Article
Medicine, Research & Experimental
Federico Costanzo, Marta Martinez Diez, Gema Santamaria Nunez, Juan Ignacio Diaz-Hernandez, Carlos Mario Genes Robles, Javier Diez Perez, Emmanuel Compe, Romeo Ricci, Tsai-Kun Li, Frederic Coin, Juan Fernando Martinez Leal, Eva Maria Garrido-Martin, Jean Marc Egly
Summary: This article focuses on the neuroendocrine subtypes of small-cell lung cancer (SCLC), SCLC-A and SCLC-N, and highlights the transcription addiction driven by ASCL1 and NEUROD1 transcription factors. The study reveals that lurbinectedin, a marine agent, effectively targets the CpG islands downstream of the transcription start site, inhibiting gene expression and suppressing the tumorigenic properties and neuroendocrine features of SCLC.
EMBO MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Laura Thomas, Basma Taleb Ismail, Peter Askjaer, Geraldine Seydoux
Summary: Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier between nucleoplasm and cytoplasm. In an intact C. elegans, cytoplasmic Nup foci are condensates of highly cohesive FG repeat-containing nucleoporins (FG-Nups), which are maintained near their solubility limit in the cytoplasm by posttranslational modifications and chaperone activity. Nup foci only appear in developing sperm, oocytes, and embryos, dissolve during M phase, and are dispensable for nuclear pore assembly.
Editorial Material
Biodiversity Conservation
Sharon A. Robinson
Summary: Climate change poses a threat to polar landscapes and their unique biodiversity. Wild reindeer are cultural and ecological keystone species, active in the northern Eurasian Arctic; Antarctic terrestrial biodiversity is found on ice-covered islands. This article discusses how climate change threatens these marine and terrestrial habitats and the biodiversity they support.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Chirag Nepal, Jesper B. Andersen
Summary: The study investigates the regulatory mechanisms of alternative promoters in hepatocellular carcinoma and provides insights into their sequence and epigenetics landscape. The authors identify 4083 alternative promoters in 2926 multi-promoter genes, which are rarely detected in normal livers. These alternative promoters play a role in oncogenic processes and are associated with overall survival. The findings reveal the unique characteristics of alternative promoters, such as their narrow nucleosome depleted regions and enrichment of tissue-specific transcription factors.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Pratik Goswami, Martin Bartas, Matej Lexa, Natalia Bohalova, Adriana Volna, Jiri Cerven, Veronika Cervenova, Petr Pecinka, Vladimir Spunda, Miroslav Fojta, Vaclav Brazda
Summary: By analyzing high-frequency mutations of SARS-CoV-2 and their overlay with IR and CpG island loci, this study found that hot-spot mutations of the virus are significantly enriched within these regions. The hypothesis is that hypermethylation of CpG islands may decrease the transcription of viral ORFs and therefore limit the progression of the disease.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Cell Biology
Katherine A. Maniates, Andrew Singson
Summary: Complementary forward and reverse genetic approaches have led to a recent surge in the discovery of fertilization genes in various model systems. The number of genetically validated gamete surface molecules has more than doubled in the past few years, with all sperm fertilization genes encoding transmembrane or secreted molecules. However, the discovery of genes encoding oocyte molecules has lagged behind. This review discusses potential experimental biases and biological reasons that may have hindered the identification of egg fertilization genes, as well as current strategies to overcome these obstacles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kiyomi Raye Kaneshiro, Thea A. Egelhofer, Andreas Rechtsteiner, Chad Cockrum, Susan Strome
Summary: The transmission of chromatin states from parent cells to daughter cells is important for preserving cell identity. A study on Caenorhabditis elegans showed that alleles inherited without a specific chromatin mark were more likely to be up-regulated in offspring cells, and the tissue context played a role in determining which genes were up-regulated. This study also demonstrated the transgenerational epigenetic transmission of chromatin states in C. elegans.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Yu Wang, Meghan Lee Arnold, Anna Joelle Smart, Guoqiang Wang, Rebecca J. Androwski, Andres Morera, Ken C. Q. Nguyen, Peter J. Schweinsberg, Ge Bai, Jason Cooper, David H. Hall, Monica Driscoll, Barth D. Grant, Paschalis Kratsios
Summary: Research reveals that exophers produced by mechanosensory neurons in C. elegans are engulfed by surrounding hypodermal skin cells and broken up into smaller vesicles, which are gradually degraded by hypodermal lysosomes. This process relies on factors and pathways in the hypodermis, including actin and molecules related to lysosome activity. Furthermore, specific interaction between the neuron and phagocyte is crucial for an efficient exopher response.
Article
Cell Biology
Shijiao Huang, Marshall B. Howington, Craig J. Dobry, Charles R. Evans, Scott F. Leiser
Summary: The FMO family plays an important endogenous role in regulating cellular stress resistance and major cellular metabolic activities, including central carbon metabolism. Studies show that FMO expression enhances mitochondrial respiration, changes central carbon metabolism, and improves survival under stress through enhanced c-Jun N-terminal kinase activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Thanh Thi Vuong-Brender, Sean Flynn, Yvonne Vallis, Mario de Bono
Summary: CAMTAs are ancient proteins expressed broadly in nervous systems, controlling neuronal CaM levels. Loss of CAMT-1, the sole C. elegans CAMTA, results in behavioral and neuronal Ca2+ signaling defects.
Article
Mathematics, Applied
Zouheir Amara, Mourad Oudghiri
Summary: The paper demonstrates that on a separable complex Hilbert space, every bounded linear operator can be perturbed by a finite-rank operator in such a way that it is not C-normal with respect to any conjugation C.
ANNALS OF FUNCTIONAL ANALYSIS
(2021)
Article
Geosciences, Multidisciplinary
Jieming Chou, Weixing Zhao, Jiangnan Li, Yuan Xu, Fan Yang, Mingyang Sun, Yuanmeng Li
Summary: Scientific predictions of critical global temperature increases and assessments of associated changes in extreme climate events using CMIP6 model outputs show that global mean temperatures are projected to rise by 1.5 degrees C/2.0 degrees C by approximately 2030/2049 under certain scenarios. Specific climate events such as warm days, rice heat damage, and extreme precipitation are expected to increase significantly under 2.0 degrees C of global warming.
FRONTIERS IN EARTH SCIENCE
(2021)
Article
Neurosciences
Bin Yu, Ya Wang, Shangbang Gao
Summary: Motor rhythm is generated and sustained by oscillatory neuronal activity, with A-class excitatory motor neurons functioning as intrinsic oscillators. Different types of rPSC patterns have been identified, each with distinct kinetics and channel-dependence.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Green & Sustainable Science & Technology
Naveenarani Murugan, Ravinder Kumar, Shashi Kant Pandey, Pooja Dhansu, Mahadevaiah Chennappa, Saranya Nallusamy, Hemaprabha Govindakurup, Appunu Chinnaswamy
Summary: This study investigated the characteristics and regulatory mechanisms of phosphate transporter gene promoters through computer analysis. It found that one of the gene promoters can enhance gene expression under salt stress conditions, which is of great significance for the development of salt-tolerant transgenic crops.
Article
Biochemistry & Molecular Biology
Bingbing Song, Wen Xia, Tong Li, Rui Hai Liu
Summary: The combination of blueberry extracts and apple peel extracts can improve oxidative stress and extend the lifespan of nematodes by regulating mitochondrial function. This study provides a theoretical basis for exploring the role of mitochondrial function in regulating oxidative stress and aging process.
Article
Cell Biology
Jennifer K. Heppert, Daniel J. Dickinson, Ariel M. Pani, Christopher D. Higgins, Annette Steward, Julie Ahringer, Jeffrey R. Kuhn, Bob Goldstein
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Multidisciplinary Sciences
Kenneth J. Evans, Ni Huang, Przemyslaw Stempor, Michael A. Chesney, Thomas A. Down, Julie Ahringer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Microbiology
Melanie Tanguy, Louise Veron, Przemyslaw Stempor, Julie Ahringer, Peter Sarkies, Eric A. Miska
Article
Biology
Alicia N. McMurchy, Przemyslaw Stempor, Tessa Gaarenstroom, Brian Wysolmerski, Yan Dong, Darya Aussianikava, Alex Appert, Ni Huang, Paulina Kolasinska-Zwierz, Alexandra Sapetschnig, Eric A. Miska, Julie Ahringer
Article
Genetics & Heredity
Julie Ahringer, Susan M. Gasser
Article
Genetics & Heredity
Julie Ahringer, Susan M. Gasser
Article
Biology
Sundar Ram Naganathan, Sebastian Fuerthauer, Josana Rodriguez, Bruno Thomas Fievet, Frank Juelicher, Julie Ahringer, Carlo Vittorio Cannistraci, Stephan W. Grill
Article
Genetics & Heredity
Ting Deng, Przemyslaw Stempor, Alex Appert, Michael Daube, Julie Ahringer, Alex Hajnal, Evelyn Lattmann
Article
Biochemistry & Molecular Biology
Jacques Serizay, Yan Dong, Jurgen Janes, Michael Chesney, Chiara Cerrato, Julie Ahringer
Article
Biochemistry & Molecular Biology
Ni Huang, Wei Qiang Seow, Alex Appert, Yan Dong, Przemyslaw Stempor, Julie Ahringer
Summary: Nuclear organization and chromatin interactions are crucial for genome function, but accurately determining chromatin connections at a high resolution remains challenging. This study introduces a new tool called ARC-C, which allows for the analysis of interactions between regulatory elements throughout the entire genome, while also providing insights into the structure and domain-level architecture of chromatin.
Article
Multidisciplinary Sciences
Francesco Nicola Carelli, Chiara Cerrato, Yan Dong, Alex Appert, Abby Dernburg, Julie Ahringer
Summary: The movement of selfish DNA elements can lead to widespread genomic alterations and rewiring of germline transcriptional regulation. This study found that transposon expansions in Caenorhabditis nematodes led to the acquisition of germline-specific promoters from miniature inverted repeat transposable elements (TEs). These promoters are regulated by a transcription factor related to a transposase. Comparative analyses revealed evolutionary conservation and species-specificity of the co-opted promoters.
Article
Biochemistry & Molecular Biology
Francesco N. Carelli, Garima Sharma, Julie Ahringer
Article
Cell Biology
Josana Rodriguez, Florent Peglion, Jack Martin, Lars Hubatsch, Jacob Reich, Nisha Hirani, Alicia G. Gubieda, Jon Roffey, Artur Ribeiro Fernandes, Daniel St Johnston, Julie Ahringer, Nathan W. Goehring
DEVELOPMENTAL CELL
(2017)