期刊
GENOME BIOLOGY AND EVOLUTION
卷 6, 期 9, 页码 2368-2379出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evu192
关键词
positive selection; PAML; Colletotrichum graminicola; pathogenicity; arms race hypothesis
资金
- Ministerio de Ciencia e Innovacion of Spain [AGL2011-29446]
- Ministerio de Economia y Competitividad [AGL2012-34139]
- Junta de Castilla y Leon [SA-165U13]
- Formacion de Personal Investigador graduate fellowship [BES-2009-013920]
- Formacion del Profesorado Universitario graduated fellowship [AP2009-2656]
- Swiss Federal Institute of Technology (ETH Zurich)
- Swiss National Science Foundation [31003A-127325]
- Swiss National Science Foundation (SNF) [31003A_127325] Funding Source: Swiss National Science Foundation (SNF)
Natural selection leaves imprints on DNA, offering the opportunity to identify functionally important regions of the genome. Identifying the genomic regions affected by natural selection within pathogens can aid in the pursuit of effective strategies to control diseases. In this study, we analyzed genome-wide patterns of selection acting on different classes of sequences in a worldwide sample of eight strains of the model plant-pathogenic fungus Colletotrichum graminicola. We found evidence of selective sweeps, balancing selection, and positive selection affecting both protein-coding and noncoding DNA of pathogenicity-related sequences. Genes encoding putative effector proteins and secondary metabolite biosynthetic enzymes show evidence of positive selection acting on the coding sequence, consistent with an Arms Race model of evolution. The 5' untranslated regions (UTRs) of genes coding for effector proteins and genes upregulated during infection show an excess of high-frequency polymorphisms likely the consequence of balancing selection and consistent with the Red Queen hypothesis of evolution acting on these putative regulatory sequences. Based on the findings of this work, we propose that even though adaptive substitutions on coding sequences are important for proteins that interact directly with the host, polymorphisms in the regulatory sequences may confer flexibility of gene expression in the virulence processes of this important plant pathogen.
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