Article
Cell Biology
Yuan-Xiang Lan, Ping Yang, Zhong Zeng, Neeraj Yadav, Li-Jian Zhang, Li-Bin Wang, He-Chun Xia
Summary: In this study, the gene and protein expression profiles of olfactory ensheathing cells (OECs) derived from the olfactory bulb (OB) and the olfactory mucosa (OM) were compared. The results showed differential expression of genes and proteins between OB-derived OECs and OM-derived OECs, which may explain their different therapeutic roles.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Chun-Gu Hong, Meng-Lu Chen, Ran Duan, Xin Wang, Zhi-Lin Pang, Li-Te Ge, Ming Lu, Hui Xie, Zheng-Zhao Liu
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that is currently incurable. Transplantation of olfactory mucosa mesenchymal stem cells (OM-MSCs) can alleviate symptoms of AD, promote amyloid-beta clearance, and improve cognitive learning and locomotive behavior.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Justina Prada, Isabel Pires, Giulia Ronchi, Stefania Raimondo, Ana L. Luis, Stefano Geuna, Artur Severo P. Varejao, Ana Colette Mauricio
Summary: Cell secretome is of great interest in Regenerative Medicine. This study analyzed the secretome collected from Olfactory Mucosa Mesenchymal Stem Cells and Olfactory Ensheathing Cells and applied it to promote peripheral nerve regeneration. The results showed that this therapeutic combination had beneficial effects on nerve and muscle regeneration, but further research is needed to address irregularities in the outcomes.
Article
Biotechnology & Applied Microbiology
Lite Ge, Chengfeng Xun, Wenshui Li, Shengyu Jin, Zuo Liu, Yi Zhuo, Da Duan, Zhiping Hu, Ping Chen, Ming Lu
Summary: The study revealed that EVs from hypoxic OM-MSCs can enhance angiogenesis through the miR-612-TP53-HIF-1α-VEGF axis, suggesting a promising therapeutic strategy for ischemic diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Irina Amorim, Rui Magalhaes, Filipa Joao, Diogo Almeida, Sandra Amado, Justina Prada, Isabel Pires, Federica Zen, Stefania Raimondo, Ana L. Luis, Stefano Geuna, Artur S. P. Varejao, Ana C. Mauricio
Summary: This study applied chitosan nerve guide conduits and olfactory mucosa mesenchymal stem/stromal cells in treating sciatic nerve regeneration after injury, showing improvements in motor performance, nociception, and nerve regeneration. These therapeutic combinations demonstrate promising outcomes for future research in peripheral nerve treatment.
STEM CELLS INTERNATIONAL
(2021)
Article
Cell & Tissue Engineering
Zheng-Zhao Liu, Yan Huang, Chun-Gu Hong, Xin Wang, Ran Duan, Jian-Yang Liu, Jia-Lin He, Da Duan, Hui Xie, Ming Lu
Summary: This study investigates whether olfactory mucosa mesenchymal stem cells (OM-MSCs) are a promising alternative source for treating refractory epilepsy clinically and uncovers the mechanism by which OM-MSCs administration improves epileptic mouse models. The results show that OM-MSCs recruit Treg cells, inhibit inflammation, rebuild the neural network, and improve cognitive, locomotive, and perceptive functions of epileptic mice, suggesting OM-MSC treatment as a future therapeutic candidate for epilepsy.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Aida V. Garcia Corrales, Mansour Haidar, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Summary: Fatty acids play a crucial role in brain homeostasis and neural function, with glia cells supporting the high demand of FAs in the CNS. Modulating FA synthesis in glia presents a potential therapeutic opportunity for various CNS diseases, including Alzheimer's and multiple sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gaenger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Voelk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowski
Summary: This study validated a refined technique for region-specific drug delivery to the olfactory mucosa in mice, demonstrating improved brain targeting and reduced peripheral targeting. The potential clinical implications of these findings were discussed in the context of intranasal drug delivery to the CNS.
Article
Multidisciplinary Sciences
Fumito Endo, Atsushi Kasai, Joselyn S. Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, Baljit S. Khakh
Summary: This study provides comprehensive molecular data on the diversity and mechanisms of astrocytes in the central nervous system, highlighting the role of certain genes in astrocyte morphology and their association with diseases such as Alzheimer's.
Article
Cell Biology
Vincent Pernet, Sandrine Joly, Sebastian Spiegel, Ivo Meli, Sherif Idriss, Frank Maigler, Julius Baya Mdzomba, Anna K. Roenneke, Alessandra Franceschini, Ludovico Silvestri, Francesco S. Pavone, Martino Calamai, Katharina Schindowski, Andrew Chan
Summary: This study shows that intranasal administration of Nogo-A-blocking antibody through the olfactory mucosa can bypass the blood-brain barrier and improve symptoms in EAE mice. The antibody distributes widely in the central nervous system, inhibits Nogo-A signaling, and improves motor symptoms and myelin preservation in the spinal cord.
CELL DEATH DISCOVERY
(2023)
Article
Neurosciences
Sara Simorgh, Rafieh Alizadeh, Ronk Shabani, Fariba Karimzadeh, Elham Seidkhani, Jamal Majidpoor, Fatemeh Moradi, Hamidreza Kasbiyan
Summary: Delivery of olfactory ectomesenchymal stem cells through intranasal route shows promising results in improving behavioral functions in the animal models of Parkinson's disease.
NEUROTOXICITY RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Lihua Luo, Qunyan Zhu, Yejian Li, Fengting Hu, Jiangtao Yu, Xiangyan Liao, Zhenjie Xing, Yan He, Qingsong Ye
Summary: This study showed that in situ injection of PF127 hydrogel encapsulating dental pulp stem cells into the injured sites could promote the repair and regeneration of fallopian tube injury, providing an attractive strategy for future clinical treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jialin He, Yan Huang, Jianyang Liu, Lite Ge, Xiangqi Tang, Ming Lu, Zhiping Hu
Summary: In hypoxic conditions, human OM-MSCs showed significant differences in the expression of 1741 lncRNAs and 1603 mRNAs. Bioinformatics analysis revealed that genes of OM-MSCs mainly participated in cell cycle regulation and cytokine secretion. Hypoxia promoted proliferation and inhibited apoptosis of OM-MSCs, with lncRNA DARS-AS1 involved in this regulatory process as confirmed by loss-of-function assays.
Article
Chemistry, Physical
Sara Simorgh, Peiman Brouki Milan, Maryam Saadatmand, Zohreh Bagher, Mazaher Gholipourmalekabadi, Rafieh Alizadeh, Ahmad Hivechi, Zohreh Arabpour, Masoud Hamidi, Cedric Delattre
Summary: In this study, human olfactory ectomesenchymal stem cells were encapsulated in a collagen hydrogel system and their osteogenic potential was evaluated in vitro and in vivo conditions. The results indicated that the optimal concentration of collagen hydrogel supported high osteogenic differentiation of the stem cells, leading to enhanced bone healing in vivo. These findings suggest that stem cells with suitable carriers could be a promising approach to address clinical bone complications.
Article
Neurosciences
Sara Simorgh, Zohreh Bagher, Mohammad Farhadi, Seyed Kamran Kamrava, Mahdi Eskandarian Boroujeni, Zeinab Namjoo, Farshid Qiyami Hour, Salah Moradi, Rafieh Alizadeh
Summary: This study investigated the use of a magnetically targeted cell delivery (MTCD) approach for intranasal administration of olfactory ectomesenchymal stem cells (OE-MSCs) in rat models of Parkinson's disease (PD). The results demonstrated that this novel approach enhanced the therapeutic effects of stem cells in improving motor dysfunction associated with PD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Robert P. Ganley, Noboru Iwagaki, Patricia del Rio, Najma Baseer, Allen C. Dickie, Kieran A. Boyle, Erika Polgar, Masahiko Watanabe, Victoria E. Abraira, Amanda Zimmerman, John S. Riddell, Andrew J. Todd
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Paul O'Neill, Susan L. Lindsay, Andreea Pantiru, Scott E. Guimond, Nitish Fagoe, Joost Verhaagen, Jeremy E. Turnbull, John S. Riddell, Susan C. Barnett
Article
Anesthesiology
Noboru Iwagaki, Robert P. Ganley, Allen C. Dickie, Erika Polgar, David I. Hughes, Patricia Del Rio, Yulia Revina, Masahiko Watanabe, Andrew J. Todd, John S. Riddell
Review
Clinical Neurology
C. H. Hulme, S. J. Brown, H. R. Fuller, J. Riddell, A. Osman, J. Chowdhury, N. Kumar, W. E. Johnson, K. T. Wright
Article
Neurosciences
Susan L. Lindsay, Andrew Toft, Jacob Griffin, Ahmed M. M. Emraja, Susan Carol Barnett, John S. Riddell
Article
Neurosciences
Jing Huang, Erika Polgar, Hans Jurgen Solinski, Santosh K. Mishra, Pang-Yen Tseng, Noboru Iwagaki, Kieran A. Boyle, Allen C. Dickie, Mette C. Kriegbaum, Hendrik Wildner, Hanns Ulrich Zeilhofer, Masahiko Watanabe, John S. Riddell, Andrew J. Todd, Mark A. Hoon
NATURE NEUROSCIENCE
(2018)
Article
Neurosciences
Andrew Toft, Mercedes Tome, Susan C. Barnett, John S. Riddell
Article
Neurosciences
Toshiharu Yasaka, David I. Hughes, Erika Polgar, Gergely G. Nagy, Masahiko Watanabe, John S. Riddell, Andrew J. Todd
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Andrew Toft, Mercedes Tome, Susan L. Lindsay, Susan C. Barnett, John S. Riddell
JOURNAL OF NEUROSCIENCE RESEARCH
(2012)
Article
Neurosciences
Noboru Iwagaki, Francesca Garzillo, Erika Polgar, John S. Riddell, Andrew J. Todd
Article
Neurosciences
Toshiharu Yasaka, Sheena Y. X. Tiong, Erika Polgar, Masahiko Watanabe, Eiichi Kumamoto, John S. Riddell, Andrew J. Todd
Article
Anesthesiology
Toshiharu Yasaka, Sheena Y. X. Tiong, David I. Hughes, John S. Riddell, Andrew J. Todd
Article
Multidisciplinary Sciences
Kamal K. E. Gadalla, Paul D. Ross, John S. Riddell, Mark E. S. Bailey, Stuart R. Cobb
Article
Cell & Tissue Engineering
Mercedes Tome, Susan L. Lindsay, John S. Riddell, Susan C. Barnett