Article
Reproductive Biology
Xiangyan Dai, Xinkai Cheng, Jianfei Huang, Yanping Gao, Deshou Wang, Zhi Feng, Gang Zhai, Qiyong Lou, Jiangyan He, Zhijian Wang, Zhan Yin
Summary: Our study demonstrates the crucial role of Rbm46 in zebrafish reproduction, showing that disruption of Rbm46 leads to masculinization and infertility by impairing germ cell progression through meiosis prophase I. Rbm46 may be involved in posttranscriptional regulation of key genes essential for germ cell development during gametogenesis.
BIOLOGY OF REPRODUCTION
(2021)
Review
Environmental Sciences
Muhammad Tanveer, Nimra Mansha, Afzal Nimra, Muhammad Babar Khawar, Ali Afzal, Hanan Afzal, Muhammad Farooq, Sadia Ehsan, Rabbia Rana, Sara Shahzaman
Summary: Microplastics (MPs) are biologically active environmental pollutants that significantly impact the ecosystem and human health. These particles increase oxidative stress, leading to tissue damage, developmental abnormalities, metabolic disorders, epigenetic changes, abnormal reproduction, and reduced gamete quality. While there have been numerous studies on the effects of MPs on aquatic organisms, particularly their reproduction, the specific impact on mammalian reproduction, especially humans, remains limited. This review examines the effects of MPs on male and female reproduction, focusing on compromised gamete quality, gamete toxicity, apoptosis, and DNA damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yinghong Chen, Chao Liu, Yongliang Shang, Liying Wang, Wei Li, Guoping Li
Summary: By using the CRISPR/Cas9 system, researchers successfully generated an Adam21 knockout mouse model and found that male mice lacking Adam21 exhibit normal fertility and do not show any obvious defects in spermatogenesis or sperm motility.
Article
Toxicology
Ji-Guang Gao, Yu Jiang, Jiu-Tao Zheng, Liu-Wang Nie
Summary: Teenagers who consume junk foods high in acrylamide (AA) may experience decreased reproductive capacity. This study investigated the effects of pubertal AA exposure on spermatogenesis in male mice. The results showed that AA exposure during puberty led to increased germ cell apoptosis, decreased sperm concentration, and defects in sperm. AA exposure also disrupted the meiotic process, affecting the progression of meiotic prophase I.
TOXICOLOGY LETTERS
(2022)
Article
Environmental Sciences
Yu Wei, Wenfeng Geng, Taifa Zhang, Huan He, Jinxia Zhai
Summary: This study aimed to evaluate the protective effects of N-acetylcysteine (NAC) on meiotic arrest in spermatocytes and decreased sperm quality in BDE-209-exposed mice. The results showed that pretreatment with NAC attenuated the oxidative stress status induced by BDE-209, improved testicular histology and sperm quality, and enhanced DNA damage repair. Therefore, NAC may have a protective effect against the spermatogenesis dysfunction caused by BDE-209.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jinxia Zhai, Wenfeng Geng, Taifa Zhang, Yu Wei, Huan He, Wenjing Chen
Summary: This study found that BDE-209 has detrimental impacts on meiotic prophase I of spermatocytes in mice, including decreased sperm quality, increased oxidative stress and DNA damage, as well as impaired homologous recombination.
Article
Cell Biology
Xue Zhang, Yong Zuo, Jianhua Zhang, Di Zhang, Muhammad Naeem, Yanzhong Chang, Zhenhua Shi
Summary: Sevoflurane, a commonly used inhalation anesthetic, has a detrimental effect on spermatogenesis and fertilization in male animals. This study explores the mechanism behind this impact, suggesting that Sev disrupts iron metabolism in the testis and epididymis, leading to inhibited sperm production. The damaging effects of Sev on fertility can be ameliorated through iron supplementation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yong Zou, Liyu Zhang, Min Yue, Zhen Zou, Xu Wu, Qiuyan Zhang, Yue Huang, Shaohua Zeng, Chengzhi Chen, Jieying Gao
Summary: This study found that exposure to high doses of Thiacloprid (THIA) in mice can have detrimental effects on reproductive function, while low doses have no significant impact.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
German Gonzalez-Almagro, Juan Luis Suarez, Julian Luengo, Jose-Ramon Cano, Salvador Garcia
Summary: This paper proposes a method of incorporating constraints into the clustering process, including quantifying constraint relevance, learning a metric matrix, computing instance similarities, and performing clustering merges. Experimental results demonstrate a significant improvement of this method in the constrained clustering problem.
Article
Environmental Sciences
Yunhai Zhang, Lei Sun, Dandan Zhang, Yang Gao, Huijie Ma, Yanfeng Xue, Mianqun Zhang
Summary: Butylparaben, a common environmental endocrine disruptor used in cosmetics and personal care products, has been shown to adversely affect female fertility. This study found that exposure to butylparaben impairs oocyte meiotic capacity and fertilization potential, leading to mitochondrial dysfunction and oxidative stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Yanling Wan, Tahir Muhammad, Tao Huang, Yue Lv, Qianqian Sha, Shuang Yang, Gang Lu, Wai-yee Chan, Jinlong Ma, Hongbin Liu
Summary: This study found that maternal obesity has negative effects on meiotic structure and development of oocytes, which can be improved by adding IGF2. Supplementation of IGF2 improves blastocyst formation, reduces reactive oxygen species levels, and improves mitochondrial function. Additionally, IGF2 increases protein synthesis and decreases apoptosis. These findings contribute to improving culturing conditions in assisted reproduction technologies to overcome the negative impact of obesity on reproductive outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guilherme Caeiro-Dias, Alan Brelsford, Mariana Meneses-Ribeiro, Pierre-Andre Crochet, Catarina Pinho
Summary: This study analyzed a natural hybrid zone between two species in a late stage of speciation using ddRADseq genotyping. The results showed strong but incomplete reproductive isolation within the hybrid zone. Some loci showed signs of potential positive selection, and the Z chromosome was suggested to play an important role in reproductive isolation.
Article
Plant Sciences
Hai-Ping Zhang, Zhi-Bin Tao, Judith Trunschke, Mani Shrestha, Daniela Scaccabarozzi, Hong Wang, Zong-Xin Ren
Summary: Comparison and quantification of multiple pre- and post-pollination barriers are crucial for understanding factors promoting reproductive isolation. This study focused on three sympatric Habenaria species, and revealed the importance of pollinators as isolating barriers.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Behavioral Sciences
Laura L. Hurley, Riccardo Ton, Melissah Rowe, Katherine L. Buchanan, Simon C. Griffith, Ondi L. Crino
Summary: Birds that breed opportunistically maintain partial activation of reproductive systems to rapidly exploit environmental conditions when they become suitable for breeding. Males of seasonally breeding birds downregulate testosterone production outside of a breeding context to minimize costs.
HORMONES AND BEHAVIOR
(2023)
Article
Nutrition & Dietetics
Jihua Xu, Xiang Zhang, Xiaohong Sun, Qiang Lv, Yugang Zhang
Summary: The research showed that 1 mg/kg of RAAE had significant effects in rescuing spermatogenesis in busulfan-treated mice, improving sperm quantity and vitality, and regulating specific metabolites to restore male reproductive system function.
FRONTIERS IN NUTRITION
(2021)
Meeting Abstract
Hematology
Ayana Kon, Satoshi Yamazaki, Keisuke Kataoka, Tetsuichi Yoshizato, Yusuke Shiozawa, Masashi Sanada, Kenichi Yoshida, Yasunobu Nagata, Yuichi Shiraishi, Satoru Miyano, Torsten Haferlach, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa
EXPERIMENTAL HEMATOLOGY
(2015)
Article
Immunology
Takeshi Inoue, Masahiro Morita, Atsushi Hijikata, Yoko Fukuda-Yuzawa, Shungo Adachi, Kyoichi Isono, Tomokatsu Ikawa, Hiroshi Kawamoto, Haruhiko Koseki, Tohru Natsume, Taro Fukao, Osamu Ohara, Tadashi Yamamoto, Tomohiro Kurosaki
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Article
Genetics & Heredity
Stefan Schoenfelder, Robert Sugar, Andrew Dimond, Biola-Maria Javierre, Harry Armstrong, Borbala Mifsud, Emilia Dimitrova, Louise Matheson, Filipe Tavares-Cadete, Mayra Furlan-Magaril, Anne Segonds-Pichon, Wiktor Jurkowski, Steven W. Wingett, Kristina Tabbada, Simon Andrews, Bram Herman, Emily LeProust, Cameron S. Osborne, Haruhiko Koseki, Peter Fraser, Nicholas M. Luscombe, Sarah Elderkin
Article
Multidisciplinary Sciences
Erik Arner, Carsten O. Daub, Kristoffer Vitting-Seerup, Robin Andersson, Berit Lilje, Finn Drablos, Andreas Lennartsson, Michelle Roennerblad, Olga Hrydziuszko, Morana Vitezic, Tom C. Freeman, Ahmad M. N. Alhendi, Peter Arner, Richard Axton, J. Kenneth Baillie, Anthony Beckhouse, Beatrice Bodega, James Briggs, Frank Brombacher, Margaret Davis, Michael Detmar, Anna Ehrlund, Mitsuhiro Endoh, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Geoffrey J. Faulkner, Carmelo Ferrai, Malcolm E. Fisher, Lesley Forrester, Daniel Goldowitz, Reto Guler, Thomas Ha, Mitsuko Hara, Meenhard Herlyn, Tomokatsu Ikawa, Chieko Kai, Hiroshi Kawamoto, Levon M. Khachigian, S. Peter Klinken, Soichi Kojima, Haruhiko Koseki, Sarah Klein, Niklas Mejhert, Ken Miyaguchi, Yosuke Mizuno, Mitsuru Morimoto, Kelly J. Morris, Christine Mummery, Yutaka Nakachi, Soichi Ogishima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry Ovchinnikov, Robert Passier, Margaret Patrikakis, Ana Pombo, Xian-Yang Qin, Sugata Roy, Hiroki Sato, Suzana Savvi, Alka Saxena, Anita Schwegmann, Daisuke Sugiyama, Rolf Swoboda, Hiroshi Tanaka, Andru Tomoiu, Louise N. Winteringham, Ernst Wolvetang, Chiyo Yanagi-Mizuochi, Misako Yoneda, Susan Zabierowski, Peter Zhang, Imad Abugessaisa, Nicolas Bertin, Alexander D. Diehl, Shiro Fukuda, Masaaki Furuno, Jayson Harshbarger, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Yuri Ishizu, Masayoshi Itoh, Tsugumi Kawashima, Miki Kojima, Naoto Kondo, Marina Lizio, Terrence F. Meehan, Christopher J. Mungall, Mitsuyoshi Murata, Hiromi Nishiyori-Sueki, Serkan Sahin, Sayaka Nagao-Sato, Jessica Severin, Michiel J. L. de Hoon, Jun Kawai, Takeya Kasukawa, Timo Lassmann, Harukazu Suzuki, Hideya Kawaji, Kim M. Summers, Christine Wells, David A. Hume, Alistair R. R. Forrest, Albin Sandelin, Piero Carninci, Yoshihide Hayashizaki
Article
Multidisciplinary Sciences
Daisuke Kamimura, Kokichi Katsunuma, Yasunobu Arima, Toru Atsumi, Jing-jing Jiang, Hidenori Bando, Jie Meng, Lavannya Sabharwal, Andrea Stofkova, Naoki Nishikawa, Hironao Suzuki, Hideki Ogura, Naoko Ueda, Mineko Tsuruoka, Masaya Harada, Junya Kobayashi, Takanori Hasegawa, Hisahiro Yoshida, Haruhiko Koseki, Ikuo Miura, Shigeharu Wakana, Keigo Nishida, Hidemitsu Kitamura, Toshiyuki Fukada, Toshio Hirano, Masaaki Murakami
NATURE COMMUNICATIONS
(2015)
Article
Biology
Mitsuhiro Endoh, Takaho A. Endo, Jun Shinga, Katsuhiko Hayashi, Anca Farcas, Kit-Wan Ma, Shinsuke Ito, Jafar Sharif, Tamie Endoh, Naoko Onaga, Manabu Nakayama, Tomoyuki Ishikura, Osamu Masui, Benedikt M. Kessler, Toshio Suda, Osamu Ohara, Akihiko Okuda, Robert Klose, Haruhiko Koseki
Article
Biology
Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M. Kessler, Haruhiko Koseki, Robert J. Klose
Article
Biochemistry & Molecular Biology
Anne H. Turberfield, Takashi Kondo, Manabu Nakayama, Yoko Koseki, Hamish W. King, Haruhiko Koseki, Robert J. Klose
NUCLEIC ACIDS RESEARCH
(2019)
Article
Immunology
Masahiro Kiuchi, Atsushi Onodera, Kota Kokubo, Tomomi Ichikawa, Yuki Morimoto, Eiryo Kawakami, Naoya Takayama, Koji Eto, Haruhiko Koseki, Kiyoshi Hirahara, Toshinori Nakayama
Summary: Research has shown that Cxxc1 plays a crucial role in regulating the transcription of a specific set of genes in CD4(+) T cells through epigenetic control, affecting the differentiation process of cells and thereby influencing the establishment of the T cell immune system.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ni Zeng, Christophe M. Capelle, Alexandre Baron, Takumi Kobayashi, Severine Cire, Vera Tslaf, Cathy Leonard, Djalil Coowar, Haruhiko Koseki, Astrid M. Westendorf, Jan Buer, Dirk Brenner, Rejko Krueger, Rudi Balling, Markus Ollert, Feng Q. Hefeng
Summary: Loss of DJ-1 gene reduces signs of immune aging, providing a potential target for intervention in immune aging and aging-related diseases.
Article
Multidisciplinary Sciences
Kentaro Mochizuki, Jafar Sharif, Kenjiro Shirane, Kousuke Uranishi, Aaron B. Bogutz, Sanne M. Janssen, Ayumu Suzuki, Akihiko Okuda, Haruhiko Koseki, Matthew C. Lorincz
Summary: Germline genes are repressed by a combination of DNA methylation and histone marks, with PRC1.6 playing a key role in the pre-implantation stage. In contrast, GGD genes are hypermethylated in EpiLCs and their silencing is dependent upon SETDB1, PRC1.6/RING1B, and DNA methylation.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Nina Tanaskovic, Mattia Dalsass, Marco Filipuzzi, Giorgia Ceccotti, Alessandro Verrecchia, Paola Nicoli, Mirko Doni, Daniela Olivero, Diego Pasini, Haruhiko Koseki, Arianna Sabo, Andrea Bisso, Bruno Amati
Summary: Loss of Mga and PRC1.6 has no significant impact on Myc-induced lymphomagenesis in transgenic mice, but loss of Pcgf6 accelerates tumor formation. This suggests an unexpected tumor suppressor activity of Pcgf6 independent of Mga and PRC1.6.
LIFE SCIENCE ALLIANCE
(2022)
Article
Multidisciplinary Sciences
Mengwen Hu, Yu-Han Yeh, Yasuhisa Munakata, Hironori Abe, Akihiko Sakashita, So Maezawa, Miguel Vidal, Haruhiko Koseki, Neil Hunter, Richard M. Schultz, Satoshi H. Namekawa
Summary: The Polycomb Repressive Complex 1 (PRC1) is crucial for the formation and maintenance of the ovarian reserve, which is essential for the female reproductive lifespan. Through establishing repressive chromatin states, PRC1 suppresses the gene expression program of meiotic prophase-I, enabling the transition to dictyate arrest and preventing the depletion of the ovarian reserve.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Shuhei Uemura, Shoji Maenohara, Kimiko Inoue, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Mayuko Kurumizaka, Kazuo Yamagata, Jafar Sharif, Haruhiko Koseki, Koji Ueda, Motoko Unoki, Hiroyuki Sasaki
Summary: In this study, the researchers found that the specific knockout of the Uhrf1 gene in oocytes affects chromosome segregation, cleavage division, and preimplantation viability in mice. Further investigations showed that these phenotypes were associated with cytoplasmic defects and not nuclear defects. Proteomic analysis of the knockout oocytes revealed down-regulation of proteins related to microtubules and disorganization of the cytoplasmic architecture, including mislocalization of mitochondria, endoplasmic reticulum, and maternal complex components.
LIFE SCIENCE ALLIANCE
(2023)
Meeting Abstract
Hematology
A. Kon, S. Yamazaki, K. Kataoka, T. Yoshizato, Y. Shiozawa, M. Sanada, K. Yoshida, Y. Yamazaki, Y. Shiraishi, S. Miyano, M. Nakayama, H. Koseki, H. Nakauchi, S. Ogawa