Review
Biochemistry & Molecular Biology
Daniela Rossi, Enrico Pierantozzi, David Osamwonuyi Amadsun, Sara Buonocore, Egidio Maria Rubino, Vincenzo Sorrentino
Summary: The sarcoplasmic reticulum of skeletal muscle cells is an organized structure that regulates Ca2+ homeostasis and interacts with other components of muscle fibers. This review focuses on the structure and function of the two domains of the sarcoplasmic reticulum involved in excitation-contraction coupling and Ca2+ uptake mechanisms.
Review
Endocrinology & Metabolism
Hugues Dardente, Valerie Simonneaux
Summary: This article summarizes our current understanding of the neuroendocrine system that regulates the synchronization of breeding activity with photoperiod and environmental conditions. Melatonin, pars tuberalis, tanycytes, and thyroid hormones are among the key players involved in this process. Two distinct populations of hypothalamic neurons, kisspeptin and RFamide-related peptide-3, are positioned to relay the seasonal signals to gonadotropin-releasing hormone neurons.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Feng Yue, Changyou Song, Di Huang, Naagarajan Narayanan, Jiamin Qiu, Zhihao Jia, Zhengrong Yuan, Stephanie N. Oprescu, Bruno T. Roseguini, Meng Deng, Shihuan Kuang
Summary: Knockout of the PTEN gene specifically in skeletal muscle can alleviate myofiber degeneration, improve muscle function, reduce inflammation and fibrosis, and enhance the integrity of muscle basement membrane in a DMD animal model.
Article
Biochemistry & Molecular Biology
Zhicheng Zhou, Deyong Jia, Ohjoon Kwon, Shan Li, Huiyun Sun, Martine P. Roudier, Daniel W. W. Lin, Lawrence True, Colm Morrissey, Chad J. Creighton, John K. K. Lee, Li Xin
Summary: The complement system, through the membrane attack complex (MAC), plays a critical role in the innate immune response. Complement component 7 (C7) is important for MAC assembly and its expression level affects cytolytic activity. Our research demonstrates that C7 is specifically expressed by stromal cells in the prostate and its levels are inversely correlated with clinical outcomes in prostate cancer. Androgen signaling positively regulates C7 expression and replenishing C7 suppresses tumor growth, suggesting that enhancing complement activity could be a potential therapeutic approach.
Article
Genetics & Heredity
Miriam Zacchia, Giovanna Capolongo, Francesca Del Vecchio Blanco, Floriana Secondulfo, Neha Gupta, Giancarlo Blasio, Rosa Maria Pollastro, Angela Cervesato, Giulio Piluso, Giuseppe Gigliotti, Annalaura Torella, Vincenzo Nigro, Alessandra F. F. Perna, Giovambattista Capasso, Francesco Trepiccione
Summary: In this study, NGS analysis was used to analyze the genetic causes of inherited kidney disorders in 176 individuals. Unexpected genetic results were found in 5 individuals, with 3 of them having mutations in collagen type IV genes. This study highlights the crucial role of NGS in diagnosing inherited renal disorders and demonstrates the phenotypic variability in patients with mutations in collagen type IV genes.
Article
Engineering, Biomedical
Eric Parigoris, Soojung Lee, David Mertz, Madeleine Turner, Amy Y. Liu, Jason Sentosa, Sabra Djomehri, Hao Chen Chang, Kathryn Luker, Gary Luker, Celina G. Kleer, Shuichi Takayama
Summary: This study describes mammary organoids with a basal-in phenotype, achieved through specific material considerations and co-culture of cells, showing self-organization of cancer and epithelial cells inside the organoid. It was found that invasion of tumor cells is more prominent in organoids with less developed basement membranes compared to those with more defined ones.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Isabel Martinez-Pena y Valenzuela, Po-Ju Chen, Joseph Barden, Olivia Kosloski, Mohammed Akaaboune
Summary: Alpha-syntrophin and alpha-dystrobrevin are important components of the dystrophin-glycoprotein complex and play crucial roles in the maturation and maintenance of the neuromuscular junction. The study found that the synaptic phenotype is more severely impaired in double knockout mice compared to single mutant mice, and the overexpression of alpha-syn-GFP or alpha-dbn can partially restore the abnormal synaptic phenotype.
HUMAN MOLECULAR GENETICS
(2022)
Review
Cell Biology
Michael Lewis, Travis H. Stracker
Summary: The differentiation program of multiciliated cells is initiated by GEMC1 and MCIDAS, which activate key transcription factors to control the generation of multiple motile cilia. To support this, massive centriole amplification is required, along with the generation of unique deuterosomes and extensive remodeling of the cytoskeleton.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Omar Rossi, Francesco Citiulo, Francesca Mancini
Summary: Outer membrane vesicles (OMV) are naturally released exosomes that have been proposed as powerful vaccine platforms since the '80s. Concerns about potential systemic reactogenicity in humans due to pathogen-associated molecular patterns (PAMPs) have led to the development of assays to predict the risk of reactogenicity. Recent advances in chemical and genetic approaches have allowed for efficient modulation of the balance between reactogenicity and immunogenicity for the use of OMV in humans.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biology
Daarshini Ganapathy, Yasmeen Siddiqui, Khairulmazmi Ahmad, Fariz Adzmi, Kong Lih Ling
Summary: Oil palm is a key cash crop in the tropics, but Basal Stem Rot (BSR) disease caused by Ganoderma spp poses a serious threat. The pathogen infection disrupts water and nutrient uptake in the plant, leading to plant death. Research suggests that naturally occurring phenolic compounds may serve as a green control measure to suppress the pathogen.
Review
Cell Biology
Klaus Ebnet, Volker Gerke
Summary: Membrane polarity, regulated by polarized membrane trafficking and the presence of intramembrane diffusion barriers, is crucial for the development of multicellular tissues. Rho and Rab family small GTPases play important roles in cell-cell junction formation and polarized membrane traffic.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Chemical
Xiaobin Tang, Jinlong Wang, Hongjia Zhang, Miao Yu, Yuanqing Guo, Guibai Li, Heng Liang
Summary: The innovative gravity-driven membrane (GDM) process effectively removes iron and manganese contamination from surface water, with the potential to significantly contribute to the treatment of iron- and manganese-containing water. The interaction between the bio-cake layer and ultrafiltration membrane plays a crucial role in flux improvement and removal efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Cell Biology
Florian Keller, Roman Bruch, Franziska Clauder, Mathias Hafner, Ruediger Rudolf
Summary: The study found that extracellular matrix components play a significant role in regulating BSP expression, suggesting mechanisms for the formation of bone-associated metastasis in breast cancer that may involve local control of BSP levels through extracellular matrix degradation and release of growth factors.
Article
Multidisciplinary Sciences
Ramachandran Samivel, Saud A. Alanazi, Ibraheem S. Almahuby, Adnan A. Khan, Omar Kirat, Essam S. Almutleb, Ali M. Masmali
Summary: This study investigated the potential role of basement membrane and hemidesmosomes damage in the elevation of pro-apoptotic proteins in the corneal epithelium of patients with keratoconus (KC). The results showed that KC corneas exhibited damage to the Bowman's layer, hemidesmosomes, and basement membrane. The expression of pro-apoptotic proteins, including Bax, phospho-p53, and cleaved caspase-3, was significantly elevated in KC corneas compared to normal corneas.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jesus Andrade-Guerrero, Erika Orta-Salazar, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, Luis Daniel Rodriguez-Hernandez, Isaac Vargas-Rodriguez, Nayeli Barron-Leon, Carlos Ledesma-Alonso, Sofia Diaz-Cintra, Luis O. Soto-Rojas
Summary: Alzheimer's disease is a common neurodegenerative disorder with distinctive histopathological features. Vascular amyloid deposits play a role in neurovascular unit dysfunction. Physical exercise has shown positive effects on cognitive function and the integrity of the NVU, providing a potential therapeutic approach for AD patients with cerebral amyloid angiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rachel E. James, James Hillis, Istvan Adorjan, Betty Gration, Mayara V. Mundim, Asif J. Iqbal, Moon-Moon Majumdar, Richard L. Yates, Maureen M. H. Richards, Gwendolyn E. Goings, Gabriele C. DeLuca, David R. Greaves, Stephen D. Miller, Francis G. Szele
Review
Neurosciences
Eun Hyuk Chang, Istvan Adorjan, Mayara V. Mundim, Bin Sun, Maria L. V. Dizon, Francis G. Szele
FRONTIERS IN NEUROSCIENCE
(2016)
Article
Peripheral Vascular Disease
Edina A. Wappler, Istvan Adorjan, Aniko Gal, Peter Galgoczy, Kinga Bindics, Zoltan Nagy
MICROVASCULAR RESEARCH
(2011)
Article
Neurosciences
Istvan Adorjan, Kinga Bindics, Peter Galgoczy, Mihaly Kalman
EXPERIMENTAL BRAIN RESEARCH
(2014)
Article
Anatomy & Morphology
Istvan Adorjan, Teadora Tyler, Aparna Bhaduri, Samuel Demharter, Cintia Klaudia Finszter, Maria Bako, Oliver Marcell Sebok, Tomasz J. Nowakowski, Konstantin Khodosevich, Kjeld Mollgard, Arnold R. Kriegstein, Lei Shi, Anna Hoerder-Suabedissen, Olaf Ansorge, Zoltan Molnar
JOURNAL OF ANATOMY
(2019)
Article
Neurosciences
Osama Al-Dalahmah, Luana Campos Soares, James Nicholson, Swip Draijer, Mayara Mundim, Victor M. Lu, Bin Sun, Teadora Tyler, Istvan Adorjan, Eric O'Neill, Francis G. Szele
Article
Neurosciences
Osama Al-Dalahmah, Alexander A. Sosunov, A. Shaik, Kenneth Ofori, Yang Liu, Jean Paul Vonsattel, Istvan Adorjan, Vilas Menon, James E. Goldman
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
David A. Menassa, Tim A. O. Muntslag, Maria Martin-Estebane, Liam Barry-Carroll, Mark A. Chapman, Istvan Adorjan, Teadora Tyler, Bethany Turnbull, Matthew J. J. Rose-Zerilli, James A. R. Nicoll, Zeljka Krsnik, Ivica Kostovic, Diego Gomez-Nicola
Summary: This study provides a detailed insight into the spatiotemporal dynamics of microglia across the human lifespan and serves as a foundation for elucidating how microglia contribute to shaping neurodevelopment in humans.
DEVELOPMENTAL CELL
(2022)
Article
Multidisciplinary Sciences
Mykhailo Y. Batiuk, Teadora Tyler, Katarina Dragicevic, Shenglin Mei, Rasmus Rydbirk, Viktor Petukhov, Ruslan Deviatiiarov, Dora Sedmak, Erzsebet Frank, Virginia Feher, Nikola Habek, Qiwen Hu, Anna Igolkina, Lilla Roszik, Ulrich Pfisterer, Diego Garcia-Gonzalez, Zdravko Petanjek, Istvan Adorjan, Peter V. Kharchenko, Konstantin Khodosevich
Summary: Schizophrenia is a widespread and complex mental disorder characterized by a reduction in abundance of GABAergic neurons and an increase in principal neurons, especially in the upper cortical layers. Many neuronal subtypes show extensive transcriptomic changes, particularly in upper-layer GABAergic neurons. Transcription factor network analysis reveals the developmental origin of these transcriptomic changes.
Article
Anatomy & Morphology
Istvan Adorjan, Bin Sun, Virginia Feher, Teadora Tyler, Daniel Veres, Steven A. Chance, Francis G. Szele
FRONTIERS IN NEUROANATOMY
(2020)
Article
Cell Biology
M. Kalman, J. Mahalek, A. Adorjan, I. Adorjan, K. Pocsai, Z. Bagyura, S. Sadeghian
HISTOLOGY AND HISTOPATHOLOGY
(2011)
Article
Anatomy & Morphology
O Goren, I Adorján, M Kálmán
ANATOMY AND EMBRYOLOGY
(2006)