Outer membrane vesicles: moving within the intricate labyrinth of assays that can predict risks of reactogenicity in humans

Success of 4CMenB in preventing meningococcal disease: evidence from real-world experience

(2020) Catherine Isitt et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Adverse events following immunisation with four-component meningococcal serogroup B vaccine (4CMenB): interaction with co-administration of routine infant vaccines and risk of recurrence in European randomised controlled trials

(2019) Joseline Guetsop Zafack et al.   BMJ Open

Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230

(2019) Puthupparampil V. Scaria et al.   npj Vaccines

Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component

(2019) Dylan Sheerin et al.   Scientific Reports

Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination

(2018) R H M Raeven et al.   Mucosal Immunology

Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies

(2018) Taylor C. Stevenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of Vibrio cholerae outer membrane vesicles secreted at various environmental conditions

(2018) Rezaei Adriani et al.   VACCINE

Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella

(2018) Francesca Micoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meningococcal B vaccine (4CMenB): the journey from research to real world experience

(2018) Rino Rappuoli et al.   Expert Review of Vaccines

Development and validation of a monocyte activation test for the control/safety testing of an OMV-based meningococcal B vaccine

(2018) Caroline Vipond et al.   VACCINE

Evaluation of the monocyte activation test for the safety testing of meningococcal B vaccine Bexsero: A collaborative study

(2018) Lucy Studholme et al.   VACCINE

Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection

(2017) Hannah C. Watkins et al.   MOLECULAR THERAPY

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database

(2017) Thomas M. Monticello et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of O-antigen delivered by Generalized Modules for Membrane Antigens (GMMA) vaccine candidates against nontyphoidal Salmonella

(2017) G. De Benedetto et al.   VACCINE

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

(2017) Christina W. Obiero et al.   Frontiers in Immunology

Safety Profile and Immunologic Responses of a Novel Vaccine Against Shigella sonnei Administered Intramuscularly, Intradermally and Intranasally: Results From Two Parallel Randomized Phase 1 Clinical Studies in Healthy Adult Volunteers in Europe

(2017) Odile Launay et al.   EBioMedicine

Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles

(2017) Alberto Grandi et al.   Frontiers in Oncology

Development of a high-throughput method to evaluate serum bactericidal activity using bacterial ATP measurement as survival readout

(2017) Francesca Necchi et al.   PLoS One

Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis

(2016) Omar Rossi et al.   Clinical and Vaccine Immunology

Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT)

(2016) Cristiane Caldeira da Silva et al.   TOXICOLOGY IN VITRO

Polymorphic Regulation of Outer Membrane Lipid A Composition

(2016) Russell E. Bishop   mBio

Limitations of the rabbit pyrogen test for assessing meningococcal OMV based vaccines

(2016) Caroline Vipond   ALTEX-Alternatives to Animal Experimentation

A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity

(2016) David J. Dowling et al.   Frontiers in Immunology

Outer membrane vesicles as platform vaccine technology

(2015) Leo van der Pol et al.   Biotechnology Journal

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

(2015) Afshin Zariri et al.   Expert Review of Vaccines

An Impaired Inflammatory Cytokine Response to Gram-Negative LPS in Human Neonates is Associated with the Defective TLR-Mediated Signaling Pathway

(2015) Yi Ping Li et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial

(2015) L. Marsay et al.   JOURNAL OF INFECTION

Outer membrane vesicles as platform vaccine technology

(2015) Leo van der Pol et al.   Biotechnology Journal

A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles

(2015) Deborah R. Leitner et al.   Frontiers in Microbiology

Production of a Shigella sonnei Vaccine Based on Generalized Modules for Membrane Antigens (GMMA), 1790GAHB

(2015) Christiane Gerke et al.   PLoS One

An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity

(2015) Gunnstein Norheim et al.   PLoS One

Modulation of Endotoxicity ofShigellaGeneralized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications

(2014) Omar Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on Generalized Modules for Membrane Antigens (GMMA)

(2014) Oliver Koeberling et al.   VACCINE

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

(2014) Nina Hasiwa   ALTEX-Alternatives to Animal Experimentation

A phase II randomized controlled trial of a multicomponent meningococcal serogroup B vaccine, 4CMenB, in infants (II)

(2014) Susanna Esposito et al.   Human Vaccines & Immunotherapeutics

A phase 2 randomized controlled trial of a multicomponent meningococcal serogroup B vaccine (I)

(2014) Roman Prymula et al.   Human Vaccines & Immunotherapeutics

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

Lipopolysaccharide Modifications of a Cholera Vaccine Candidate Based on Outer Membrane Vesicles Reduce Endotoxicity and Reveal the Major Protective Antigen

(2013) Deborah R. Leitner et al.   INFECTION AND IMMUNITY

Site-specific acylation changes in the lipid A of Escherichia coli lpxL mutants grown at high temperatures

(2013) Birgit Schilling et al.   Innate Immunity

Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials

(2013) Timo Vesikari et al.   LANCET

Improved Production Process for Native Outer Membrane Vesicle Vaccine against Neisseria meningitidis

(2013) Bas van de Waterbeemd et al.   PLoS One

Modulating the innate immune response by combinatorial engineering of endotoxin

(2013) Brittany D. Needham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology

(2013) Ranjeet Singh Mahla   Frontiers in Immunology

Vaccine Adjuvants: Mode of Action

(2013) Ennio De Gregorio et al.   Frontiers in Immunology

Structural Modifications of Bacterial Lipopolysaccharide that Facilitate Gram-Negative Bacteria Evasion of Host Innate Immunity

(2013) Motohiro Matsuura   Frontiers in Immunology

TLR4 polymorphisms and disease susceptibility

(2012) Mamoona Noreen et al.   INFLAMMATION RESEARCH

Nonclinical vaccine safety evaluation: advantages of continuous temperature monitoring using abdominally implanted data loggers

(2012) Patricia Kaaijk et al.   JOURNAL OF APPLIED TOXICOLOGY

High Yield Production Process for Shigella Outer Membrane Particles

(2012) Francesco Berlanda Scorza et al.   PLoS One

Preclinical safety and immunogenicity evaluation of a nonavalent PorA native outer membrane vesicle vaccine against serogroup B meningococcal disease

(2012) Patricia Kaaijk et al.   VACCINE

Adjuvant properties of meningococcal outer membrane vesicles and the use of adjuvants inNeisseria meningitidisprotein vaccines

(2011) Holly Sanders et al.   Expert Review of Vaccines

NOD-Like Receptor Activation by Outer Membrane Vesicles fromVibrio choleraeNon-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

(2011) H. Bielig et al.   INFECTION AND IMMUNITY

Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate

(2011) Cristian J.A. Asensio et al.   VACCINE

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression

(2011) P.B. Keiser et al.   VACCINE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process

(2010) Bas van de Waterbeemd et al.   VACCINE

A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA

(2010) Paul B. Keiser et al.   VACCINE

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

Evaluation of a Whole-Blood Cytokine Release Assay for Use in Measuring Endotoxin Activity of Group B Neisseria meningitidis Vaccines Made from Lipid A Acylation Mutants

(2009) M. B. Stoddard et al.   Clinical and Vaccine Immunology

Phase I Safety and Immunogenicity Study of a Candidate Meningococcal Disease Vaccine Based on Neisseria lactamica Outer Membrane Vesicles

(2009) A. R. Gorringe et al.   Clinical and Vaccine Immunology

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Meningococcal Outer Membrane Vesicle Vaccines Derived from Mutant Strains Engineered To Express Factor H Binding Proteins from Antigenic Variant Groups 1 and 2

(2008) O. Koeberling et al.   Clinical and Vaccine Immunology

Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis

(2008) L. Steeghs et al.   INFECTION AND IMMUNITY

Discovery of new biosynthetic pathways: the lipid A story

(2008) Christian R. H. Raetz et al.   JOURNAL OF LIPID RESEARCH

Safety evaluation to support first-in-man investigations II: Toxicology studies

(2008) Paul Baldrick   REGULATORY TOXICOLOGY AND PHARMACOLOGY