Article
Biochemistry & Molecular Biology
Ranjithkumar Rajendran, Vinothkumar Rajendran, Mario Giraldo-Velasquez, Fevronia-Foivi Megalofonou, Fynn Gurski, Christine Stadelmann, Srikanth Karnati, Martin Berghoff
Summary: MS is a chronic inflammatory and degenerative disease of the central nervous system commonly affecting the cerebellum. FGFs and FGFRs are involved in demyelinating pathologies such as MS. Recent research shows that cell-specific deletion of FGFR1 has anti-inflammatory and neuroprotective effects in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Payam Bayat, Maral Farshchi, Mozhdeh Yousefian, Mahmoud Mahmoudi, Rezvan Yazdian-Robati
Summary: Research indicates that flavonoids can effectively alleviate the severity of multiple sclerosis and experimental autoimmune encephalomyelitis, showing potential therapeutic effects and paving the way for improving MS therapeutic strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Elif Nur Yilmaz, Stefanie Albrecht, Katharina Groll, Christian Thomas, Lutz Wallhorn, Martin Herold, Stephanie Hucke, Luisa Klotz, Tanja Kuhlmann
Summary: Multiple sclerosis (MS) is a focal inflammatory and demyelinating disease characterized by the infiltration of macrophages/microglia, T and B cells. Remyelination (RM) is an endogenous repair process that often fails in MS patients. In this study, the combination of cuprizone feeding and MOG immunization targeted T cells to the corpus callosum and increased axonal injury, but did not alter the course of RM. Our results suggest that the inflammatory environment affects axons and oligodendrocytes differently, and oligodendroglial lineage cells may be less susceptible to T cell mediated injury.
Review
Neurosciences
Kelley C. C. Atkinson, Marvellous Osunde, Seema K. K. Tiwari-Woodruff
Summary: Multiple sclerosis (MS) is a degenerative disorder of the central nervous system (CNS) with mitochondrial energy production failure. Mitochondrial morphology changes and impaired transport contribute to neurodegeneration and disability in MS. Current methodologies for studying mitochondria in MS only provide a partial understanding, and cell-specific studies in animal models are needed for a comprehensive understanding.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Marjan Gharagozloo, Matthew D. Smith, Elias S. Sotirchos, Jing Jin, Keya Meyers, Michelle Taylor, Thomas Garton, Riley Bannon, Hannah-Noelle Lord, Ted M. Dawson, Valina L. Dawson, Seulki Lee, Peter A. Calabresi
Summary: GLP-1R agonist NLY01 shows therapeutic potential in EAE mouse model by delaying disease onset, reducing severity, inhibiting immune cell activation, decreasing cell trafficking to CNS, and suppressing chemokine production associated with leukocyte recruitment to inflammation sites. Additionally, NLY01 may block the expression of genes associated with neurotoxic astrocytes, preventing RGC loss in the progressive stage of EAE and decreasing clinical score in a model of relapsing-remitting EAE.
Article
Biochemistry & Molecular Biology
Laura Moles, Ander Egimendia, Inaki Osorio-Querejeta, Leire Iparraguirre, Ainhoa Alberro, Jose Suarez, Lucia Sepulveda, Tamara Castillo-Trivino, Maider Munoz-Culla, Pedro Ramos-Cabrer, David Otaegui
Summary: This study characterized microbial changes in murine demyelinating models and found correlations with disease progression, resembling characteristics of dysbiosis in multiple sclerosis (MS) patients. The findings provide insights into the interplay between microbiota and demyelination processes, highlighting the potential for modulating microbiota as a therapeutic strategy for MS.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff
Summary: During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. This study found that the insoluble protein TMEM106B, normally lysosome-associated, is insoluble in MS plaques relative to normal-appearing white matter from individuals with Alzheimer's disease and non-neurologic controls. Hypomorphic mice with a reduction in TMEM106B have increased axonal damage and lipid droplet accumulation in the spinal cord following experimental autoimmune encephalomyelitis.
Article
Neurosciences
Maxime Donadieu, Hannah Kelly, Diego Szczupak, Jing-Ping Lin, Yeajin Song, Cecil C. C. Yen, Frank Q. Ye, Hadar Kolb, Joseph R. Guy, Erin S. Beck, Steven Jacobson, Afonso C. Silva, Pascal Sati, Daniel S. Reich
Summary: This study characterized cortical lesions in marmosets with EAE using ultrahigh-field MRI and histological analysis, finding that 65% of cortical lesions could be captured with in vivo imaging, and confirming extensive demyelination in the cortical areas of the marmoset brain.
Article
Immunology
Klara Ruppova, Jong-Hyung Lim, Georgia Fodelianaki, Avery August, Ales Neuwirth
Summary: This study found enhanced abundance of eosinophils in the inflamed spinal cord during EAE progression, but these cells were not essential for the development of EAE.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Lacey B. Sell, Christina C. Ramelow, Hannah M. Kohl, Kristina Hoffman, Jasleen K. Bains, William J. Doyle, Kevin D. Strawn, Theresa Hevrin, Trevor O. Kirby, K. Michael Gibson, Jean-Baptiste Roullet, Javier Ochoa-Reparaz
Summary: Farnesol treatment delays disease onset and reduces severity in EAE, potentially through modulation of gut microbiota composition.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li
Summary: Baicalein (BAI), a natural flavonoid, has been found to alleviate clinical symptoms, demyelination, and inflammatory response in EAE mice. It inhibits M1 microglia/macrophage activation, decreases the expression of proinflammatory cytokines, and targets STAT1 to inhibit polarization. These findings suggest the potential use of BAI in the treatment of MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna S. Thomann, Courtney A. McQuade, Katarina Pinjusic, Anna Kolz, Rosa Schmitz, Daisuke Kitamura, Hartmut Wekerle, Anneli Peters Ab
Summary: In multiple sclerosis, pathogenic T cell responses play a major role in autoimmune inflammation, but B cells may also contribute to the pathogenesis through antigen presentation and the production of proinflammatory cytokines. This study developed a new model to study the roles of pathogenic B cells in the development of multiple sclerosis, providing insights into the disease's pathogenic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Xiaoyu Ma, Zhuoxin Guo, Zhenchao Huang, Dayang Hui, Yuxin Liu, Yuxuan Jiang, Zhengqi Lu, Wei Qiu, Tingting Lu, Feng Qin
Summary: This study aimed to determine the specific magnetic resonance imaging (MRI) features of central nervous system (CNS) B-cell lymphoma and found that cohesive enhancement with satellite enhancing foci surrounded by prominent non-enhancing areas of edema is the major contrast-enhancing pattern in lymphoma patients. These imaging features can help differentiate CNS B-cell lymphoma from demyelinating diseases.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Abhishek Shastri, Ahmad Al Aiyan, Uday Kishore, Maria Elena Farrugia
Summary: Dysfunction of the immune system can lead to peripheral nervous system damage. The immune mechanisms involve inflammation and proliferation of Schwann cells and result in demyelination and axonal degeneration. Animal models have contributed to understanding the pathophysiology of inflammatory polyradiculoneuropathies. Detection of specific antibodies aids in diagnosis. Paraneoplastic neuropathies are immune-mediated reactions to tumor cells. This review discusses the immunological and pathophysiological mechanisms, as well as the electrophysiological characteristics, laboratory features, and treatment options of dysimmune neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Seyedmousa Motavallihaghi, Mojgan Ghaemipanaeian, Sara Soleimani Asl, Faeze Foroughi-Parvar, Amir Hossein Maghsood
Summary: This study aimed to investigate the effect of Toxoplasma gondii infection on a multiple sclerosis (MS) mouse model. The results showed that chronic toxoplasmosis could inhibit the development of MS, reduce clinical symptoms, and decrease the levels of inflammatory cells and cytokines. These findings suggest that chronic toxoplasmosis may have therapeutic potential for MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Douglas L. Feinstein, Robert P. Skoff
JOURNAL OF NEUROINFLAMMATION
(2016)
Article
Neurosciences
Jeremy J. Laukka, John Kamholz, Denise Bessert, Robert P. Skoff
NEUROSCIENCE LETTERS
(2016)
Article
Neurosciences
Mallika Somayajulu, Denise A. Bessert, Maik Huttemann, Jasloveleen Sohi, John Kamholz, Robert P. Skoff
NEUROSCIENCE LETTERS
(2018)
Article
Pathology
Ajaib S. Paintlia, Manjeet K. Paintlia, Bruce W. Hollis, Avtar K. Singh, Inderjit Singh
AMERICAN JOURNAL OF PATHOLOGY
(2012)
Article
Neurosciences
Carrie L. Tatar, Sunita Appikatla, Denise A. Bessert, Ajaib S. Paintlia, Inderjit Singh, Robert P. Skoff
Article
Neurosciences
Sylvia Fitting, Bogna M. Ignatowska-Jankowska, Cecilia Bull, Robert P. Skoff, Aron H. Lichtman, Laura E. Wise, Michael A. Fox, Jianmin Su, Alexandre E. Medina, Thomas E. Krahe, Pamela E. Knapp, William Guido, Kurt F. Hauser
BIOLOGICAL PSYCHIATRY
(2013)
Article
Neurosciences
Ajaib S. Paintlia, Manjeet K. Paintlia, Avtar K. Singh, John K. Orak, Inderjit Singh
Review
Neurosciences
Carrie Tatar, Denise Bessert, Harley Tse, Robert P. Skoff
Article
Neurosciences
Sunita Appikatla, Denise Bessert, Icksoo Lee, Maik Huettemann, Chadwick Mullins, Mallika Somayajulu-Nitu, Fayi Yao, Robert P. Skoff
Article
Biochemistry & Molecular Biology
Manjeet K. Paintlia, Ajaib S. Paintlia, Avtar K. Singh, Inderjit Singh
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Immunology
Jinzhu Li, Xiaoqing Zhao, Robert Skoff, Michael K. Shaw, Harley Y. Tse
JOURNAL OF NEUROIMMUNOLOGY
(2011)
Article
Neurosciences
Kristi Clark, Lauren Sakowski, Karen Sperle, Linda Banser, Carlisle P. Landel, Denise A. Bessert, Robert P. Skoff, Grace M. Hobson
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Muthulekha Swamydas, Denise Bessert, Robert Skoff
JOURNAL OF NEUROSCIENCE RESEARCH
(2009)