Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Function and therapeutic value of astrocytes in neurological diseases

(2022) Hong-Gyun Lee et al.   NATURE REVIEWS DRUG DISCOVERY

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

(2022) Zoeb Jiwaji et al.   Nature Communications

Behaviorally consequential astrocytic regulation of neural circuits

(2021) Jun Nagai et al.   NEURON

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

HepaCAM controls astrocyte self-organization and coupling

(2021) Katherine T. Baldwin et al.   NEURON

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington’s disease

(2021) Abdellatif Benraiss et al.   Cell Reports

Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing

(2021) Ekin Su Akdemir et al.   JOURNAL OF NEUROSCIENCE

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain

(2020) Brittney Lozzi et al.   Frontiers in Neuroscience

Molecular mechanisms of K + clearance and extracellular space shrinkage—Glia cells as the stars

(2020) Nanna MacAulay   GLIA

Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

(2020) Sripriya Ravindra Kumar et al.   NATURE METHODS

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

(2020) Omer Ali Bayraktar et al.   NATURE NEUROSCIENCE

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities

(2020) Anna Yu-Szu Huang et al.   NEURON

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

(2020) Hyeseung Lee et al.   NEURON

Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable

(2020) Xinzhu Yu et al.   NEURON

Systemic AAV vectors for widespread and targeted gene delivery in rodents

(2019) Rosemary C. Challis et al.   Nature Protocols

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

(2019) Jun Nagai et al.   CELL

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST

(2019) Kaoru Seiriki et al.   Nature Protocols

Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia

(2019) Bin Zhou et al.   PLOS BIOLOGY

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

(2019) Leanne M Holt et al.   eLife

Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets

(2019) Anna C. Belkina et al.   Nature Communications

An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales

(2018) J. Christopher Octeau et al.   NEURON

Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers

(2018) Darin Lanjakornsiripan et al.   Nature Communications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes

(2018) Kevin W. Kelley et al.   NATURE NEUROSCIENCE

Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors

(2018) Elena Blanco-Suarez et al.   NEURON

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior

(2018) Sukhee Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glia as architects of central nervous system formation and function

(2018) Nicola J. Allen et al.   SCIENCE

Molecular and Functional Properties of Regional Astrocytes in the Adult Brain

(2017) Lydie Morel et al.   JOURNAL OF NEUROSCIENCE

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions

(2017) Wei Sun et al.   JOURNAL OF NEUROSCIENCE

Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

(2017) Jeff A. Stogsdill et al.   NATURE

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

(2017) Kaoru Seiriki et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Detecting Activated Cell Populations Using Single-Cell RNA-Seq

(2017) Ye Emily Wu et al.   NEURON

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

(2016) R. Jiang et al.   JOURNAL OF NEUROSCIENCE

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

(2014) Anna V. Molofsky et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

(2014) Ulrike Pannasch et al.   NATURE NEUROSCIENCE

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

(2013) Eiji Shigetomi et al.   JOURNAL OF GENERAL PHYSIOLOGY

The NIH BRAIN Initiative

(2013) T. R. Insel et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Local generation of glia is a major astrocyte source in postnatal cortex

(2012) Woo-Ping Ge et al.   NATURE

Phenopedia and Genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations

(2009) W. Yu et al.   BIOINFORMATICS

GenBank

(2009) Dennis A. Benson et al.   NUCLEIC ACIDS RESEARCH

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON