Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ming Ma, Guoyang Li, Minghui Qi, Wei Jiang, Rongbin Zhou
Summary: Inhaled allergens promote activation of NLRP3 inflammasome, leading to allergic asthma. The study found that NLRP3 in alveolar macrophages plays a role in promoting the development of allergic asthma through an inflammasome-dependent mechanism. Targeting the NLRP3 inflammasome with small molecules may offer new treatment options for this disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xinyue Hu, Yingchun Shen, Yilin Zhao, Ji Wang, Xin Zhang, Wei Tu, William Kaufman, Juntao Feng, Peisong Gao
Summary: The study found that cockroach allergen induces overexpression of Muc5ac in human bronchial epithelial cells and asthma mouse model. Aryl hydrocarbon receptor (AhR) and mitochondrial ROS-NLRP3 inflammasome play important roles in regulating Muc5ac expression and airway inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Annamneedi Venkata Prakash, Il-Ho Park, Jun Woo Park, Jae Pil Bae, Geum Seon Lee, Tae Jin Kang
Summary: Innate immunity is the body's first line of defense, sensing danger signals and activating inflammation against infections and cellular stress. Pattern recognition receptors (PRRs) on cell membranes detect pathogen-associated molecular patterns (PAMPs) and activate innate immunity through inflammatory cells and cytokines. Inflammasomes, protein complexes in innate immunity, remove pathogens and repair tissues. This review focuses on the role of the NLRP3 inflammasome in inflammatory diseases like asthma, atopic dermatitis, and sepsis.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yeon-Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae-Hwan Kim, Ho-Soo Lee, Young-Suk Yoo, June Heo, Jae-Ho Lee, Myung-Hee Kwon, Ho Chul Kang, Jong-Soo Lee, Hyeseong Cho
Summary: The NLRP3 inflammasome is activated through mitochondria-mediated ubiquitination by the E3 ligase MARCH5. Knockout of MARCH5 leads to an impaired secretion of IL-1β and IL-18 in myeloid cells, as well as a decreased mortality rate upon infection. MARCH5-dependent NLRP3 ubiquitination is essential for NLRP3-NEK7 complex formation and NLRP3 oligomerization.
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Article
Cell Biology
Qi Cheng, Fanghan He, Wenqi Zhao, Xianhong Xu, Yunxiao Shang, Wanjie Huang
Summary: This study explores whether respiratory syncytial virus (RSV) infection in early life can lead to excessive expression of orosomucoid 1-like protein 3 (ORMDL3) and NOD-like receptor protein 3 (NLRP3) inflammasome, and analyzes the role of histone acetylation in ORMDL3 regulation. The results suggest that overexpression of ORMDL3 is an independent risk factor for repeated wheezing caused by RSV, and RSV activates ORMDL3 expression through histone hyperacetylation, inducing NLRP3 inflammasome overexpression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Medicine, Research & Experimental
Xu Zheng, Dan Zhao, Ye Jin, Yang Liu, Da Liu
Summary: The NLRP3 inflammasome plays a crucial role in the innate immune system and is associated with the development of various gynecological diseases. Inhibitors of NLRP3 inflammasome have therapeutic potential in maintaining cellular and tissue health, but excessive use can lead to adverse effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao
Summary: USP5 acts as a key scaffold protein in recruiting the E3 ligase MARCHF7 for autophagic degradation of NLRP3 independently of its deubiquitinating enzyme activity. Knockdown of USP5 promotes inflammatory signaling release, while overexpression has inhibitory effects.
Review
Cell Biology
Zhangwang Li, Xinyue Chen, Junjie Tao, Ao Shi, Jing Zhang, Peng Yu
Summary: Exosomes play a unique and critical role as signal molecules vector in various diseases, particularly in immune progression. However, the mechanisms and clinical treatment related to exosomes and NLRP3 are still not fully understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Yaxin Wu, Xin Di, Min Zhao, Haoran Li, Li Bai, Ke Wang
Summary: Asthma and COPD are lung diseases related to abnormal immune responses, and the NLRP3 inflammasome may play a crucial role in their pathogenesis. Targeting the NLRP3 inflammasome could be a potential therapeutic approach.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Immunology
Yanbing Qiu, Yumei Huang, Meilin Chen, Yuqin Yang, Xiaoxu Li, Wenling Zhang
Summary: NLRP3 inflammasome is an intracellular polyprotein complex that is activated by perceiving different molecular patterns. Intracellular mtDNA and extracellular mtDNA have different functions in activating NLRP3 inflammasome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Wanyi Huang, Ziqi Zhang, Yueyang Qiu, Yuan Gao, Yongqiang Fan, Qiang Wang, Qing Zhou
Summary: Implant surgery triggers inflammatory reactions that impact postoperative outcomes. The inflammasome has a crucial role in inflammation, inducing pyroptosis and producing interleukin-1 beta. The activation of the inflammasome in bone healing after implant surgery needs to be studied. Research has focused on metal-induced NLRP3 inflammasome activation due to the prominence of metals as implant materials. This review consolidates knowledge on NLRP3 inflammasome structures, activation mechanisms, and metal-induced NLRP3 inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jonathan C. Kagan
Summary: Diverse inflammasome stimuli recruit NLRP3 to dysfunctional endosomes via interactions with lipids that accumulate in excess on these organelles. Excess lipid detection may be a common principle that explains NLRP3 function in health and disease.
Review
Immunology
Han Cheng, Lingling Chen, Minchun Huang, Jin Hou, Zhifeng Chen, Xiaojun Yang
Summary: NLRP3 inflammasome plays a key role in radiation-induced tissue injury, but its potential value is not adequately recognized. Early intervention/prevention strategies targeting NLRP3 inflammasome may help resolve clinical problems caused by radiation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang
Summary: In this study, the authors highlight the role of PARP9 in detecting viral RNA and inducing the IFN pathway via the PI3K/AKT3 pathway.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Immunology
Rongtuan Lin, Junji Xing, Chunfu Zheng
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Nannan Zhu, Qian Wang, Zhidong Wu, Yan Wang, Mu-Sheng Zeng, Yan Yuan
Summary: Epstein-Barr virus (EBV) is associated with various malignant diseases, including nasopharyngeal carcinoma (NPC). The virus-encoded oncoprotein LMP1 promotes the development of cancer stem cells (CSCs) in NPC by activating the PI3K/mTOR/Akt signaling pathway. Different mTOR pathways, mTORC1 and mTORC2, contribute to the acquisition of distinct CSC characteristics and cooperate to regulate NPC metastasis.
JOURNAL OF VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Evan Zhang, Mingli Fang, Colette Jones, Laurie J. Minze, Junji Xing, Zhiqiang Zhang
Summary: This review summarizes the mechanisms of enteric RNA virus-induced intestinal inflammation, including the sensing mechanisms, signaling pathways, and maintenance of intestinal homeostasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Yong Du, Marie Dominique Ah Kioon, Paoline Laurent, Vidyanath Chaudhary, Michael Pierides, Chao Yang, David Oliver, Lionel B. Ivashkiv, Franck J. Barrat
Summary: The authors describe a noncanonical role for multiple chemokines to serve as nucleic acid delivery vectors to modulate TLR signaling, with implications for the chronic presence of IFN-I in autoimmune diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Virology
Cong Sun, Run-Yu Yuan, Chu Xie, Jiu-Feng Sun, Xin-Yan Fang, Yi-Sha Hu, Xiao-Hui Yu, Zheng Liu, Mu-Sheng Zeng, Yin-Feng Kang
Summary: The S1-conjugated nanoparticle vaccine designed in this study has the potential to generate potent and cross-reactive immunity against various SARS-CoV-2 variants, as well as other pathogenic betacoronaviruses.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Chao Yang, Mahesh Bachu, Yong Du, Caroline Brauner, Ruoxi Yuan, Marie Dominique Ah Kioon, Giancarlo Chesi, Franck J. Barrat, Lionel B. Ivashkiv
Summary: Chemokine CXCL4 synergizes with TLR8 to activate TBK1 and IKK epsilon, inducing epigenetic remodeling of inflammatory genes and enhancing inflammatory responses in human monocytes.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Ling Zhong, Claude Krummenacher, Wanlin Zhang, Junping Hong, Qisheng Feng, Yixin Chen, Qinjian Zhao, Mu-Sheng Zeng, Yi-Xin Zeng, Miao Xu, Xiao Zhang
Summary: This review discusses the disease burden caused by EBV and the necessity of developing an EBV vaccine. Current efforts focus on improving the efficacy of vaccines through antigen selection, combination, and design. Various EBV glycoproteins show promising immunogenicity, and combinations of multiple EBV proteins become attractive approaches. Innovative vaccine design methods, such as virus-like particles and polymer-based nanoparticles, are also explored. Animal models and immune response activation strategies are important for vaccine development.
Review
Virology
Chu Xie, Lan-Yi Zhong, Guo-Long Bu, Ge-Xin Zhao, Bo-Yu Yuan, Yuan-Tao Liu, Cong Sun, Mu-Sheng Zeng
Summary: Epstein-Barr virus (EBV) infection is widespread and associated with various cancers and autoimmune diseases. During infection, EBV induces the production of different antibodies, which play significant roles in host response and disease pathogenesis. These antibodies have been extensively studied and found to be valuable for disease diagnosis, understanding disease mechanisms, and developing antiviral treatments. This review discusses the versatile roles of EBV antibodies as important biomarkers for EBV-related diseases, potential drivers of autoimmunity, and promising therapeutic agents for viral infection and pathogenesis.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Immunology
Jerry Zhang, Junji Xing
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Zheng-Zhou Lu, Cong Sun, Xiaolin Zhang, Yingying Peng, Yan Wang, Yan Zeng, Nannan Zhu, Yan Yuan, Mu-Sheng Zeng
Summary: Neuropilin 1 (NRP1) has been identified as an entry receptor for KSHV infection of mesenchymal stem cells (MSCs), facilitating the binding and internalization of KSHV. NRP1 interacts with KSHV glycoprotein B (gB) and TGF-beta receptor type 2 (TGFBR2), activating the TGFBR1/2 complex and promoting macropinocytosis-mediated KSHV internalization via small GTPases. These findings provide insights into the invasion strategy of KSHV in MSCs.
Article
Immunology
Elif Cakan, Marie Dominique Ah Kioon, Yolanda Garcia-Carmona, Salome Glauzy, David Oliver, Natsuko Yamakawa, Andrea Vega Loza, Yong Du, Jean-Nicolas Schickel, Joshua M. Boeckers, Chao Yang, Alessia Baldo, Lionel B. Ivashkiv, Ryan M. Young, Louis M. Staudt, Krishna L. Moody, Kerstin Nundel, Ann Marshak-Rothstein, Caspar I. van der Made, Alexander Hoischen, Anthony Hayward, Marzia Rossato, Timothy R. D. J. Radstake, Charlotte Cunningham-Rundles, Changwan Ryu, Erica L. Herzog, Franck J. Barrat, Eric Meffre
Summary: TLR9 and CXCL4 play important roles in central B cell tolerance, with TLR9 regulating the removal of autoreactive clones and CXCL4 inhibiting TLR9 function by sequestering its ligands. The findings suggest that correcting defective TLR9 function may be a potential therapeutic strategy for restoring B cell tolerance in SSc patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li
Summary: In this study, the crystal structure of TRIM56, a member of the RING E3 ligase, was solved. It was found that TRIM56 forms a tetramer consisting of two anti-parallel dimers. This tetramer structure allows for the existence of two RING domains on each side, forming an active homodimer that supports ubiquitin transfer. These findings suggest that the coiled-coil domain-mediated tetramer serves as a feasible scaffold for facilitating ubiquitin recruitment and transfer in E3 ligase activity.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li
Summary: Protein ubiquitination is crucial for controlling protein degradation and cell signaling pathways. This study elucidated the crystal structure of TRIM75, a member of the RING E3 ligase family, revealing its tetrameric structure and function.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Cell Biology
Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing, Zhiqiang Zhang
Summary: Our study shows that TRIM18 negatively regulates viral myocarditis, lung inflammation, and brain damage by downregulating innate immune activation induced by both RNA and DNA viruses. We demonstrate that TRIM18 recruits PPM1A to inactivate TBK1, which blocks the interaction between TBK1 and its upstream adaptors during viral infections. Additionally, TRIM18 stabilizes PPM1A through K63-linked ubiquitination.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
