenetic clocks are age estimators based on methylation values at specific CpGs in the genome. This study investigates the relationship between epigenetic aging and the previously identified aging hallmarks, and finds associations with nutrient sensing, mitochondrial activity, and stem cell composition.
Article
Surgery
Claire E. Stewart, Adam P. Sharples
Summary: We are living in an aging society, where the elderly population is rapidly growing. Understanding the mechanisms of aging and developing interventions is crucial for improving healthy living. Muscle wasting with aging, known as sarcopenia, can potentially be reversed or delayed through exercise and its underlying mechanisms. Additionally, treatments such as Botox and gene editing hold potential for plastic surgeons in combating facial aging in the future.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Multidisciplinary Sciences
Beth A. Reinke, Hugo Cayuela, Fredric J. Janzen, Jean-Francois Lemaitre, Jean-Michel Gaillard, A. Michelle Lawing, John B. Iverson, Ditte G. Christiansen, Inigo Martinez-Solano, Gregorio Sanchez-Montes, Jorge Gutierrez-Rodriguez, Francis L. Rose, Nicola Nelson, Susan Keall, Alain J. Crivelli, Theodoros Nazirides, Annegret Grimm-Seyfarth, Klaus Henle, Emiliano Mori, Gaetan Guiller, Rebecca Homan, Anthony Olivier, Erin Muths, Blake R. Hossack, Xavier Bonnet, David S. Pilliod, Marieke Lettink, Tony Whitaker, Benedikt R. Schmidt, Michael G. Gardner, Marc Cheylan, Francoise Poitevin, Ana Golubovic, Ljiljana Tomovic, Dragan Arsovski, Richard A. Griffiths, Jan W. Arntzen, Jean-Pierre Baron, Jean-Francois Le Galliard, Thomas Tully, Luca Luiselli, Massimo Capula, Lorenzo Rugiero, Rebecca McCaffery, Lisa A. Eby, Venetia Briggs-Gonzalez, Frank Mazzotti, David Pearson, Brad A. Lambert, David M. Green, Nathalie Jreidini, Claudio Angelini, Graham Pyke, Jean-Marc Thirion, Pierre Joly, Jean-Paul Lena, Anton D. Tucker, Col Limpus, Pauline Priol, Aurelien Besnard, Pauline Bernard, Kristin Stanford, Richard King, Justin Garwood, Jaime Bosch, Franco L. Souza, Jaime Bertoluci, Shirley Famelli, Kurt Grossenbacher, Omar Lenzi, Kathleen Matthews, Sylvain Boitaud, Deanna H. Olson, Tim S. Jessop, Graeme R. Gillespie, Jean Clobert, Murielle Richard, Andres Valenzuela-Sanchez, Gary M. Fellers, Patrick M. Kleeman, Brian J. Halstead, Evan H. Campbell Grant, Phillip G. Byrne, Thierry Fretey, Bernard Le Garff, Pauline Levionnois, John C. Maerz, Julian Pichenot, Kurtulus Olgun, Nazan Uzum, Aziz Avci, Claude Miaud, Johan Elmberg, Gregory P. Brown, Richard Shine, Nathan F. Bendik, Lisa O'Donnell, Courtney L. Davis, Michael J. Lannoo, Rochelle M. Stiles, Robert M. Cox, Aaron M. Reedy, Daniel A. Warner, Eric Bonnaire, Kristine Grayson, Roberto Ramos-Targarona, Eyup Baskale, David Munoz, John Measey, F. Andre de Villiers, Will Selman, Victor Ronget, Anne M. Bronikowski, David A. W. Miller
Summary: This study investigates the aging rates and longevity of wild ectothermic tetrapods, showing that they exhibit higher diversity of aging rates compared to endotherms and provide evidence of negligible aging. Protective phenotypes and life-history strategies explain the macroevolutionary patterns of aging.
Editorial Material
Behavioral Sciences
Daniel Hending, Heriniaina Randrianarison, Sam Cotton, Marc Holderied, Grainne McCabe
Summary: The study found that the northern giant mouse lemur may engage in activities both during the day and night, suggesting a high degree of flexibility in their activity patterns, which is crucial for understanding the evolution of this species.