Review
Oncology
Yuriko Saiki, Can Jiang, Masaki Ohmuraya, Toru Furukawa
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and a major cause of cancer-related deaths worldwide. Recent multi-gene analysis methods have provided valuable insight into the molecular characteristics of pancreatic tumors, with different types of pancreatic cancer and precursor lesions showing specific molecular alterations. Genetically engineered mouse models (GEMMs) driven by oncogenic Kras have proven to be useful in understanding the roles of altered genes and recapitulating key features of human PDAC.
Article
Oncology
Xiufang Wu, Fei Qin, Qiangze Zhang, Jianling Qiao, Yulian Qi, Bing Liu
Summary: This study investigated the effectiveness of different treatments in advanced HPB cancer patients. The results showed that immunotherapy reduced opioid consumption and improved pain management compared to other treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Medicinal
Jul Dardare, Andrea Witz, Jean-Louis Merlin, Agathe Bochnakian, Paul Toussaint, Pauline Gilson, Alexandre Harle
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late-stage diagnosis. EMT plays a significant role in PDAC, not only related to cancer progression and metastasis, but also potentially becoming a new therapeutic target.
Review
Oncology
C. Roecken
Summary: This review summarizes the advancements in tissue-based diagnostic biomarkers for gastric cancer, including different types of gastric cancer and their associated molecular changes. The importance of adequate tissue sampling and the risk of sampling error in gastric cancer biomarker research are also highlighted.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Neus Martinez-Bosch, Helena Cristobal, Mar Iglesias, Meritxell Gironella, Luis Barranco, Laura Visa, Domenico Calafato, Silvia Jimenez-Parrado, Julie Earl, Alfredo Carrato, Noemi Manero-Ruperez, Mireia Moreno, Albert Morales, Carmen Guerra, Pilar Navarro, Pablo Garcia de Frutos
Summary: This study explores the use of sAXL as a biomarker for pancreatic ductal adenocarcinoma (PDAC). The research shows that AXL is increased in PDAC tissues and plasma sAXL concentrations are elevated in PDAC patients. Higher levels of AXL are associated with lower overall survival. sAXL performs better than CA19-9 in discriminating between PDAC and chronic pancreatitis (CP). The combination of sAXL and CA19-9 improves the diagnostic value.
Review
Oncology
Donghan Xu, Yehao Luo, Peng Wang, Jiaxin Li, Linrui Ma, Jie Huang, Hao Zhang, Xiaoman Yang, Liqi Li, Yuhong Zheng, Gang Fang, Peiyu Yan
Summary: The incidence of gastric cancer is increasing and current treatment options are not satisfactory due to most cases being diagnosed at an advanced stage. Anti-angiogenesis targeted therapies have shown potential for gastric cancer treatment. In this review, the efficacy and safety of various targeted drugs were evaluated, and response biomarkers were identified. The challenges and available solutions for anti-angiogenesis therapy in gastric cancer were also discussed. This review provides valuable references for future clinical research in this field.
FRONTIERS IN ONCOLOGY
(2023)
Review
Neurosciences
Bo Ni, Yiqing Yin, Zekun Li, Junjin Wang, Xiuchao Wang, Kaiyuan Wang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with late diagnosis and therapy resistance. The peripheral nerve has been found to play an important role in tumor growth and immune escape in the tumor microenvironment. Understanding the crosstalk between the neuronal system and PDAC may provide new insights into tumor progression and potential therapeutic targets.
NEUROSCIENCE BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Anna C. Lilly, Igor Astsaturov, Erica A. Golemis
Summary: Pancreatic cancer is difficult to detect and treat, resulting in poor survival outcomes. The increasing incidence of this cancer is related to aging populations, obesity, and pancreatitis. Risk factors for pancreatic cancer include signaling from fat cells, elevated levels of intrapancreatic adipocytes, inflammation from immune cells, and fibrosis caused by pancreatic obstruction and cell lysis. Further studies are needed to understand the role of adipocytes in the pre-cancerous niche and their implications in mouse models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Meilin Xue, Minmin Shi, Junjie Xie, Jun Zhang, Lingxi Jiang, Xiaxing Deng, Chenghong Peng, Baiyong Shen, Hong Xu, Hao Chen
Summary: This study identified tsRNAs as potential biomarkers for early detection of PDAC, with tsRNA-ValTAC-41 and tsRNA-MetCAT-37 showing high diagnostic accuracy and predictive performance in the serum of PDAC patients. These tsRNAs could be promising candidates for the development of highly sensitive and noninvasive biomarkers for PDAC diagnosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Genetics & Heredity
Periyasamy Murugesan, Habeebunnisa Begum, Anjana Devi Tangutur
Summary: ID proteins, a family of cell differentiation inhibitors or DNA-binding proteins, function as powerful transcription factors in various cellular processes, including inhibiting differentiation, promoting cell-cycle progression, senescence, angiogenesis, tumorigenesis, and metastasis in pancreatic cancer. Pancreatic cancer is the deadliest cancer with the lowest survival rate of 10% due to its advanced fatal stage diagnosis and therapeutic resistance. Surgery is currently the only curative option, but it is only performed in a minority of patients due to the aggressive nature of the cancer. Therefore, identifying early biomarkers and targeting the hallmarks of pancreatic cancer can improve treatment and survival. This review explores the potential roles of ID proteins in pancreatic cancer and their effects, providing new insights into tumorigenesis mechanisms.
Article
Oncology
Matteo Ponzo, Anais Debesset, Melissande Cossutta, Mounira Chalabi-Dchar, Claire Houppe, Caroline Pilon, Alba Nicolas-Boluda, Sylvain Meunier, Fabio Raineri, Allan Thiolat, Remy Nicolle, Federica Maione, Serena Brundu, Carina Florina Cojocaru, Philippe Bouvet, Corinne Bousquet, Florence Gazeau, Christophe Tournigand, Jose Courty, Enrico Giraudo, Jose L. Cohen, Ilaria Cascone
Summary: This study explores the effects of a selective inhibitor of nucleolin (NCL) on the immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), and highlights a new therapeutic strategy to restrain immunosuppressive cells, promote T-cell recruitment and activation, and re-program the tumor stroma of PDAC.
Review
Pharmacology & Pharmacy
Sareshma Sudhesh Dev, Syafiq Asnawi Zainal Abidin, Reyhaneh Farghadani, Iekhsan Othman, Rakesh Naidu
Summary: Receptor tyrosine kinases (RTKs) are crucial cell-surface proteins that regulate essential cellular processes, with alterations in them playing a key role in cancer progression. Curcumin, as an attractive anti-cancer agent, exhibits potent effects by inhibiting RTKs and downstream signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Boya Li, Yu Feng, Qiaoyun Hou, Yan Fu, Yongzhang Luo
Summary: This study found that high expression of antigen peptide transporter 1 (TAP1) is associated with MEKi resistance in pancreatic cancer. Suppression of TAP1 significantly increases sensitivity of pancreatic cancer cells to MEKi, reduces tumor growth, and attenuates inhibition of the KRAS signaling pathway. TAP1 may serve as a marker for predicting patient response to MEKi, and combining TAP1 suppression with MEKi may be a novel therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Yangchun Xie, Jiao Liu, Rui Kang, Daolin Tang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive solid malignancy with poor response to current therapies and low overall survival rate, often associated with oncogenic KRAS mutations. Autophagy plays a dual role in the regulation of PDAC initiation and progression, while mitophagy is crucial for understanding the occurrence and treatment of PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Darya Javadrashid, Amir Baghbanzadeh, Afshin Derakhshani, Patrizia Leone, Nicola Silvestris, Vito Racanelli, Antonio Giovanni Solimando, Behzad Baradaran
Summary: Genetic alterations, particularly the K-Ras mutation, play a major role in the progression of pancreatic precursor lesions into PDAC. The tumor microenvironment and immune evasion are challenges in therapeutic approaches, with targeting signaling molecules and immune checkpoint inhibition showing promising results in pancreatic cancer treatment.
Review
Pharmacology & Pharmacy
Asuncion Martinez-Anton, Delphine Gras, Arnaud Bourdin, Patrice Dubreuil, Pascal Chanez
PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Endocrinology & Metabolism
Y. Degboe, M. Eischen, P. A. Apoil, C. Mailhol, P. Dubreuil, O. Hermine, C. Paul, C. Bulai Livideanu, M. Laroche
OSTEOPOROSIS INTERNATIONAL
(2019)
Article
Allergy
Richard Lemal, Guillemette Fouquet, Louis Terriou, Melanie Vaes, Cristina Bulai Livideanu, Laurent Frenzel, Stephane Barete, Danielle Canioni, Ludovic Lhermitte, Julien Rossignol, Michel Arock, Patrice Dubreuil, Olivier Lortholary, Olivier Hermine
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2019)
Article
Hematology
Ellen Weisberg, Chengcheng Meng, Abigail E. Case, Martin Sattler, Hong L. Tiv, Prafulla C. Gokhale, Sara J. Buhrlage, Xiaoxi Liu, Jing Yang, Jinhua Wang, Nathanael Gray, Richard M. Stone, Sophia Adamia, Patrice Dubreuil, Sebastien Letard, James D. Griffin
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Clinical Neurology
Jesus S. Mora, Angela Genge, Adriano Chio, Conrado J. Estol, Delia Chaverri, Maria Hernandez, Saul Marin, Javier Mascias, Gabriel E. Rodriguez, Monica Povedano, Andres Paipa, Raul Dominguez, Josep Gamez, Maria Salvado, Christian Lunetta, Carlos Ballario, Nilo Riva, Jessica Mandrioli, Alain Moussy, Jean-Pierre Kinet, Christian Auclair, Patrice Dubreuil, Vincent Arnold, Colin D. Mansfield, Olivier Hermine
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2020)
Article
Physics, Applied
C. M. Purser, V. P. Bhallamudi, F. Guo, M. R. Page, Q. Guo, G. D. Fuchs, P. C. Hammel
APPLIED PHYSICS LETTERS
(2020)
Article
Physics, Applied
B. A. McCullian, M. Chilcote, V. P. Bhallamudi, C. M. Purser, E. Johnston-Halperin, P. C. Hammel
PHYSICAL REVIEW APPLIED
(2020)
Article
Multidisciplinary Sciences
Brendan A. McCullian, Ahmed M. Thabt, Benjamin A. Gray, Alex L. Melendez, Michael S. Wolf, Vladimir L. Safonov, Denis V. Pelekhov, Vidya P. Bhallamudi, Michael R. Page, P. Chris Hammel
NATURE COMMUNICATIONS
(2020)
Article
Physics, Applied
Guanzhong Wu, Yang Cheng, Side Guo, Fengyuan Yang, Denis V. Pelekhov, P. Chris Hammel
Summary: FMRFM is a powerful scanned probe technique that can be used to measure Gilbert damping in ferromagnetic materials; spatially resolved imaging of Gilbert damping can be achieved by measuring the LM resonance cone angle using the LM resonance peak height; this approach allows determination of damping through field-swept FMRFM at a single excitation frequency.
APPLIED PHYSICS LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Nino Guy Cassuto, David Piquemal, Florence Boitrelle, Lionel Larue, Nathalie Ledee, Ghada Hatem, Lea Ruoso, Dominique Bouret, Jean-Pierre Siffroi, Alexandre Rouen, Said Assou
Summary: This study demonstrates a strong correlation between sperm morphology and gene expression, providing a biomarker panel for sperm analysis during ART and a new tool to explore male infertility.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Guanzhong Wu, Dongying Wang, Nishchhal Verma, Rahul Rao, Yang Cheng, Side Guo, Guixin Cao, Kenji Watanabe, Takashi Taniguchi, Chun Ning Lau, Fengyuan Yang, Mohit Randeria, Marc Bockrath, P. Chris Hammel
Summary: In this study, we report the emergence of perpendicular magnetic anisotropy and enhanced Gilbert damping induced by interfacial interactions in a heterostructure made of YIG and WTe2. The ability of WTe2 to enhance PMA in FM thin film, combined with its capability to generate out-of-plane damping like spin torque, makes it desirable for magnetic memory applications.
Article
Immunology
Haifa Bichiou, Sameh Rabhi, Cherif Ben Hamda, Cyrine Bouabid, Meriam Belghith, David Piquemal, Bernadette Trentin, Imen Rabhi, Lamia Guizani-Tabbane
Summary: The interaction between macrophages and Leishmania is crucial for parasite growth and disease outcome. Macrophages employ various strategies, including oxidative burst, to combat invaders. The transcription of cytoprotective and detoxifying enzymes is regulated by the nuclear factor Nrf2 to enhance cell survival. The parasite actively represses the transcription of certain genes, leading to increased survival and multiplication, especially in specific mouse strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Physics, Applied
Inhee Lee, Chi Zhang, Simranjeet Singh, Brendan McCullian, P. Chris Hammel
Summary: This study investigates the physical origin of nonlinear damping in Pt/Py heterostructures driven by spin-orbit torque, specifically examining the mode coupling between multiple auto-oscillatory modes. The results show a transition in the nonlinear damping and power redistribution among the modes, indicating the activation of another relaxation process. Additionally, the study finds that the mode coupling occurs through a nonthermal magnon-scattering process, independent of temperature. These findings have significant implications for understanding the complex nonlinear spin dynamics in multimode spin-wave systems and controlling the interaction between nonlinear magnetic oscillators.
PHYSICAL REVIEW APPLIED
(2022)
Article
Medicine, General & Internal
Manuela Lotierzo, Romain Bruno, Amanda Finan-Marchi, Fabien Huet, Eran Kalmanovich, Glaucy Rodrigues, Anne-Marie Dupuy, Jerome Adda, David Piquemal, Sylvain Richard, Jean-Paul Cristol, Francois Roubille
Summary: This study aimed to stratify HFpEF and HFrEF patients using biochemical markers and clinical data, developing a Machine Learning strategy to distinguish the two groups based on blood signature. Results showed that combining biochemical and clinical markers can be an excellent entry to develop a computer classification tool to diagnose HFpEF.
MEDICINA-LITHUANIA
(2021)
Article
Oncology
David Piquemal, Florian Noguier, Fabien Pierrat, Roman Bruno, Jerome Cros