Letter
Immunology
Leon Caly, Ashleigh F. Porter, Joanna Chua, James P. Collet, Julian D. Druce, Michael G. Catton, Sebastian Duchene
Summary: During a mouse plague in early 2021, a farmer from New South Wales, Australia, was diagnosed with locally acquired lymphocytic choriomeningitis virus infection. Whole-genome sequencing revealed a divergent and geographically distinct strain of lymphocytic choriomeningitis virus compared to other published sequences.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mark J. G. Bakkers, Alex Moon-Walker, Rasmus Herlo, Vesna Brusic, Sarah Hulsey Stubbs, Kathryn M. Hastie, Erica Ollmann Saphire, Tomas L. Kirchhausen, Sean P. J. Whelan
Summary: LCMV is a virus that enters cells by binding to different receptors and causes severe health problems. This study found that LCMV first binds to CD164 before entering cells, providing new targets for therapeutic interventions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Daniel Grupel, Yaniv Lustig, Tal Brosh-Nissimov
Summary: Lymphocytic choriomeningitis virus (LCMV) is an often-overlooked virus that can have severe consequences. We present the first documented infection by LCMV in Israel, and the epidemiology of LCMV is evolving with the potential for a worldwide endemicity, highlighting the need for increased awareness and testing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Da Di, Qinfeng Huang, Hinh Ly, Yuying Liang
Summary: Lassa virus (LASV) can cause lethal hemorrhagic fever disease in humans, while other arenaviruses like Pichinde virus (PICV) do not. The Z protein of LASV has been shown to inhibit the innate immune receptor RIG-I, while PICV Z does not. In this study, a stable HeLa cell line was developed to express RIG-I N-terminal effector domain, and recombinant PICVs were generated to compare the effects of LASV Z and PICV Z on viral gene expression and infection. LASV Z showed stronger effects in increasing viral gene expression and infection, especially when RIG-I signaling was activated.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Thi Hong Van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron
Summary: This study identified a novel, specific but weak inhibitor of the arenavirus exonuclease using in silico screening and an enzymatic assay, which may provide a new therapeutic approach for arenavirus infections.
Article
Microbiology
Jamin Liu, Kristeene A. Knopp, Elze Rackaityte, Chung Yu Wang, Matthew T. Laurie, Sara Sunshine, Andreas S. Puschnik, Joseph L. DeRisi
Summary: This study identifies novel host factors associated with Lymphocytic choriomeningitis virus (LCMV) infection of human tissues, highlighting the importance of CD164 in viral entry and suggesting it as a potential therapeutic target for congenital infection.
Article
Immunology
Jonathan Dyal, Shiv Gandhi, Caitlin M. Cossaboom, Austin Leach, Ketan Patel, Marjorie Golden, Joseph Canterino, Marie-Louise Landry, Debi Cannon, Mary Choi, Inna Krapiunaya, John D. Klena, Trevor Shoemaker
Summary: Lymphocytic choriomeningitis virus is an underreported cause of miscarriage and neurologic disease. Surveillance remains challenging due to nonspecific symptomatology, inconsistent case reporting, and difficulties with diagnostic testing.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Weldy Bonilla, Nicole Kirchhammer, Anna-Friederike Marx, Sandra M. Kallert, Magdalena A. Krzyzaniak, Min Lu, Stephanie Darbre, Sarah Schmidt, Josipa Raguz, Ursula Berka, Ilena Vincenti, Mindaugas Pauzuolis, Romy Kerber, Sabine Hoepner, Stephan Guenther, Carsten Magnus, Doron Merkler, Klaus K. Orlinger, Alfred Zippelius, Daniel D. Pinschewer
Summary: This study engineered two distantly related arenaviruses for therapeutic cancer vaccination and demonstrated that a prime-boost regimen with these viruses induced tumor-specific CTL responses and eliminated established solid tumors in mice. The findings suggest that combining two genealogically distantly related arenaviruses allows reshuffling of immunodominance hierarchies and breaking self-directed tolerance for effective tumor control.
CELL REPORTS MEDICINE
(2021)
Article
Infectious Diseases
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J. V. M. Mbadinga, Rodrigue Bikangui, Chimene Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W. E. Ella, Lilian B. M. Koumba, Branly C. B. B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L. M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V. N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda
Summary: The study revealed a seroprevalence of 21.5% for LCMV in Gabon, with higher rates in males and adults. Local rodents, shrews, and porcupines around semi-urban areas posed an infection risk.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Jasmin Mischke, Sebastian Klein, Austin Seamann, Immo Prinz, Liisa Selin, Dario Ghersi, Markus Cornberg, Anke R. M. Kraft
Summary: Our study investigated the cross-reactive immune response in chronic viral infection, and found that cross-reactive CD8(+) T cells still exist and play a clinically relevant role in chronic infections. Furthermore, checkpoint inhibitor therapy had an impact on chronic infection but did not majorly affect heterologous immunity.
Article
Virology
Peter Pankovics, Arnold Nagy, Zoltan Nyul, Annamaria Juhasz, Karoly Takats, Akos Boros, Gabor Reuter
Summary: This retrospective study aimed to detect lymphocytic choriomeningitis virus (LCMV) RNA in cerebrospinal fluid samples from patients with unknown central nervous system infections in Hungary. Two LCMV cases were identified, belonging to different genetic lineages. This is the first publication of confirmed human LCMV infections in Hungary using molecular methods.
ARCHIVES OF VIROLOGY
(2023)
Article
Immunology
Morgan Brisse, Qinfeng Huang, Mizanur Rahman, Da Di, Yuying Liang, Hinh Ly
Summary: The study demonstrates the crucial roles of MDA5 and RIG-I in controlling Pichinde virus infection in mice. Knockout of MDA5 or both MDA5 and RIG-I results in significantly higher virus titers and lower early IFN-I expression following PICV infection, but a later and heightened adaptive immune response for clearance of the infection is observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bao-Li Zhang, Peng Yu, En-Yong Su, Chun-Yu Zhang, Shi-Yao Xie, Xue Yang, Yun-Zeng Zou, Ming Liu, Hong Jiang
Summary: Pyroptosis is a pro-inflammatory cell death mediated by GSDMD activation, and targeting GSDMD activation can reduce vascular inflammation and atherosclerotic lesion development.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Thomas Ferenc, Mateja Vujica, Anna Mrzljak, Tatjana Vilibic-Cavlek
Summary: This study summarizes the epidemiological, clinical, and diagnostic features of reported patients with congenital LCMV infection. A total of 27 studies with 86 patients were included, and the results showed that 52.73% of the patients were males. Common clinical manifestations included chorioretinitis, hydrocephalus, and psychomotor retardation or developmental delay. The diagnosis was most often confirmed serologically, and computed tomography and/or magnetic resonance imaging revealed ventriculomegaly, periventricular calcifications, and microcephaly. Mothers of congenitally infected infants were often exposed to mice during pregnancy, with flu-like symptoms occurring primarily in the first two trimesters.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Cell Biology
In-Gu Lee, Yong-Hyun Joo, Hoyeon Jeon, Raehyuk Jeong, Eui Ho Kim, Hyunwoo Chung, Seong-il Eyun, Jeongkyu Kim, Young-Jin Seo, So-Hee Hong
Summary: Gal-4 enhances the immunostimulatory activity of M2 macrophages upon viral infection, leading to the reinforced antiviral functionality of CD4(+) T cells.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Immunology
Junji Xing, Ao Zhang, Laurie J. Minze, Xian Chang Li, Zhiqiang Zhang
JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Ning Lu, Ying Li, Zhiqiang Zhang, Junji Xing, Ying Sun, Sheng Yao, Lieping Chen
NATURE COMMUNICATIONS
(2018)
Article
Immunology
Yaling Dou, Junji Xing, Gangcheng Kong, Guangchuan Wang, Xiaohua Lou, Xiang Xiao, Eric Vivier, Xian C. Li, Zhiqiang Zhang
JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ao Zhang, Junji Xing, Tianliang Xia, Hua Zhang, Mingli Fang, Shibing Li, Yong Du, Xian C. Li, Zhiqiang Zhang, Mu-Sheng Zeng
Article
Multidisciplinary Sciences
Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang
Summary: In this study, the authors highlight the role of PARP9 in detecting viral RNA and inducing the IFN pathway via the PI3K/AKT3 pathway.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Junji Xing, Xiaojing Zhou, Mingli Fang, Evan Zhang, Laurie J. Minze, Zhiqiang Zhang
Summary: The study reveals the critical role of RNA helicase DHX15 in sensing enteric RNA viruses and controlling intestinal inflammation in intestinal epithelial cells, through triggering NLRP6 inflammasome assembly and IL-18 secretion.
Editorial Material
Immunology
Rongtuan Lin, Junji Xing, Chunfu Zheng
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Evan Zhang, Mingli Fang, Colette Jones, Laurie J. Minze, Junji Xing, Zhiqiang Zhang
Summary: This review summarizes the mechanisms of enteric RNA virus-induced intestinal inflammation, including the sensing mechanisms, signaling pathways, and maintenance of intestinal homeostasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Immunology
Jerry Zhang, Junji Xing
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li
Summary: In this study, the crystal structure of TRIM56, a member of the RING E3 ligase, was solved. It was found that TRIM56 forms a tetramer consisting of two anti-parallel dimers. This tetramer structure allows for the existence of two RING domains on each side, forming an active homodimer that supports ubiquitin transfer. These findings suggest that the coiled-coil domain-mediated tetramer serves as a feasible scaffold for facilitating ubiquitin recruitment and transfer in E3 ligase activity.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li
Summary: Protein ubiquitination is crucial for controlling protein degradation and cell signaling pathways. This study elucidated the crystal structure of TRIM75, a member of the RING E3 ligase family, revealing its tetrameric structure and function.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Cell Biology
Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing, Zhiqiang Zhang
Summary: Our study shows that TRIM18 negatively regulates viral myocarditis, lung inflammation, and brain damage by downregulating innate immune activation induced by both RNA and DNA viruses. We demonstrate that TRIM18 recruits PPM1A to inactivate TBK1, which blocks the interaction between TBK1 and its upstream adaptors during viral infections. Additionally, TRIM18 stabilizes PPM1A through K63-linked ubiquitination.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Meeting Abstract
Immunology
Mingli Fang, Junji Xing, Zhiqiang Zhang
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
Junji Xing, Ao Zhang, Laurie J. Minze, Xian Chang Li, Zhiqiang Zhang
JOURNAL OF IMMUNOLOGY
(2018)
Meeting Abstract
Immunology
Yaling Dou, Junji Xing, Xianchang Li, Zhiqiang Zhang
JOURNAL OF IMMUNOLOGY
(2018)
