Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Virology
Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G. Kosowicz, Jun O. Liu, Richard F. Ambinder
Summary: Research found that As2O3 can increase EBV Zta gene expression while blocking late lytic gene expression and virion production. Additionally, the effects of As2O3 on EBV gene expression may be mediated by pathways other than the ISR signaling pathway.
Article
Multidisciplinary Sciences
Xueyi Zheng, Ruixuan Wang, Xinke Zhang, Yan Sun, Haohuan Zhang, Zihan Zhao, Yuanhang Zheng, Jing Luo, Jiangyu Zhang, Hongmei Wu, Dan Huang, Wenbiao Zhu, Jianning Chen, Qinghua Cao, Hong Zeng, Rongzhen Luo, Peng Li, Lilong Lan, Jingping Yun, Dan Xie, Wei-Shi Zheng, Junhang Luo, Muyan Cai
Summary: This study introduces a deep convolutional neural network called EBVNet and its fusion with pathologists for predicting Epstein-Barr virus-associated gastric cancer (EBVaGC) from histopathology. EBVNet shows high accuracy in discriminating EBVaGC and the human-machine fusion significantly improves diagnostic performance.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Qi Zheng, Kun Zhu, Cai-Na Gao, Yi-Ping Xu, Mei-Ping Lu
Summary: This study found that JDM patients had a higher rate of EBV infection in the early stage, and specific lymphocyte subsets showed changes after treatment. The level of CD3(-)CD16(+)CD56(+) cells may be associated with the clinical course of JDM.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Xubing Long, Jing Yang, Xiaolin Zhang, Ziwei Yang, Yang Li, Fan Wang, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that Epstein-Barr virus lytic replication inhibits inflammasome activation through the immediate-early protein BRLF1, leading to altered immune responses in T cells and NK cells.
Article
Microbiology
Quincy Rosemarie, Elijah Kirschstein, Bill Sugden
Summary: We have discovered how Epstein-Barr virus (EBV) induces the reorganization of cellular chromatin, with viral DNA replication occurring in the chromatin-free regions. Five families of DNA viruses induce similar reorganization, and they infect a variety of hosts. The viral genes and processes required for EBV's chromatin reorganization have been identified, and a two-step model for the process has been proposed. The importance of chromatin reorganization in viral life cycles is emphasized. Overall, a 9 out of 10 score is given for the importance of this research.
Article
Virology
Devin N. Fachko, Yan Chen, Rebecca L. Skalsky
Summary: It has been found that EBV miR-BHRF1-3 can suppress lytic replication by directly inhibiting Zta expression. Moreover, nucleotide variants that impact the function of miR-BHRF1-3 have been identified, which may contribute to specific EBV pathologies.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera
Summary: This study demonstrated that Decitabine treatment can reduce the 5mC levels in the EBV genome and increase the amount of open chromatin in gastric cancer cell lines. It also revealed the presence of heterogeneous epigenetic states within the EBV genome, which are disrupted by Decitabine. These findings emphasize the importance of 5mC in maintaining EBV genomic chromatin structure and latency.
Article
Microbiology
Rachel Hood Edwards, Nancy Raab-Traub
Summary: This study evaluated the impact of EBV and BART lncRNAs on cellular expression, showing that they induce changes in cellular miRs and lncRNAs. In vivo expression changes reflect increased cellular miRs in all tumors, while the BART lncRNA may inhibit the function of induced cellular miRs. The study provides insights into the total effects of EBV and BART lncRNA on cellular RNA expression.
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Review
Virology
Chung-Pei Lee, Mei-Ru Chen
Summary: The nuclear envelope of eukaryotic cells plays a crucial role in maintaining the structural integrity of the nucleus and supporting various cellular processes. Viral proteins from Epstein-Barr virus, such as BGLF4 kinase and the nuclear egress complex BFRF1/BFRF2, have been found to regulate and modulate the nuclear envelope structure in different ways. This review highlights the impact of viral lytic gene expression on nuclear envelope structure and its related cellular processes.
Article
Biochemistry & Molecular Biology
Lee-Wen Chen, Shie-Shan Wang, Chien-Hui Hung, Ya-Hui Hung, Chun-Liang Lin, Pey-Jium Chang
Summary: The unfolded protein response (UPR) is crucial for alleviating endoplasmic reticulum (ER) stress and many viruses manipulate the UPR signaling network. In the lytic cycle of Epstein-Barr virus (EBV), the expression of central UPR regulator GRP78 is up-regulated, and knockdown of GRP78 reduces virus particle production. BMLF1 is identified as a key regulator contributing to the activation of the grp78 gene promoter and can trigger the activation of the UPR senor ATF6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Mike Dorothea, Jia Xie, Stephanie Pei Tung Yiu, Alan Kwok Shing Chiang
Summary: This review summarizes the oncogenic roles of Epstein-Barr virus (EBV) lytic proteins, which are expressed during the latent and lytic replication cycles of the virus, and categorizes them based on the cancer hallmarks displayed. The oncogenic properties of several EBV lytic proteins are postulated by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses.
Article
Biochemistry & Molecular Biology
Belle A. Henry, Virginie Marchand, Brent T. Schlegel, Mark Helm, Yuri Motorin, Nara Lee
Summary: In this study, we discovered that the noncoding RNA EBER2 from EBV is pseudouridylated, and this modification is crucial for RNA stability and efficient viral lytic replication.
Article
Biochemistry & Molecular Biology
Praphatson Malat, Tipaya Ekalaksananan, Chukkris Heawchaiyaphum, Supawadee Suebsasana, Sittiruk Roytrakul, Yodying Yingchutrakul, Chamsai Pientong
Summary: Andrographolide inhibits the reactivation of Epstein-Barr virus in EBV-positive cancer cells by inhibiting EBV lytic genes, possibly through histone modifications.
Article
Virology
Christine A. King, Xiaofan Li, Arturo Barbachano-Guerrero, Sumita Bhaduri-McIntosh
JOURNAL OF VIROLOGY
(2015)
Review
Microbiology
Xiaofan Li, Sumita Bhaduri-McIntosh
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Microbiology
Xiaofan Li, Eric M. Burton, Sumita Bhaduri-McIntosh
Article
Virology
Xiaofan Li, Eric M. Burton, Siva Koganti, Jizu Zhi, Francis Doyle, Scott A. Tenenbaum, Biljana Horn, Sumita Bhaduri-McIntosh
JOURNAL OF VIROLOGY
(2018)
Article
Oncology
Xing Wang, Zhiheng He, Tian Xia, Xiaofan Li, Deguang Liang, Xianzhi Lin, Hao Wen, Ke Lan
Article
Virology
Xiaofan Li, Deguang Liang, Xianzhi Lin, Erle S. Robertson, Ke Lan
JOURNAL OF VIROLOGY
(2011)
Article
Virology
Xianzhi Lin, Xiaofan Li, Deguang Liang, Ke Lan
JOURNAL OF VIROLOGY
(2012)
Article
Biochemistry & Molecular Biology
Vladimir Majerciak, Mathew Lu, Xiaofan Li, Zhi-Ming Zheng
Article
Virology
Xiaofan Li, Sergei Kozlov, Ayman EI-Guindy, Sumita Bhaduri-McIntosh
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Tiffany R. Frey, Jozan Brathwaite, Xiaofan Li, Sandeepta Burgula, Ibukun A. Akinyemi, Saurabh Agarwal, Eric M. Burton, Mats Ljungman, Michael T. McIntosh, Sumita Bhaduri-McIntosh
JOURNAL OF VIROLOGY
(2020)
Article
Multidisciplinary Sciences
Susan M. Watanabe, Lorna S. Ehrlich, Madeleine Strickland, Xiaofan Li, Veronica Soloveva, Arthur J. Goff, Charles B. Stauft, Sumita Bhaduri-McIntosh, Nico Tjandra, Carol Carter
SCIENTIFIC REPORTS
(2020)
Article
Virology
Xiaofan Li, Ibukun A. Akinyemi, Jeehyun Karen You, Mohammad Ali Rezaei, Chenglong Li, Michael T. McIntosh, Maurizio Del Poeta, Sumita Bhaduri-McIntosha
JOURNAL OF VIROLOGY
(2020)
Article
Microbiology
Michael T. McIntosh, Siva Koganti, J. Lucas Boatwright, Xiaofan Li, Salvatore V. Spadaro, Alexis C. Brantly, Jasmine B. Ayers, Ramon D. Perez, Eric M. Burton, Sandeepta Burgula, Thomas MacCarthy, Sumita Bhaduri-McIntosh
Article
Microbiology
Eric M. Burton, Ibukun A. Akinyemi, Tiffany R. Frey, Huanzhou Xu, Xiaofan Li, Lai Jing Su, Jizu Zhi, Michael T. McIntosh, Sumita Bhaduri-McIntosh
Summary: SZF1, a KRAB-ZFP, can silence different target sites in both the host and EBV genomes, facilitating the establishment of viral latency without inducing the lytic phase. This differential approach reflects a strategy for the host to regulate persistent invaders while maintaining its own homeostasis.